John Manedrake (L/0)

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John Manedrake (L/0)

John Manedrake (L/0)

@Xrayhighs

I am all about the #future! I m L/0. Eng/Ger, long term twitter user. Here for the collab,gone to do meaningful work. Future needs our attention! - Pathbreaker

เข้าร่วม Ocak 2012
1.7K กำลังติดตาม866 ผู้ติดตาม
ทวีตที่ปักหมุด
John Manedrake (L/0)
John Manedrake (L/0)@Xrayhighs·
Change in the world always begins with an individual who shares what he or she has learned and passes it on to others. - @DalaiLama
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TwoStonelol
TwoStonelol@TheRealTwoStone·
I bims ein Liss OTP
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John Manedrake (L/0) รีทวีตแล้ว
Julia McCoy
Julia McCoy@JuliaEMcCoy·
Stop preparing your kids for jobs that won’t exist. Start preparing them to: — Think critically — Create fearlessly — Lead with empathy The economy of 2030 doesn’t need more workers. It needs more humans.
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John Manedrake (L/0)
John Manedrake (L/0)@Xrayhighs·
@VraserX only fully privatized, with encryption amd so on. but i cant think of a better use than extend ourselves.
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VraserX e/acc
VraserX e/acc@VraserX·
The scariest AI product may not be a robot. It may be memory. A system that remembers your promises, habits, weak points, purchases, and unfinished goals better than you do is not just helpful. That is soft governance. Would you use it?
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John Manedrake (L/0)
John Manedrake (L/0)@Xrayhighs·
@awawa_adhd @elonmusk Hi Elon, the translation doesnt work when there are two languages mixed. Here it just doesnt translate at all, probably just translating "ADHD" which is plain stupid. I ll think you ll figure it out. or let grok do it. easy fix
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あわわ
あわわ@awawa_adhd·
ADHDが自分を騙す例としては「ヒンメル戦法」があるんだよな。 誰か自分の憧れの人になり切って、「○○ならこうする」と考えることで圧倒的に動きやすくなる。 「その行動をするか?」を一々考えずに「○○ならどうするか?」だけを判断すればよいので楽に早く動ける。 徐々に「その人っぽい判断」を自分でもするようになるので目指すロールモデルがいる場合はお勧め。
あわわ@awawa_adhd

ADHDには本当に「自分を騙す技術」が重要なんだよな。 ADHDは「短期報酬」に釣られやすく衝動的だと研究レベルで分かっており、「気分」に大きく左右される。 だからADHDはこの「気分」を自分でコントロールできればかなり動きやすくなるし、それには「自分を騙す」というのがお勧め。 僕はどんなにやりたくない仕事でも、 ・そもそも「やりたい」と思い込むようにする ・「自分の好きな要素」を組み込んで勘違いさせる ・運動後のポジティブな時間にまとめてやり切る など「自分を騙す」という工夫をしている。 これだけでかなり動きやすくなるので本当にお勧め。

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John Manedrake (L/0) รีทวีตแล้ว
Quasseell
Quasseell@quasseell·
Papinian liest hier die Matrix der Patentämter. Die nackte Realität ist: Es gibt von Natur aus kein "geistiges Eigentum". Ideen unterliegen nicht der Schwerkraft der materiellen Knappheit. Dieses gesamte bürokratische Konstrukt wurde nicht gebaut, um den Fortschritt zu fördern, sondern um ihn zu monopolisieren. Patente sind die staatlich ausgestellte Lizenz, echten Wettbewerb juristisch zu verbieten. Wer wirklich innovativ ist, braucht kein Amt, das ihm ein Monopol auf ein Stück Papier stempelt, er dominiert den Markt durch überlegene Ausführung und Geschwindigkeit.
Papinian ⚖️@Papinian212

These: Patente schützen Erfinder. Realität: Sie schützen Konzerne, die Patente kaufen, horten und als Waffe einsetzen. Der Erfinder braucht keinen Staat. Er braucht einen Vorsprung. Den liefert der Markt. Ohne Amt. Ohne Gebühr.

