Mitrix Bio
12.4K posts
Mitrix Bio
@PathfinderEq
Bioreactor-grown mitochondrial transplant therapy for chronic disease and aging.
Tham gia Kasım 2012
349 Đang theo dõi5.1K Người theo dõi
I do include mitochondria as part of the overall aging as meta-disease with cellular senescence as causal nexus framework. Please see here!
zenodo.org/records/188736…
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In Vivo Ep 34: @bryan_johnson has done a lot to bring attention to biological immortality, but scientists like @abcsoka have been working for decades to understand the roots of aging. Does the accelerated aging disease Progeria hold the key?
youtu.be/PWJbc3IrrSg
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@InVivoPodOnX @bryan_johnson @abcsoka May we suggest...check out Dr. John Cramer, 91 year old emeritus physicist, currently undergoing the first-ever large-scale mito transplants. youtu.be/7yg2c0mwrtw?si…
His book on the topic: amazon.com/How-Live-Much-…
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@PathfinderEq @bryan_johnson @abcsoka 100% mitochondria are involved, will be covering it in an upcoming episode :)
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@radbackwards Livermore used to have a real old-fashioned downtown, with the old donut shop and Lourde's homemade ice cream.
That is the sugar-buzz force field drawing me in.
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Sauna data interesting. Need a study that actually measures BDNF etc and clinical outcomes to really prove. But I am doing it. Low risk. The evidence for cold afterwards is weak
Karl Mehta@karlmehta
We have proof that HEAT STRESS can reverse the brain's natural decline after 30. A 20-year Finnish study found that one 20-minute habit activates BDNF, the "neurogenesis protein" that grows new brain cells, strengthens memory, and cut dementia risk by 66%. Here's the breakdown:
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Jake DeWitte called me with an idea that most people thought was crazy. He wanted to build small fission nuclear power plants. For more than 40 years, the mantra “no nukes” permeated the zeitgeist, and half the people protesting were protesting nuclear war.
Jake said he could build a portable nuclear power plant.
That could power a small city, be placed anywhere, and even transported.
My nuclear physicist friend told me the timeline: "Five years to design. Five years for approval. Five more to build"
15 years. Minimum.
I invested anyway. I had faith in Jake that if anyone could get a nuclear power plant built in the US, Jake could.
Jake had the energy and drive to actually pull this off. Most entrepreneurs would've given up after hearing that timeline. He doubled down.
Fast forward to today: Oklo became the first nuclear power company to get US approval in 40 years.
Jake took the company public via SPAC.
The Aurora reactor (their flagship model) is a 1.5-megawatt beast that runs for years without refueling. Uses spent nuclear fuel. Cuts waste and environmental impact. Perfect for remote areas and small grids. Oklo today is worth more than $10 billion.
Nuclear energy can reduce the carbon emissions damaging Earth. Oklo will be the company that makes it happen.
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The list omits key longevity scientists:
Alex Zhavoronkov
Anne Brunet
Haim Cohen
Brian Kennedy
Cynthia Kenyon
Dudley Lamming
Irina Conboy
Joe Baur
Juan Carlos Belmonte
Steve Horvath
Vadim Gladyshev
Vera Gorbunova + more
tinyurl.com/3xbh9pav
Longevity Now@Longevity_Now_
Top 10 Most Influential People in Longevity 1. David Sinclair 2. Bryan Johnson 3. Peter Attia 4. Sam Altman 5. George Church 6. Matt Kaeberlein 7. Aubrey de Grey 8. Brian Kennedy 9. Ray Kurzweil 10. Peter Diamandis
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@ChrisMasterjohn Congratulations. You've found the last, hidden key to mitochondrial dysfunction.
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Or maybe you just need to cuddle for longevity.
This can likely help reverse mitochondiral dysfunction by decreasing the wasteful loss of mid-infrared light produced during metabolism and causing it to be reabsorbed by the other person.
Dr. Rhonda Patrick@foundmyfitness
Oxytocin is more than the “cuddle hormone.” It may be a key regulator of aging and longevity. We've long known about oxytocin's role in translating social experiences into physiological health and stress resilience. New research identifies the biological mechanism. Oxytocin levels decline with age, leading to epigenetic remodeling, mitochondrial dysfunction, and chronic inflammation. Restoring oxytocin levels reverses these changes. This points to a profound idea: cultivating strong social ties throughout adulthood can mitigate this loss of oxytocin signaling and promote robust health and resilience against stress and disease. As sterile-sounding as it might seem, it's a strong argument to think about intimate bonds and social interactions as pro-longevity interventions. They're not optional.
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Palantir CTO @ssankar says former casino workers in Sparks, Nevada, have reskilled into advanced manufacturing jobs at Panasonic Energy, supplying the Tesla Gigafactory:
“It used to take three years of apprenticeship to learn how to be a battery technician. With AI, it now takes three months.”
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@RyanBethencourt @auryn_macmillan Europa is like a candy box just waiting to be opened.
