Goran Markovic

@PeterDiamandis If you read the book Scale, written by J.B. West, you will see that lifespan is more than just treatment of hallmarks of aging

Longevity 2.0: Your next doctor won't prescribe pills—they'll prescribe gene therapies, epigenetic reprogramming, and personalized longevity protocols. Medicine is shifting from "treat symptoms" to "reverse aging at the cellular level."

@Alan_Couzens Agree with you Alan. It is not a matter if we directly measure VO2max via metabolic card or we estimate it via end stage achieved in the test. CRF is associated with morbidity and mortality, but it is only one factor of our physical and physiological functions relevant for health

This whole thing is quite odd. One MET = 3.5 ml/kg/min of VO2. In the strictest sense, a MET is a direct measure of VO2 If there is any "conflation" going on, it is in making the assumption that a given level of exercise intensity within a given CRF protocol corresponds with a fixed number of METs/fixed VO2. He is correct that the majority of these studies don't measure VO2, i.e. they run a VO2 protocol but don't have the subjects hooked up to a met-cart - for practical reasons. However, if they were hooked up to a met-cart, the VO2max would line up relatively well with the end workload. And, when VO2max doesn't line up with the end-stage workload on a test, it's only due to differences in economy between the subjects. E.g. someone has a better or worse running gait - hardly a longevity measure. The problem is not that VO2max is not a good measure of cardiorespiratory fitness. The problem is that the number on most people's watches is *not* their actual lab-measured VO2max!

@DerekGriffin86 I suggest you buy refurbished Technogym treadmill. Here is an option: wellnesspoint.it/en/refurbished…

Any good recommendations on a treadmill for home? With a wide belt and speed up to 22km/hr. Any ideas appreciated 👌

@tomgoom Are people with MTSS subjected to loads that we consider physiological? Yes, most of the time. So, why is that their shins cannot tolerate such loads? When we answer this question, we will move fwd. I have my hypothesis based on clinical experience, but no real evidence.

Really interesting editorial from Anderson et al. (2025) suggests MTSS may not be a Bone Stress Injury and should be renamed Load Induced Medial-leg Pain (LIMP). Do you agree? 🤔 🔗 jospt.org/doi/10.2519/jo…

@JamesThrot Thx for sharing your observations. I’ve read several recent papers that show very good effects of hyperbaric oxygen therapy in individuals with long-covid symptoms, most of which are neurological. HBOT has also been shown to improve brain perfusion. Your thoughts on that?

We may be witnessing the early social consequences of mass neurological decline; not decades from now, but already, in real time. The changes are small, but unmistakable. And they align with what we know about the brain and COVID. END

As a neurologist, I can’t ignore what I’ve been noticing, both professionally and socially. People are not the same as they were before the pandemic. The way they communicate, interact, and connect feels… different. I want to know if you’re feeling this too? 🧵

@thegarybrecka Maybe it would be helpful to check your sources of info. You can start with this one. pmc.ncbi.nlm.nih.gov/articles/PMC10…

Delay coffee 60–90 minutes. Why? - Cortisol naturally peaks after waking - Caffeine too early → crash later - Wait → cleaner energy, steadier focus

@sserranobmsk Hi Sergio, thx for sharing this link…do you have a pdf of the article as I do not have access to full text? If so and if you are willing to share it, my e-mail is gogymarky@hotmail.com Thx

Ultrasound of Groin Pain in the Athlete doi: 10.1055/s-0044-1790525. This article focuses on the sonographic evaluation of groin pain in athletes. Groin pain is a common and debilitating condition with various etiologies affecting multiple anatomical structures (adductors, iliopsoas, inguinal ring, pubic symphysis, hip joint). While MRI is considered the gold standard, ultrasound (US) offers a valuable, cost-effective alternative, especially for identifying muscle injuries, inguinal disruptions, and hernias. The authors present a systematic US protocol ("Bordeaux Protocol"), emphasizing a detailed understanding of regional anatomy and potential imaging pitfalls. The protocol systematically assesses key structures, including the hip joint, iliopsoas, rectus femoris, adductors, pubic symphysis, and inguinal rings. The US examination should be performed bilaterally and dynamically, using Valsalva maneuvers where appropriate. The review describes the sonographic appearance of normal and pathologic findings in each region. Specific US features are detailed for conditions such as labral tears, iliopsoas strains, rectus femoris injuries, and inguinal disruptions. The authors stress the importance of a combined clinical and imaging approach, recognizing that US findings should be interpreted in conjunction with clinical presentation and other imaging modalities (MRI) when necessary, particularly for complex cases. They also advocate for the use of more specific terminology to avoid ambiguity.