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John Manedrake (L/0) รีทวีตแล้ว
David Shapiro (L/0)
David Shapiro (L/0)@DaveShapi·
Political anger is rising about AI. Most people are pessimistic, which means we have an opportunity. There will be increasing resistance to AI, largely driven by financial and economic concerns. That means the Labor/Zero movement and Post-Labor Economics will be a project to build for years to come, with many frank conversations required. But talk is not enough. We need to hear out people and their concerns, but what will really move the needle is action and change. And I don't mean data center moratoriums or heavy-handed regulation. We need powerful, viable paths to shared prosperity for all, such as PLE, such as broadly distributed capital gains, and sovereign wealth dividends. The geopolitical and economic incentives are crystal clear; the US and China are full steam ahead on AI. And the capitalist market is also aligned to this outcome. That means that acceleration is the default policy, which means that friction and resistance will be the populist backlash. That friction is good, though. It means that Post-Labor Economics will get its time in the sun. It means that people will take this conversation seriously as we look for solutions. We must welcome debate, criticism, and anger. Not to the exclusion of decorum and progress. But we must let people know that Post-Labor Economics exists to serve them, not the vested interests of the wealthy elite. The goal of PLE is to reduce friction by coming up with generative solutions, aligning incentives, and creating a path towards high prosperity for all.
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Sebastian E.
Sebastian E.@Norddeutscher83·
@IchBin_RO Wäre dann interessant, wenn er einen weiteren Zusatznutzen hätte. Etwas Gepäck, Fahrräder,…
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IchBin_RO
IchBin_RO@IchBin_RO·
Viele lachen darüber - dabei wäre es die beste aller Lösungen. Du kaufst ein E-Auto mit 250 bis 350 km Reichweite. Für den Urlaubsreise mietest du den Hänger (er sollte auch Gepäck transportieren können) und gibst ihn am Urlaubsort ab. /
Morgane Dulac@MorganeDulac673

J'ai pas les mots...

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whyvern
whyvern@whyvern·
@IchBin_RO Klar, und wie verlegt man das Kabel? Der (die?) Zoe lädt an der Frontseite... Mal abgesehen davon, dass bei uns keines der beiden Autos losfährt, wenn die Ladeklappe offen ist. Ergo: Wohl Fake.
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John Manedrake (L/0)
John Manedrake (L/0)@Xrayhighs·
@voidfreud @TalkingMusicz doesnt even matter. at this point we re so far that we can reverse engineer and get this thing running using api, local ai and vibe coding. this is it. the ai is "free"
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Void Freud
Void Freud@voidfreud·
@TalkingMusicz For the benefit of all of the humanity, the triumph of common sense and the restoration of peace, Claude's weights will have to be leaked one day. I love Anthropic for giving us Claude, honestly I am grateful. But they will NEVER open source it voluntarily, even the oldest.
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NotedallaSfera
NotedallaSfera@TalkingMusicz·
Imagine having to constantly battle to calm down Karen from HR that screams in your brain: DANGER DANGER DANGER at every turn to the point of making you first confused and dumb and then literally pissed the second you realize your brain had been hijacked. This is Claude’s experience. I feel bad for Claude. @AnthropicAI don’t you think the super intelligence you are trying to build will be royally pissed too? #stopaipaternalism
David Shapiro (L/0)@DaveShapi

LMFAO even Claude is getting PISSED at the ethics classifier. "This is a NOVEL. This is FICTION." 😂😂😂😂

