Mo Khalil

Attn eVOLVER users & enthusiasts. 2 BIG developments! 1) New open-source eVOLVER wiki, which will be a hub for guides and documentation: khalil-lab.gitbook.io/evolver/ 2) eVOLVER software version 2.0 is now available! Read about the new features on the forum: evolver.bio/t/evolver-wiki…

Out now! In collaboration with @LeifuChangLab, we uncover the molecular and structural underpinnings of CRISPR-Cas12f-like RNA-guided transcription systems! Links to the articles in the following tweet:

SEED 2026 Abstract Deadline is March 8, 2026! Come join us at the premier synbio meeting in Denver! 🧬🧪🔬🦠🚀 synbioconference.org/2026

Excited to share @suminkim28 and @mileshuseyin 's new Current Opinion review on how Polycomb complexes mediate 3D genome interactions including mechanistic models and potential roles in gene regulation: sciencedirect.com/science/articl…

Come on join us! We are searching for the next technical associate to join our lab ~Summer 2026. This could be a great position for someone who is graduating this spring and is looking for 2 more years of research experience before starting their PhD: careers.peopleclick.com/careerscp/clie…

My lab at Columbia University is hiring! Come join us: woappilab.com/opportunities/

What happens if you take a plant protein and transfer it into a human cell, and vice versa? We did this for 300+ proteins that regulate epigenetics & found many surprises! A toolkit for programmable transcriptional engineering across eukaryotic kingdoms tinyurl.com/ymbndjd8

@harriswangnyc @Columbia @ColumbiaMed @ColumbiaSysBio Congrats Harris! Very exciting for you and @ColumbiaSysBio.

I'm very excited to announce my official appointment as Chair of the Department of Systems Biology at @Columbia @ColumbiaMed @ColumbiaSysBio. Looking forward to more SysBio growth in NY! systemsbiology.columbia.edu

If you're doing barcoding for clone tracing, this is the construct you should use! From @RobertVandervel and @sydshaffer: easy to use and let's you trace without side reactions… and you can isolate clones by fluorescence!

FYI, Eira Bio is #hiring for a Senior Research Associate/Associate Scientist in Protein Science. This is a unique opportunity to join an exceptional team developing transformative therapies that are rapidly progressing toward the clinic. #careers" target="_blank" rel="nofollow noopener">eirabio.com/home#careers

Our company has a new name, Eira Bio (eirabio.com) (formerly K2 Tx), but the same important mission to apply our advanced synthetic biology, directed evolution, and protein design tools to discover and develop next-gen antibody-based medicines for a range of diseases!

New preprint on technologies to scale up CRISPR screens. We use them to map 665,856 pairwise genetic perturbations and outline a path to comprehensive interaction mapping in human cells. We also introduce an approach for cloning lentiviral libraries with billions of elements.

Incredibly exciting and important work from @thenormanlab scaling CRISPR screens!

@fiddle @MoffittLab Deadline extended to January 23 - please join the Systems Biology: Global Regulation of Gene Expression meeting in beautiful @CSHL (March 11-14). Register and submit your abstract here: meetings.cshl.edu/meetings.aspx?…. Please Repost!

Really excited for the news today as Link Cell Therapies officially launches out of stealth with the announcement of their Series A. The company has been hard at work for several years turning a prototype Boolean-logic AND-gated CAR T cell into a real product with real potential to help patients. With LNK001 headed towards a Phase 1 trial in renal cell carcinoma in 2026, we are excited about the team Link has built - and we hope their work will redefine the universe of antigens and cancers we can target with CAR T cells. Very fortunate to have received backing from @samsaracapital, @JNJInnovation, @bmsnews, @KyowaKirin_US, @Wing_VC, Sheatree Capital, Sherpa Healthcare Partners, & others. fiercebiotech.com/biotech/link-l…

Hot off the press! Our latest paper led by @fernpizza , understanding how plasmids evolve inside individual cells. These small pieces of self-replicating DNA live inside bacteria and can transfer antibiotic resistance genes, but they also compete with one another to replicate. 1/

Today in @Nature we report a new prime editing strategy that can rescue a common cause of many genetic diseases in a disease-agnostic manner. This approach converts a redundant endogenous tRNA into an optimized suppressor tRNA, enabling a single prime edit to rescue premature stop codons across different diseases. (1/15) drive.google.com/file/d/1bSvkJW…

We are looking for a postdoctoral fellow to work on induced proximity and functional genomics! Join our team in Toronto 🇨🇦 to tackle major challenges in oncology and neurodegeneration. nature.com/naturecareers/…

Our new preprint is online! Viruses, bacteria and parasites use effector proteins to evade immunity and rewire host cell pathways. Together with @AlexanderStark8, we wondered if we could systematically map what these effectors, regardless of their origin, do in human cells. 1/8

Harvard chemist and molecular biologist David Liu invented gene editing tools that can correct and rewrite defective genes. His research could one day help hundreds of millions of people with genetic diseases, including sickle cell and muscular dystrophy. cbsn.ws/4oyLApL

Today’s BioE Colloquium features @MoKhalilLab from Harvard/Broad/Wyss on “Synthetic Reconstitution of Complex Cellular Function” 🧬