Sam Tipps

🥁 Our manuscript "Multistate and functional protein design using RoseTTAFold sequence space diffusion" is finally out @NatureBiotech! 🧵b/c it's changed a LOT since preprint! New highlights: - High res structures - Conditionally caged peptides - Multistate design

Congrats masa!!

Water is 70–80% of a cell, with our mspSA + SGAG affinity grid, we capture a near atomic (<2 Å) view showing water actively driving gene transcription inside RNA Pol II. Not just background,water is part of the machinery. Now published in Molecular Cell.doi.org/10.1016/j.molc…

We benchmarked Arc Institute’s “MULTI-evolve” and found evidence that it learns a classical additive model, not epistasis. Preprint: biorxiv.org/content/10.648… Blog: dewitt-lab.github.io/posts/2026-04-…

📢 We’re launching Proteina-Complexa — and after the Jensen keynote mention, we definitely had to post this thread now ;) Atomistic binder design with generative pretraining + test-time compute, plus large-scale wet-lab validation. Project page: research.nvidia.com/labs/genair/pr… 🧵 1/n

AFDBにNVDAデータセットとして複合体が追加されましたね 高信頼度のみでホモダイマーばっかですけど色々使えそう

Now online! High-resolution in situ structures of hantavirus glycoprotein tetramers dlvr.it/TRCff9

Nature research paper: The political effects of X’s feed algorithm go.nature.com/4cIdYT0

The AlphaFold Database, jointly developed with @GoogleDeepMind, now contains datasets from specialist communities. This includes rich datasets for microbes, viruses & parasites associated with tropical diseases. ebi.ac.uk/about/news/upd…

How short can a degron be? We report a 9–aa, genetically encoded, tunable degron that drives MDM2-dependent degradation and enables precise control of endogenous protein levels. Thanks to @EswarappaLab for the opportunity to explore this in yeast. #Degron #yeast #cellbiology

Check our new preprint! We uncover the full molecular mechanism of rotavirus membrane penetration and cytosolic escape using cryo-ET, live-cell imaging, and single-molecule assays. (1/3) 🔗 biorxiv.org/content/10.648…

プレプリントを公開しました。タンパク質のアミノ酸配列を”編集”する方法についての研究です。 “Programmable protein editing by split intein-mediated recombination” biorxiv.org/content/10.648…

De novo design of metalloproteases for targeted amyloid-β cleavage biorxiv.org/content/10.648… #biorxiv_synbio

Papers submitted on Tuesdays are more likely to be accepted by Nature whereas Wednesdays seem the most likely day to submit and secure acceptance to PLOS ONE. For Cell, Mondays and Tuesdays seem the best submission days in case of accepted papers. link.springer.com/article/10.100…

New online! High-resolution cryo-EM meets parasitology in structural models of the conoid from Toxoplasma bit.ly/3YmxGvu

Computational design of orthogonal TCR α/β interfaces for dual-TCR therapeutics biorxiv.org/content/10.648… #biorxiv_bioeng

Happy New Year! We are delighted to share with you our newest @biorxivpreprint, in which we describe the de novo design of protein nanoparticles with structures tailored to specific applications. Long a dream, it is now reality! biorxiv.org/content/10.648…

🚨Today in @NatureComms: We resolve an enduring enigma in T cell biology—how TCR binding to p/HLA triggers intracellular signaling. CryoEM in native environment reveals a 'jack-in-the-box' mechanism! Collab btw @RockefellerUniv @MSKCancerCenter @parkerici rdcu.be/eUPPl

Researchers use #AI and Reverse Vaccinology 2.0 on human blood samples to identify a potential new mpox target, and use the target in a vaccine that elicited mpox-neutralizing antibodies in mice. @ScienceTM scim.ag/4iQkBUy

@aidenosinetrip1 @sokrypton @MazAbulnaga Super cool work Aiden, glad to see this out! Didnt know about the ability to find rewired proteins, I wonder what else it can detect 🤔

Excited to share my recent work, CIRPIN 🐍 with @sokrypton and @MazAbulnaga on the discovery of thousands of naturally occurring circularly permuted protein domains