timisstuck

asking people to read ai-generated text is offensive. this is not because ai text is intrinsically bad. rather, the author has not paid a cost to write the text himself. this cost is a credible signal he finds its communication important. so: not paying that cost is telling

发现个科研绘图神器！ nature-skills，用 matplotlib 就能画出 Nature 级别的图。多面板布局、配色、字体、排版都给你整得明明白白，直接输出可编辑的 SVG。 内置了 5 套 Nature 风格的示例模板，支持柱状图、折线图、热图、散点图、雷达图等 10 种图表类型。再也不用画完图再丢 AI 里重绘了。 搞科研写论文的，这个能省不少事儿，画出来的图直接能投稿。 项目地址放评论区了👇

Big takeaway: cellular expression patterns matter. mRNA expression in hepatocytes and myocytes shapes the immune response. Surprisingly, direct expression in DCs is not required—antigen can be transferred to them. Important implications for mRNA vaccine and drug design. (2/3)

RevMed just doubled overall survival in pancreatic cancer by using CypA-targeting molecular glues to potently drug oncogenic KRAS-ON, long deemed untouchable. One funny thing is that probably the most fundamental insight for daraxonrasib sits in a PNAS paper that's been cited merely 84 times. This showed that molecular glues can coax an endogenous protein to wrap itself around utterly featureless surface. The other is a 2017 Cell Reports paper (just 68 citations) on how Sanglifehrin A can be used to repurpose CypA's surface. A lot of the game-changing stuff seems niche and unglamorous at first. Greg Verdine is having a chembio Annus Mirabilis for his 2025-2026 streak: FOG-001, Daraxonrasib. He provided much of the foundational conceptual work behind taking out both Beta-catenin and KRAS*. *of course many others contributed immensely, but let's give some credit where credit is due!