@camtudor Thx a lot

@gogymark Hi Goran, here's a good overview. pmc.ncbi.nlm.nih.gov/articles/PMC81…

Many assume an ACL graft is fully "healed" at 6 months because they see an athlete return to sport. In reality, the graft is still maturing and can take up to 2 years to regain full strength. Why does it matter? A quick 🧵 on graft healing and implications for rehab. 👇1/7

@zanehkoch Hi Zane, would really appreciate if you could share a pdf of your paper. My e-mail is gogymarky@hotmail.com Thx!

Thanks to all involved! The paper can be found here (nature.com/articles/s4358…). DM me if you don't have access and want a pdf :)

WHY DOES THE EPIGENETIC CLOCK TICK? While money has been poured into developing therapies to reverse the epigenetic clock (@altos_labs 🤑), why the epigenome changes with age at all is unclear. In @NatureAging today, we suggest a potential driver: somatic mutations.

@BlueSpotScience @LizReisman @bluebirdi Congrats! Any chance to share the pdf version of that paper? My e-mail is gmarkov@kif.hr Thx!

Our latest review, led by @LizReisman & @bluebirdi has just been published in Critical Reviews in Biochemistry and Molecular Biology: bit.ly/3MVLZBb “Exercise Training and Changes in Skeletal Muscle Mitochondrial Proteins: from blots to ‘omics.”

@andrew_flatt Hi Andrew, do you have pdf of that article as I do not have access to this Journal via our institution? Thx

Sympathetic activity increases with age, partly due to ↓ adrenoreceptor sensitivity, & promotes CVD. Diet (kcal restriction, antioxidants) & aerobic exercise identified as key lifestyle interventions to restore age-related adrenergic dysfunction. sciencedirect.com/science/articl…

@meelonmuskusa 56

@compandalt At this area (not necessarily this point) you may have the compression of the tibial nerve by soft tissue behind the knee. So I would not say that there is no possibility of having a true effect needling this area on LBP. Note: I have stopped doing acupuncuture / DN in practice.

This is a perfect example of why #acupuncture is such a silly "treatment". There is no possible way that sticking needles behind the knee could have any impact on back pain.

@mkaeberlein Agree 100%

People should realize conflict of interest goes way beyond direct financial interest. In academic research, people's grants, tenure, careers, and celebrity are all tied up in selling and amplifying their own work and models, often at the expense of scientific rigor and truth.

@sally_science1 Muscle carnosine content as a method for estimation of muscle fiber composition ncbi.nlm.nih.gov/pmc/articles/P…

"Sally, your last tweet on muscle fiber types was interesting. How can I know my own muscle fiber type (% Fast Twitch vs Slow Twitch)? Thanks!" 👇1/17

@KThorborg Most of lengthening/negative work in this exercise is done by connective tissue - we have at least 3 studies confirming this.

This statement is completely wrong - and pulled out of the ….rse. Illustrates the challenge for athletes that needs to navigate through all this invented expertism 😒

@tomgoom Don’t forget saphenous nerve entrapment at knee and ankle levels

Anterior knee pain differential diagnosis

@stevemagness Great description of confidence!

Confidence isn't about pretending to be someone you're not. It's about being comfortable in your own skin, and trusting in your abilities to overcome challenges and succeed.

@RodWhiteley @KangaTech_ @VALDPerformance @aserner @KThorborg Check muscleboard.eu; feel free to contact me if interested

Physios working in football codes: for routine clinical testing and daily use what's your preference & experience with kangatech.com vs valdperformance.com/forceframe/ ? Help us decide what platform to go with