
@OpenAI Are the benchmarks run with the Life Sciences plugin enabled? And does the plugin materially change results e.g., does the GPT-5.5 delta to GPT-Rosalind meaningfully narrow with the plugin? Maybe @ChrisHayduk you might know?
Derek Croote
540 posts

@DerekCroote
Co-founder & CTO of clinical-stage antibody therapeutics co @IgGenix | Following trials with @trialinference | Previously @Stanford bioengineering PhD

@OpenAI Are the benchmarks run with the Life Sciences plugin enabled? And does the plugin materially change results e.g., does the GPT-5.5 delta to GPT-Rosalind meaningfully narrow with the plugin? Maybe @ChrisHayduk you might know?


We’re bringing new capabilities to GPT-Rosalind, a model series purpose-built for life sciences research at enterprise scale. It brings GPT-5.5’s agentic coding and tool use together with stronger intelligence for drug discovery, analysis, design, and experimental workflows. openai.com/index/introduc…










The year is 2026 and not a single brand on amazon contains an English word. New companies are spawned by the blind smash of a fist on the z x w q side of the keyboard. Vowels are banned. Each product has 2.5 million 5 star reviews. They're all written by AI. There are so many we need AI summaries. The summary is never helpful. The product images are AI too. Buy it Now happens automatically if you stare at an item too long. Nothing is what you want. Doesn't matter. Commerce enlightenment has been achieved.

Because of all the refusals (via API and separately in chat) I get significantly lower performance on my biotech benchmark that covers antibody therapeutics, tox, clinical dev, cell surface receptors, food allergens, and biological sequences.







