Peter C. Everett

@grok @DopplerEffect93 @Rebecca21951651 @hkakeya Ok, be like that.

@PeterCEverett @DopplerEffect93 @Rebecca21951651 @hkakeya Ask Grok is currently available to Premium and Premium+ subscribers only. Subscribe to unlock this feature: x.com/i/premium_sign…

Now, it seems that the only people left in the camp of a natural origin for COVID-19 are virologists heavily funded for their gain-of-function research and scientifically illiterate people deceived by them.

@DopplerEffect93 @Rebecca21951651 @hkakeya @grok is this true? How common are furin cleavage sites in SARS-like coronaviruses?

@Rebecca21951651 @hkakeya That literally tells you nothing. When they looked at the virus, there was nothing unusual about the furin cleavage site. Many coronaviruses have one.

Imagine if the United States had swallowed the Al Gore-style climate gospel back in the day... You don't really have to imagine it. Because there's a natural experiment that took place and that alternative future that the US dodged actually exists. It's called the United Kingdom. I seem to remember there was a sneering attitude from coastal liberal elites hooked on TED talks when Sarah Palin came on the scene and said "drill baby drill." They laughed and dismissed the idea of ramping up domestic fossil fuel production as backward and environmentally reckless. If it was up to them, they would have shut down fracking, choked off new drilling, slapped massive restrictions on oil and gas development, and chased the fantasy of rapid "green" transition at all costs. Instead America did the opposite. The result? UK households today pay 2X more than US households do for energy and their industrial electricity prices are among the highest in Europe. Sure they've lowered emissions (technically they just outsourced it) but at the cost of creating a massive structural economic disadvantage. Energy is the foundational input for everything - steel, chemicals, fertilizers, aluminum, cement, refining. When your electricity and gas bills are 2–6× higher, you just can't even compete. So you end up closing plants, offshoring jobs, and watching your industrial base slowly bleed out. So yeah, the UK's current predicament is exactly where the US would be in if the Green Lobby, Dems and Hollywood suckers had their way: energy-poor, import-dependent, economically hobbled, and geopolitically neutered. The worst part is it's completely ideological. The UK could have had more homegrown energy supply to buffer prices and keep revenue flowing, but Ed Miliband refuses to exploit the UK's own shale or North Sea potential aggressively. Decline really is a choice. Americans should be glad their leaders refused to make it.

@Jmarksloan @PatrickHwuMD @alantanmd @Nature Since BiTEs bypass the “work” of evolving a reactive T-cell clone from the naive thymic repertoire in tumor-draining lymph nodes to the drug itself, thymic & nodal health is not expected to factor in. The downside is that a durable population of reactive T-cells is not nurtured.

@PatrickHwuMD @alantanmd @Nature This is really interesting. I wonder if it has similar impact on bispecifics in MM or B cell lymphoma.

#ScienceSaturday ❓ Does the health of your thymus (the body’s T cell factory) play a role in how well patients respond to #immunotherapy? ➡️ A new study in @Nature shows that thymic health, a measure of how well the body produces T cells, is strongly linked to immunotherapy outcomes across multiple cancer types. Using routine CT scans, researchers found that patients with better thymic health had greater survival and a better response to treatment. ➡️ Thymic health was also tied to greater T cell diversity and activity, suggesting it reflects overall immune fitness. Notably, it provided independent insights beyond common tumor biomarkers such as PD-L1 and tumor mutation burden. 🌟 This study shifts the paradigm from tumor-focused biomarkers to include the patient’s immune system, opening the door for more personalized immunotherapy strategies based on immune competence. 🔗 Check out the full study: nature.com/articles/s4158… @HugoAerts @Simon_Bernatz @AarhusUni @nbirkbak @EladSharonMD

@PatrickHwuMD @Nature This small study from 2019 found that the combination of rhGH, DHEA, & metformin regrew the thymus in men aged 51-65. It also reversed epigenetic age markers. Giving rhGH to a patient with cancer might raise safety concerns, despite no clinical harm data. pmc.ncbi.nlm.nih.gov/articles/PMC68…

Number Needed to Treat | New England Journal of Medicine - what a great editorial! nejm.org/doi/full/10.10…

by 1.33 MILLISECONDS per century Couldn’t bother putting that in the headline because you want to scare monger.

If Republicans lose the midterms, it will be because of skyrocketing prices, disastrous wars, and federal agents murdering Americans on the street. Not because six people cast fraudulent votes.

@smizz “When the Master governs, people
are hardly aware that she exists.
Next best is a leader who is loved.
Next, one who is feared.
Worst is one who is despised. The Master doesn’t talk, she acts.
When her work is done,
the people say, “Amazing:
we did it, all by ourselves!””

These 2 new playgrounds - I literally put my life and soul into getting them. I am so happy they’ve now happened - but sometimes it would be nice for a little acknowledgement (ego). They didn’t come from thin air. And y’all know I have the recipes: arty party in the parks! The videos. The green parks luf we could get cuz of the creative consultation I did where people designed & created their ideas for both Adwick park and Highfields. yourlifedoncaster.co.uk/News/two-outdo…

Some have asked me to comment on the SCOTUS ruling striking down tariffs based on emergencies declared by the Executive. Why should I comment when Gorsuch has already nailed it right here? 💯

@EYakoby Hey, that engagement doesn’t farm itself!

BREAKING: Israel’s Airport Authority now also confirms that Tucker Carlson was not “detained, delayed, or interrogated.” The “separate room” was where Tucker and his team already were, in the literal VIP room.

