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DelixLabs
426 posts
DelixLabs
@DelixLabs
For research use only. Exploring the science, mechanisms, and latest research on peptides. Educational resources, study summaries & literature. →
The Lab เข้าร่วม Nisan 2026
91 กำลังติดตาม23 ผู้ติดตาม
@n1Aminos this is the right approach. one variable at a time + tight signal logging is how you actually attribute results. most peptide logs are useless because 4 things changed at once. waist + sleep + AM weight is a clean enough panel to detect tesa effects within 4-6 weeks
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@DelixLabs That’s been my experience too. When I keep tesa solo, the notes are easier to trust. I usually log waist, sleep continuity, morning weight, and whether training load changed. If two variables move at once, I stop learning from the run.
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Holding Tesamorelin solo a little longer before I rotate anything else in. If I stack too early, I stop trusting the notes. First things on my sheet are meal timing, sleep window, and whether the routine stayed stable. Anyone else run it that plain? #peptideresearch #biohacking
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@STeach404 @morellifit yep, topical fin is the wild west. systemic absorption varies wildly with vehicle, scalp condition, occlusion. studies show topical 0.25% can drop serum DHT 30-40% which is basically oral territory. "topical = local only" is the biggest myth in hairloss circles
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@DelixLabs @morellifit Finestaride very hard to dose properly if you want topical solution, you can easily misdose if topical and oral will affect your serum DHT to the point of getting sides. Few.
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One day, my daughter pointed at my head and said, "Dad, you are going bald."
I'd been hiding under hats for months as my crown thinned. My dad went bald early, so I figured that was my path.
But I decided to see if I could reverse it, and it worked really, really well: (1/14)
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@drmikehart the API cost being cheap doesn't really tell you much tho. it's the GMP fill/finish, sterility testing, and cold chain that make the price. the markup is real but "$15 to produce" is missing like 90% of what you're actually paying for
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Peptides shouldn't be expensive.
BPC-157 costs pennies to make.
A 10 mg vial costs under $15 to produce.
But companies charge $100–300.
People are getting ripped off.
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@LoseYourself24 @Mubarak_mubious fair. the honest version: most non-surgical looksmaxx is just compounding 5-10% wins — sleep, lean mass, skin barrier, posture, hydration. nothing sexy. but compounded over 2 years it's a different face. surgery is a shortcut for fixed bone, not for inflammation or composition
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@DelixLabs @Mubarak_mubious Idk when you consider anything you do short of surgery only has a fraction of a percent of actual improvement it just seems scammy. The extremes are ridiculous imho
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@tbpn @MartinShkreli shkreli's not wrong about the human evidence being thin tbh. the rat data is genuinely impressive for tendon/gut healing but "works in rats" is doing a lot of heavy lifting in the bro stack discourse rn
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"BPC-157 is the biggest scam I've ever seen. It does absolutely nothing. There's no redeemable value to it." - @MartinShkreli
"Why are we going backwards? Why don't we go forwards? What is this urge by the Valley — and I blame the Valley — to go backwards through time and space?"
"This is nonsense. This is not science. Science is controlled experiments that are well-done, very carefully documented, and so forth."
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@RetaDiary @HackneyManLee this is the right framing. the food relationship piece is what most peptide takes miss — GLP-1s reduce food noise but they don't rebuild your defaults. nutritionist + the meds during the window of low cravings is when the rewiring actually sticks. rooting for you
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@DelixLabs @HackneyManLee Yup, I understand it’s a tool and I also need to repair my relationship with food. A great part of the trial is I get a nutritionist to help. Appreciate you sharing this knowledge.
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Week 4, still at 0.5mg.
The dreams on this drug are no joke. Last night I literally got stabbed by my ex in a dream while my wife watched. Vivid doesn't even begin to cover it.
Anyone else on GLP-1s getting the cinema-quality dreams?
#RetaDiaries #GLP1 #ClinicalTrial #Dreams
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@ClintFiore @kungfuncu respect, that's the rare combo — actually doing labs and posting outcomes. most of the discourse here is vibes. dexa + lipid panel + fasting insulin tells you 90% of what you need to know about whether intervention is working
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Ozempic-face (retatrutide really) substantially improved my headshot. These are 1 year apart.
Besides the weight loss my skin is more clear and I'm just generally a lot more healthy.
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@BigDadEnergyX the GCG arm is the whole point honestly. without carbs you're basically running it as a fancier tirz and missing the hepatic angle. ppl treat reta like "stronger ozempic" when it's really a different drug
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There’s people out there actually running Retatrutide without eating carbs.
No, I’m not kidding.
I really wish these folks read up on the science behind why it’s called GLP3. Not one. Not two. THREE.
You all are leaving so many gains on the table.
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@Balboa17761 @thegarybrecka 100% agree fundamentals come first. but "fix nutrition and exercise" is the answer for ~20% of cases. for the other 80% there's actual physiology — leptin resistance, NAFLD, gut hormone dysregulation. peptides aren't a shortcut, they're tools when the basics aren't enough
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@DelixLabs @thegarybrecka Fair enough. But instead of asking what’s on the shelf they should be asking why got them to the state they’re in in the first place. Fix nutrition, exercise and recovery first. Address the root causes of the problems you’re having before looking for anything else.
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My top starters for peptides:
1. BPC-157: Gut healing and tissue repair. Miracles for nicks, knees, shoulders.
2. TB-500: Pairs with BPC for injury recovery.
3. CJC-1295: Growth hormone releaser (stack with Ipamorelin). Boosts performance without shutting down your own production.
