David Lee

1/🧵Check out our new publication. “Multi-omic Rejuvenation and Lifespan Extension through Exposure to Youthful Circulation," which has been published in Nature Aging. nature.com/articles/s4358…

Multi-omic rejuvenation and life span extension on exposure to youthful circulation nature.com/articles/s4358…

A team of scientists has extended the lives of old mice by connecting their blood vessels to young mice. The study found infusions of youthful blood led the older animals to live 6-9% longer, roughly equivalent to six extra years for an average human. nyti.ms/3Qd6Suz

More here from David Lee. Data looks solid, look forward to more work including in other animal models ahead.🧑‍⚕️ twitter.com/DLee133/status…

@agingdoc1 @davidjglassMD @carlzimmer @nytimes @gladyshev_lab @wysscoray Yancova et al title: “….without positive effect for old”. Yacova et al data: old iso 1009.4days+/-14.6 vs old het 1063.0+/-34.4, p=0.056. Titles lie. Lifespan extension data from yancova et al is highly similar to ours (~6%).

@davidjglassMD @carlzimmer @nytimes @gladyshev_lab @wysscoray It's a great point David. I look forward to seeing the results from other strains and model organisms. Time will tell how generalizable (or sensitive to subtle protocol deviations) this may be.

Blood of Young Mice Extends Life in the Old "Infusions of youthful blood led older mice to live 6 to 9 percent longer, a new study found... @carlzimmer @nytimes this pub with interviews by James White, Vadim @gladyshev_lab, @wysscoray, @davidjglassMD 🔗nytimes.com/2023/07/27/hea…

A team of scientists has extended the lives of old mice by connecting their blood vessels to young mice. The study found infusions of youthful blood led the older animals to live 6-9% longer, roughly equivalent to six extra years for an average human. nyti.ms/3OeVLP4

@davidjglassMD If you just read the titles, I would agree. The data buried in the paper didn’t warrant to article title, imho. Comparing the raw lifespan data of both models, the heterochronic old groups had remarkably similar degrees of change to median lifespan.

Great working with my co-1st Bohan Zhang! Total superstar! And glad to see Senior author Jim White getting more research out; tough starting a lab doing longevity work cause… well… life happens.

I was really impressed by that last “mock parabiosis” experiment (suggested during review but buried in Supp Fig 5). Whats the rejuvenation potential of young blood vs increasing physical activity and are those benefits maintained after the intervention is stopped?

It is (finally) out! Great teamwork on this paper about aging and rejuvenation! Young circulation is acutely beneficial for an aged organism but thats old news… how long does the system need exposure to young🩸for the benefits to persist? nature.com/articles/s4358…

And instantly an entire generation of grad students were allowed 4 more hours of sleep.

@SynBio1 And your PE+, GFP-

POV you are being fluorescence-activated cell sorted

@MuscleSciMegan @SkepticalDDS

@MuscleSciMegan @SkepticalDDS The person I work with most closely is a dentist and she loves her tooth themed desk things. Like 🦷 pencil holders or 🦷 magnets.

Twitter our RA is moving onto dental school soon and want to get a cute/fun going away gift with some kind of dental theme. Thoughts? @SkepticalDDS you know teeth stuff. Ideas?

@PhD_Genie “The upfront cost of the real time pcr machine is minimal but requires barcoded plates that expire within three weeks and wont run. Fortunately weve found a work around”

Give an academic heading to this video twitter.com/i/status/16381…

@NIHgrants @NIH “The NIH should score negatively institutions which employ vast numbers of postdoctorates that it doesn’t routinely (or by default) promote into PI/faculty roles. You would think poorly of a master carpenter whose journeymen it wouldnt, once trained, employ to build a house.”

@NIHgrants @NIH “If an institution is willing to employ postdoctoral researchers that it will not promote into faculty positions, the institution is effectively demonstrating it cannot offer research experience to the standard the institution itself sets”

Wait, ill join in on the discussion… I spent just 13 hours on a single R01……. Table.

Im gunna get in so much trouble when i show this to my statistician wife. 😂☠️