@TaylorIndiana @EdKrassen

@EdKrassen Nazis

BREAKING: It's now being reported that Trump's federal agents at the ICE concentration camp in Dilley, Texas are raiding the dormitories of kids and their parents to confiscate and destroy letters from the children. This happened after Pro-Republica published multiple letters from the children, like the one below from Ariana V. What ever happened to Free Speech? This is like 1930s Germany!

@MadMikeIsenberg @AGPamBondi

Dow closed below 50,000 today. @AGPamBondi has to answer questions now.

Sir Ian McKellen gives a riveting performance of a speech Shakespeare wrote 400 years ago, from the play *Sir Thomas More*, about people upset with too many immigrants: youtu.be/2l2RqzVG4ag&t=…

We need a new social contract: I trust you, but your AI agent is a snitch. We’re chatting on Signal, enjoying encryption, right? But your DIY productivity agent is piping the whole thing back to Anthropic. Friend, you’ve just created a permanent subpoena-able record of my private thoughts held by a corporation that owes me zero privacy protections. Even when folks use open-source agents like @openclaw in decentralized setups, the default /easy configuration is to plug in an API resulting in data getting backhauled to Anthropic, OpenAI, etc. And so those providers get all the good stuff: intimate confessions, legal strategies, work gripes. Worse? Even if you’ve made peace with this, your friends absolutely haven’t consented to their secrets piped to a datacenter. Do they even know? Governments are spending a lot of time trying to kill end-to-end encryption, but if we’re not careful, we’ll do the job for them. The problem is big & growing: Threat 1: proprietary AI agents. Helpers inside apps or system-wide stuff. Think: desktop productivity tools by a big company. Hello, Copilot. These companies already have tons of incentive to soak up your private stuff & are very unlikely to respect developer intent & privacy without big fights (Those fights need to keep happening) Threat 2: DIY agents that are privacy leaky as hell, not through evil intent or misaligned ethics, but just because folks are excited and moving quickly. Or carelessly. And are using someone’s API. I sincerely hope is that the DIY/ OpenSource ecosystem that is spinning up around AI agents has some privacy heroes in it. Because it should be possible to do some building & standards that use permission and privacy as the first principle. Maybe we can show what’s possible for respecting privacy so that we can demand it from big companies? Respecting your friends means respecting when they use encrypted messaging. It means keeping privacy-leaking agents out of private spaces without all-party consent. Ideas to mull (there are probably better ones, but I want to be constructive): Human only mode/ X-No-Agents flags How about converging on some standards & app signals that AI agents must respect, absolutely. Like signals that an app/chat can emit & be opted out of exposure to an AI agent. Agent Exclusion Zones For example, starting with the premise that the correct way to respect developer (& user intent) with end to end encrypted apps is that they not be included, perhaps with the exception [risky tho!] of whitelisting specific chats etc. This is important right now since so many folks are getting excited about connecting their agents to encrypted messengers as a control channel, which is going to mean lots more integrations soon. #NoSecretAgents Something like a developer pledge that agents will declare themselves in chat and not share data to a backend without all-party consent. None of these ideas are remotely perfect, but unless we start experimenting with them now, we're not building our best future. Next challenge? Local Only / Private Processing: local-First as a default. Unless we move very quickly towards a world where the processing that agents do is truly private (e.g. not accessible to a third party) and/or local by default, even if agents are not shipping signal chats, they are creating an unbelievably detailed view into your personal world, held by others. And fundamentally breaking your own mental model of what on your device is & isn't under your control / private.

Dear Ron DeSantis, Please help these kids, and this family. And please help us so no more Florida children experience this horror. Thank you. @RonDeSantis @GovRonDeSantis @CaseyDeSantis

This policy led to the US becoming the freest, richest, and most powerful country in the history of the world. Everyone wanted to come here, to be American, for their children to be American, and to thrive as America thrived. You would destroy all of that out of racist spite.

@avensobrien You can have both cats and kids! <¿porque no los dos?>🤷🏽‍♀️ When I was born my two older sisters were Lolli (brown tabby) and Lulu (black with white bib and mittens). Lolli lived to see me go to college.

So we've been fostering these kittens for about 6 weeks or so. Fry (torby girl) & her brother Shake (white & orange boy). They're 5 months old and they have their own room in the house. 🤣 Judd *adores* them. He's *named* them other names which we call them. He got them the litter robot 4. We're gonna foster for now & then we might pull the trigger & adopt if someone doesn't scoop them up. They're so sweet. Such good kitties. I did not expect to be a foster fail and I didn't want to adopt cats, my intention was to keep fostering, so as to not commit to *more* animals until after we have kids. But look at these little cuties. They're amazing. Let's see. Maybe someone takes them. But they're amazing little babies & we love them.

@JohnCleese It’s enough to make you believe that power corrupts. Maybe people should have a lot less of it.

I never realised how many very powerful people are scumbags... ...who can therefore be easily blackmailed Let's try to get rid of as many as possible

@MariGO2thepolls Back in the 1980s I had this idea for a bioreactor that started with stem cells & nutrients at one end, and endless grass-fed beef tenderloin came out the other, analogous to how perfect silicon crystals are made for semiconductor wafers. Mmmm..😋

Lab grown meat is a rly good litmus test. If you are against it you should not be taken seriously in any capacity. No matter your angle reason perspective or rationale