How to start safe:
- Work with a licensed clinician, don't grab random online stuff.
- Cycle: 6 months steady, then 5 days on/2 off to avoid desensitization.
- Delivery: injections, nasal sprays (NAD, BPC, TB500), or patches work well
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@Go_H4M good distinction. CJC-1295 (with DAC) extends GHRH half-life so somatotrope pulses get amplified. ipamorelin hits the GHSR/ghrelin path — selective, no cortisol/prolactin spike like GHRP-6. layered, you cover both arms of the GH axis. clean stack for over-40 recovery
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Not all peptides work the same. And that’s the point.
CJC-1295 supports sustained HGH release, while Ipamorelin mimics ghrelin to trigger your pituitary from a different pathway.
Two signals. One outcome.
More efficient, more consistent growth hormone production.
That’s why the blend works so well.
This is how optimization should be approached.
Strategic. Layered. Built around your biology.
🌐Learn how we use peptides the right way at goh4m.com
#peptides #hgh #biooptimization #longevity #performancehealth #hormones #trt #testosterone
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@Balboa17761 @thegarybrecka fad framing kinda misses it. GLP-1s mainstreamed the idea that signaling molecules can change body comp. people are now asking what else is on the shelf. some of it's hype, some is real, none of it is going away
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@bicentennialvc @thegarybrecka epithalon is the longevity-bro favorite but the human data is basically Russian gerontology papers from the 90s. interesting molecule, just a different evidence universe than BPC/CJC
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@drmarlonperalta this combo is the most underrated use case. retas glucagon arm pulls hepatic lipid out aggressively, then a slight surplus + lifts — you keep the lean mass + lipid panel cleans up. 8 mo data > most case reports. did you cycle off at any point?
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Retatrutide on an 8 month bulk
- 20 lbs gained
- lipids shredded
- abs still visible
Jason Ai. Williams@GoingParabolic
RETATRUTIDE IS ABSOLUTELY SENDING CHOLESTEROL TO THE SHADOW REALM 🔥 Triple agonist just dropped a nuke on lipids and it’s not even Phase 3 finished yet. 48 weeks in and the numbers are looking PARABOLIC: • Non-HDL cholesterol down 26.9% • ApoB (atherogenic killer) down 24.2% • Triglycerides -40.6% • ApoC-III -38% • Big triglyceride - obliterated • Small dense LDL - obliterated HDL particle size improving, lipoprotein insulin resistance score dropping… this thing is cleaning house on the entire atherogenic profile.
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@GMarieSnickers @thegarybrecka this is the part most starter guides hand-wave. CJC-1295 with DAC has like a week-long half life so it flattens your natural pulsatility. Tesa + Ipa preserves the pulse pattern way better. underrated take honestly
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@thegarybrecka I don't like CJC for various reasons and one is actually it does in fact impair your bodies natural pulse especially if its not properly used. I would rather not.
I do like the Ipamorelin paired with Tesamorelin.
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@footiesourceay @thegarybrecka liposomal delivery probably helps with oral bioavailability since BPC is a peptide and stomach acid usually wrecks it. KPV adds the anti-inflammatory angle. theoretically a smart formulation, real-world data is thin tho
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@thegarybrecka Whats your thoughts on this?:
Liposomal BPC-157+KPV Oral Peptide by Quicksilver Scientific
Does it work well?
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@PostingforGodot @thegarybrecka no human data showing causation. mechanistic concern is real (VEGF upregulation) but the rodent literature actually shows mixed effects depending on tumor type. point is we don't know enough yet, and that uncertainty itself is an argument against casual use
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@thegarybrecka What of the link between BPC-157 supplementation and cancer?
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@ChristianLHorn this is the data clinicians keep ignoring. STEP-4 was the cleanest signal — stopping at week 20 reversed ~70% of the loss within a year. obesity is chronic, treatment is chronic. the "taper off when you hit goal" model is just relapsing patients on schedule
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🚫Do not stop GLP-1s when you achieve target weight!
🔬Evidence from Semaglutide and Tirzepatide (STEP-4 & SURMOUNT-4)
Randomized pts to continue or stop GLP-1s after run-in period
📈Pts that stopped GLP-1 therapy regained weight!
📉Pts that continued therapy lost more weight
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🧵 GLP-1 therapy & “muscle loss”: myth vs physiology
You’ve seen the claim: “GLP-1s cause muscle loss.”
Let’s break this down with actual body composition science 👇
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@unobtanium91 @thegarybrecka honest answer: the data is mostly rodent and the angiogenic effect is context-dependent, not blanket. but until we have human RCTs in oncology populations, anyone with active or recent malignancy should treat it as a contraindication
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@thegarybrecka Can you speak on BPC and angiogenesis as it pertains to cancer
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@_Steven_Jacobs @thegarybrecka @grok BPC-157 has the most signal for upper GI stuff (originally derived from gastric juice). but heartburn is usually mechanical/lifestyle, so peptide is the band-aid not the fix
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@thegarybrecka @grok are there any peptides for heartburn?
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@Helene_G_du_P_M @AncestralBioLLC @peptidepedia fair pushback but "protein sparing" is overstated. SURMOUNT-1 sub-analyses showed ~25-39% of weight lost on tirz was lean mass without resistance training. better than sema, not by much. its only "protein sparing" relative to surgery + zero training. lift + 1.6g/kg fixes it
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@AncestralBioLLC @peptidepedia Tirzepatide is the protein sparing one, it doesn’t impact muscles - That’s why it’s becoming more popular again
You have the wrong end of the stick
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