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@auryn_macmillan I'm convinced that our solar system is filled with life and it'll be so obvious in retrospect once start really exploring across it.
I'd even bet Venus, Mars and many of the Moons like Europa are filled with life once we can get close enough to examine them!
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This is pretty wild. Presumably implies that any planet with a habitable zone similar to earth that has been impacted by similar asteroids could develop life.
There is perhaps much more life out there than we expected?
Curiosity@CuriosityonX
BREAKING🚨: ALL FIVE types of nucleic acid bases, the building blocks of LIFE 'DNA and RNA', have been found in samples collected from asteroid Ryugu
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Dune
Star Wars
Lord of The Rings
I cannot wait to rewatch these with my son
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Welcome! There is no place else in the world like this, if you just want to wallow in new technologies morning noon and night. Or study them, or talk about them over beer with a bunch of other obsessive techies.
Then walk in the redwoods and think about where the world is going with all this.
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I just cannot believe I get to be in Silicon Valley for all of this
Seeing computers wake up & help humans feels like the plot of a magical science fiction movie
Jaw dropping progress everywhere
So much stuff to be done
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@FutureJurvetson BALLS - top notch fun, like Burning Man but without the other 39,900 people
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The world’s largest launch events are in the Black Rock Desert after Burning Man. I have gone with my kids every year for 20 years. These 2 are:
1) My photos from BALLS, for launches that are illegal in California: flickr.com/photos/jurvets…
2) One of mine: youtu.be/MkmK7giUej0?si…
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Steve Jurvetson@FutureJurvetson
For Saint Patrick’s Day, one of my favorite rocket launch photos… Black Rock Desert, NV The green glow comes from barium chloride mixed into the AP propellant. I planned the camera location in advance to bisect the moonrise, and then my rocket did something very unusual.
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Great to be back from Nepal!
In this week's first Substack article, we discuss a recent paper written with Chris Kempes on the role of energy in health and disease.
The key difference between life and death is not the physical stuff of life. It's the flow of energy.
We propose that thinking about health and disease processes energetically can unlock a meaningful transition to the next stage of evolution for biomedicine.
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Mitrix Bio đã retweet
Alberto Magrì is one of the most beloved and famous Italian 🇮🇹 pastry influencers
In this spectacular video, he makes his famous lemon Neapolitan sfogliatelle 🍋
His technique is truly one of a kind
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This issue is about to become a non-issue.
15 states have now passed the "Right to Try 2.0" legislation that explicitly allows such drugs to be administered by doctors to patients, WITHOUT federal approval.
Also a national version of this law will be going to Congress/Pres. Trump in mid-2026.
These laws are being passed because there are now potentially tens of thousands of new drugs being created every year. Our biotech industry is going into hyperdrive. And the FDA, at best, approves 50 per year.
It doesn't matter how many FDA staffers you hire, it doesn't matter how much you computerize or modernize. It is mathematically impossible for a single Federal agency, no matter how well-intentioned, to regulate 10s of thousands of individualized genetic drugs.
So the State governments are taking over the job.
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Am I interpreting this Tweet correctly - individualized n=1 mRNA cancer vaccines are trivial to make but are never used in people because you can't do an RCT with one person? This seems like a gigantic regulatory failure.
Patrick Heizer@PatrickHeizer
Sorry to be the downer because this is an impressive story in some senses. But it is ~trivially easy to make a single mRNA vaccine. It's not hard. I cure mice of various cancers with various therapeutics all the time. I've made mice lose more weight in a month than tirzepatide does in a year. What is hard and expensive is proving its BOTH safe AND effective **in a randomized and controlled study in humans** while ALSO manufacturing it at clinical scale and grade. I am happy for this man and his dog. It is impressive. But y'all are overhyping it.
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@PathfinderEq @SocraticScribe Different kind of fusion, this version is much much easier.
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The Sunbird Fusion Rocket from Pulsar Fusion echoes ideas long explored by propulsion pioneer Paul Czysz, using advanced propulsion to transform deep-space travel. Fusion rockets could cut Mars trips to weeks and open the outer solar system.
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@ItzSuds If you aren't obsessed with creating whatever it is you are creating, don't become a founder.
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Ppl laugh when I say there’s no job mentally harder than being a founder
Externally it looks glam but it’s a highly levered lottery ticket that mostly just leaves you broke & you’re getting punched in the face 9/10 days
TK is the definition of resilience, I look up to him a lot
travis kalanick@travisk
Atoms. atoms.co/vision
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The value of Nevada property just went up.
Autism Capital 🧩@AutismCapital
🚨BREAKING: Washington State passes their first ever income tax. Incomes over $1M/year will be taxed at 9.9%. Married couples share A SINGLE $1M exemption, so if combined incomes are more than $1M, you're getting taxed. This will obviously eventually extend beyond millionaires. What comes for others, will eventually come for you! RIP Washington state!
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