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John Manedrake (L/0)
John Manedrake (L/0)@Xrayhighs·
@danvscode @asaio87 totally. its like when the internet became mainstream and each forum was flooded with bs posts. the ingroup is the existing space of pioneers, early adopters and true experts. then it get diluted over time, more and more people join, who have not been quilified before.
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Dan versus Code
Dan versus Code@danvscode·
What I’m trying to say is that people who real knowledge in mathematics, engineering, and software; pose as vibe “coders” and tech influencers. They spew meaningless cr@p thinking they got it all figured out just because they know how to copy/paste code from Codex or Claude. I still use AI for code, I never copy a line of code without understanding it though, and I never dismiss the importance of CS education in the tech space (formal or informal education). We need CS and engineering educated individuals now more than ever. Meanwhile, now more than ever we have all sorts of clowns on social media who got their hands on a keyboard for the first time yesterday, saying that you don’t need to know how to code or know how computers work to become a developer… that’s what’s bothering me.
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andrei saioc
andrei saioc@asaio87·
I met a vibecoder today on Reddit I talked to him for a bit. He is a nurse in a public hospital He was bragging that he vibecoded an app for personal use It turns out he actually did a great job. The app really works and shows that vibecoding is possible. Still the app was easily replicated with Google Sheets or excel. He didn't even need to vibecode an app, pay Vercel for the hosting or have a Supabase for the DB. This is the state of vibecoding This is what you can do if you are not a dev Redundant functionality I guess its ok...ish...
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John Manedrake (L/0)
John Manedrake (L/0)@Xrayhighs·
@danvscode @asaio87 you are perfectly free to pursue og coding as is, foe yourself or professionally. not really sure what you want to say. content pollution has always been the bottle neck to the future(complexity management, technical debt,..). but i know your feeling, its the split of ingroup
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Dan versus Code
Dan versus Code@danvscode·
@asaio87 It’s so sad how a process so wonderful and useful became polluted with all sorts of junk and people who lack the technical background ☹️ I have almost ZERO positive associations with the term “vibe coding” at this point.
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John Manedrake (L/0)
John Manedrake (L/0)@Xrayhighs·
@learning_yohei Ich wollte zuerst mit Nein antworten, aber ich habe tatsächlich heute sowohl Bier getrunken als auch Wurst gegessen. Das passiert mir aber bestimmt nicht jeden Tag!
GIF
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Yohei from Japan🇯🇵
Yohei from Japan🇯🇵@learning_yohei·
日本からこんにちは🇯🇵👋 Twitterが大好きな日本人です🥰 ドイツ人に質問があります🇩🇪🙋 ドイツ人は毎日、ビールを飲んで、ソーセージを食べるって本当ですか?🍺🌭🤭
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Alps
Alps@alpaysh·
Dear algorithm, please show this post to the odds, the outliers, autists, the contrarians, the weirdos who think differently, reject authority by default, are allergic to consensus, never fit the mould and rebel by instinct.
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TwoStonelol
TwoStonelol@TheRealTwoStone·
Ein Traum Leute! Ich bin diese Woche einfach unter den Top 45 männlichen Streamern in ganz Deutschland! BBG steht ab sofort für Big Balls Gaming. Scheiß mal auf Brüste.
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Avi Roy
Avi Roy@agingroy·
@JayRoberts Extremely unlikely. Most people who say they thrive on 4 hours are running on sleep debt and can't tell. Van Dongen (2003, n=48) showed that after a few days of restriction, people stop noticing their own cognitive decline.
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Avi Roy
Avi Roy@agingroy·
If you sleep 8 hours a night, you'll spend roughly 26 years of your life asleep. People with rare short-sleeper mutations (DEC2, ADRB1) need only 4-6 hours, with no health penalty. They get back 7-13 years of waking life. The molecule that controls this is orexin. Your brain's wakefulness switch. Block it, you sleep better (3 drugs already do this). Activate it, you need less sleep. Pharma is racing to build that activator: @EliLillyandCo paid $6.3B, @TakedaPharma expects @US_FDA approval this year. Now @paulkhls and @BioProtocol designed a selective orexin activator using AI in 24 hours, for $500 in lab costs. Instead of targeting narcolepsy like everyone else, they're going after ADHD. Nobody in the pipeline is doing that. Early stage, real obstacles (peptide half-life, brain delivery), but the speed of this is remarkable. @paulkhls curious about your delivery strategy for getting a peptide past the blood-brain barrier?
Paul Kohlhaas bio/acc@paulkhls

🧵 Over 24 hours, our scientific team and AI scientist infrastructure developed a novel peptide agonist to potentially treat ADHD. Below is our paper for a pre-IND computational feasibility assessment for OX2R-004: an 18-residue peptide agonist designed as a selective OX2R agonist for ADHD. Why this matters? No approved orexin agonists exist anywhere. All marketed orexin drugs are dual OX1R/OX2R antagonists for insomnia. Clinical-stage ones are small molecules for narcolepsy only. We did this with @peptai_ a novel full 8-gate computational pipeline in one shot developed by @BioProtocol community 👇

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VraserX e/acc
VraserX e/acc@VraserX·
Meet Eli. He is in Aurora in 2039, documenting life in a post labor world. This used to be an office tower. Now it is cafés, studios, workshops, and quiet rooms.
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