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“If Mark Scheifele doesn’t make it, it will be the biggest omission that team Canada has had since 2006 when they didn’t take Sidney Crosby” 🇨🇦
- @CraigJButton
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Team Canada executive management should not include current employed NHL GM’s and coaches. The obvious bias that exists in their decisions is a detriment to the overall team.
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Mark Scheifele should be on Canada’s Olympic team!
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Reagan vs. Trump on Tariffs: The Gipper was a free trader, no matter what the current President says.- WSJ wsj.com/opinion/reagan…
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@TorontoHydro UPDATE: Crews have determined that a raccoon made contact with our equipment at a downtown Toronto station. We’re in the process of working with @torontohydro to restore power. We appreciate everyone’s patience.
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Excited to share our work on genome editing for SMA in @ScienceMagazine! We evaluated dozens of strategies targeting SMN2 regulatory sequences to rescue SMN levels, and show that one-time in vivo co-administration of our top strategy with nusinersen extends lifespan of SMA mice.
David R. Liu@davidrliu
Today we report in @ScienceMagazine a one-time base editing treatment for Spinal Muscular Atrophy (SMA), the leading genetic cause of infant mortality worldwide, affecting ~1 in 10,000 births. science.org/doi/10.1126/sc… PDF: drive.google.com/file/d/1H1k8AA… 1/17
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@davidrliu @MandanaArbab @DaveArnoldLab @Gregory_Newby @MichelleRicht14 @kevintzhao93 @maxwshen @broadinstitute @HHMINEWS @HarvardCCB @OhioState Amazing, congrats! Is someone going to work to bring this into humans? If we know someone who would be a good candidate, can we register them somewhere ?
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This work was a major collaboration led by @MandanaArbab (starting her own lab this summer at Boston Children’s Hospital/HMS, arbablab.com) and Zaneta Matuszek, including Arthur Burghes’s lab, Guangping Gao’s lab, Jun Xie’s lab, Dan Wang’s lab, and @DaveArnoldLab 17/17
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Today we report in @ScienceMagazine a one-time base editing treatment for Spinal Muscular Atrophy (SMA), the leading genetic cause of infant mortality worldwide, affecting ~1 in 10,000 births. science.org/doi/10.1126/sc…
PDF: drive.google.com/file/d/1H1k8AA…
1/17
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What’s your prediction for final GMV numbers at the end of BFCM?
Closest guess wins shopify.supply goodies!
tobi lutke@tobi
Some extra Shopify BFCM data: Purple is this year’s GMV Looking strong despite the macro economical pessimism. That’s great news for independent commerce!
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Tonight’s Leader Bank Leader is Rafael Devers, who leads the American League in hits with 112. Brought to you by @LeaderBank.
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Ouch. Inflation is far too important a problem for the White House to keep making statements like this. It’s either straight ahead misdirection or a deep misunderstanding of basic market dynamics.
President Biden Archived@POTUS46Archive
My message to the companies running gas stations and setting prices at the pump is simple: this is a time of war and global peril. Bring down the price you are charging at the pump to reflect the cost you’re paying for the product. And do it now.
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@brennahughesmd @PalatnikAnna Would you still recommend Paxlovid in pregnancy if triple vaccinated and minimal symptoms?
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@brennahughesmd and other colleagues with expertise in COVID-19 and pregnancy- do you give paxlovid and molnupiravir to pregnant patients? I saw the SMFM statement about paxlovid but not the other drug. Thank you
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💊Changes to Paxlovid access:
Higher-risk groups eligible for PCR/assessed for antiviral treatments:
-18+ who are immunocompromised
-70+
-60+ fewer than three vaccine doses
-18+ fewer than three vaccine doses and at least one risk condition
news.ontario.ca/en/release/100…
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@ONwxchaser @alluringstorms How far North do you think we need to go to see it?
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