Brian Fradet

@hormonemoon Remember…all studies are fake

HARVARD hizo un estudio para descubrir qué te hace vivir más tiempo. En el estudio siguieron a 724 hombres durante 80 años. Midieron todo, desde ingresos hasta coeficiente intelectual, e incluso genética. ¿El predictor número 1 de una muerte prematura? No tenía nada que ver con nada de eso... Aquí está lo que encontraron (hilo): El estudio comenzó en 1938 con dos grupos:

@nicknorwitz Grok is very skeptical of this study-ask to debunk

Ezetimibe cut my LDL by 56%. But that wasn't the point...

@REMASCULATE Vaccines

Madonna needs to hang it up

@Lpa_Doc All scientific studies are fake

As we are almost to the readout of the Lp(a)HORIZON trial in 2026, lets gauge the mood of the room with a poll: I think the Lp(a)HORIZON trial will show how much relative risk reduction (RRR) compared to placebo:

@CoachDanGo Do you include charcoal? Mini scoop

I max dosed psyllium husk but did not expect this. For the past 28 days, I've maxed out on psyllium husk, taking two tablespoons 3x a day, and it's quietly changed my life. Here's what it did to my body:

@Ryanmariebach78 Just to be clear 😀

What's a common phrase that annoys you? "To be clear"

@drterrysimpson And as always follow the money

And here we have the failed carb-hunger hypothesis, so lets dispense with their weird root cause. GLP-1 drugs don’t just blunt appetite. They change the physiology you’re claiming stays broken. Insulin secretion becomes appropriate instead of excessive. Glucagon gets suppressed. Hepatic glucose output drops. Fasting insulin falls. HbA1c improves. These changes show up early, before major weight loss. Hyperinsulinemia isn’t some mystical root cause floating untouched. It tracks with energy excess and insulin resistance. Reduce both and insulin levels come down. That’s exactly what happens. Calling it a “chemical crutch” is just moral posturing. We treat disordered physiology with medication all the time. No one accuses ACE inhibitors of creating “dependency” when blood pressure improves. If someone prefers diet and activity alone, fine. But dismissing GLP-1 therapy while it measurably improves insulin dynamics is not a sophisticated take. It’s just wrong. Oh, and lets look at the stats - what gets to the root cause of the issue vs what is the patch? Hmm, check the results

Questioning the marketing of a pharmaceutical product isn’t denial — it’s due diligence. The same rigor I’d apply to any investment claim, I apply to medical claims. Show me the absolute numbers, show me the NNT, show me the all-cause mortality data — and then we can have an adult conversation.”

cumulative exposure to LDL-C increases lifetime risk of mortality and adverse cardiac events, and is why statins are considered healthspan extending drugs.

@bryan_johnson Petite mort

Just had sex with Kate. Goodnight everyone.

@bobvarkey What’s that have to do with anything?

@Brianf53 There’s no patent for atorvastatin

I’m a Neurologist and I take a statin. That’s the difference between knowledge and action. Literally the first concept that we started learning in pathology in second MBBS from ‘Robbins’ was atherosclerosis. How fatty streaks develop: the earliest visible sign of atherosclerosis, develop in the aorta during early childhood, often by age 3, and are present in nearly all children by age 10. We then forgot all about it for many years . Most of our literature deals with secondary prevention, but I now realise after reading tons of literature on atherosclerosis and Braunwald’s LDL years concept, primary prevention of atherosclerotic cardiovascular disease is the way to go. What’s the point of knowing all this, If you don’t take steps to ‘heal thyself’ The lower you keep your cholesterol on the longer you can manage it, the less likely you are to suffer from the big three (CAD, stroke and Peripheral artery disease) There is some things you can modify and others you can’t. Your cholesterol levels are definitely a modifiable risk factor. If you don’t think so , check out the literature on "SMuRFs" (Standard Modifiable Cardiovascular Risk Factors).

@bobvarkey Fake science-Always ask: What’s the absolute benefit, who funded it, and was it blinded?

@NutritionMadeS3 Fake science-Always ask: What’s the absolute benefit, who funded it, and was it blinded?

I thought my LDL of 50 and ApoB of 55mg/dL were solid but a lot of these folks have me beat 🤣💪 Loving this new trend of #LowLDLPride

@MohammedAlo Fake science-Always ask: What’s the absolute benefit, who funded it, and was it blinded? Wouldn’t take if free or even paid

Two cheap supplements that cut your heart disease risk by over 50%. Cardiologist recommended! #top2 #heartdisease #cardiology #CardioTwitter #MedTwitter

@AndrewZywiecMD Fake science-Always ask: What’s the absolute benefit, who funded it, and was it blinded?

I hope the public was paying attention today, watching thousands of "doctors" post about how they take statins. No symptoms, no signs, no pathology, just because. A bunch of young, healthy, "educated" individuals with medical degrees, shamelessly promoting pharma. Whores. Doctor's are men who prescribe drugs, of which they know little, for illnesses, of which they know less, to humans, of whom they know nothing.

@SamaHoole Fake science-Always ask: What’s the absolute benefit, who funded it, and was it blinded?

Doctor: "The statin is non-negotiable given your family history." Patient: "My father had a heart attack at 58. He ate margarine his entire adult life on medical advice." Doctor: "Dietary fat isn't the issue." Patient: "The margarine?" Doctor: "We now know trans fats were problematic, yes." Patient: "You recommended them." Doctor: "The profession recommended them." Patient: "Based on the same lipid hypothesis you're using to prescribe me a statin." Doctor: "The science has moved on." Patient: "Which bit?" Doctor: "...LDL remains a key marker." Patient: "Right."

@MichaelAlbertMD Fake science-Always ask: What’s the absolute benefit, who funded it, and was it blinded?

I'm 36. I'm a physician. I take a statin—and ezetimibe—every day. No symptoms. No cardiac history. Just an honest read of the evidence. Here's what I found—and why I stopped waiting for a reason to act.

@traceyh415 Get it yes-if you’re stupid

Anyone get the shingles vaccine? I keep putting it off but I feel like it is time.

@MichaelAlbertMD Fake science-Always ask: What’s the absolute benefit, who funded it, and was it blinded?

The cholesterol wars are over. LDL won. New guidelines. Four landmark trials. An oral PCSK9 inhibitor that matches injectables. And data proving we should be treating patients we currently aren't. Here's everything clinicians need to know. 🧵

@AmmousMD Too numerous to speculate but huge.

How many heart attacks has Ancel Keys been responsible for?