
Philippe Rola
23K posts

Philippe Rola
@ThinkingCC
#zentensivist, EMCrit Teammate, Proud daddy and husband. BJJ🟪. ICU Santa Cabrini Hospital.







🫁 We thought “lung-protective ventilation” was enough. It isn’t. ⚠️ The problem Low tidal volume (4-8 ml/kg PBW) changed outcomes. But here’s the issue: 👉 ARDS is not one lung 👉 It’s a patchwork of different lungs Collapsed units Overdistended areas Normal regions 👉 Same ventilator setting = completely different stress per region 🧠 The key concept: “Baby lung” You’re not ventilating 5 liters. You’re ventilating: 👉 maybe 1-2 liters of functional lung So even “safe” tidal volumes can become: 🔥 Overdistension in disguise 💥 What actually causes VILI? Not just pressure. Not just volume. 👉 It’s uneven distribution of stress and strain Four classic mechanisms: Barotrauma Volutrauma Atelectrauma Biotrauma But now we understand: 👉 Mechanical power = the real integrator ⚡ The new paradigm Ventilation is not about settings...It’s about physiology. 🔬 What should we actually target? 💡 1. Driving pressure (ΔP) 👉 Best bedside surrogate of lung stress 👉 Aim <15 (ideally <10) 💡 2. Mechanical power 👉 Energy delivered to the lung 👉 High MP = higher mortality 💡 3. Recruitability 👉 Does PEEP open lung or overdistend it? 💡 4. Patient effort 👉 Too much → P-SILI 👉 Too little → diaphragm atrophy 💡 5. Regional ventilation (not global) 👉 EIT, LUS, esophageal pressure = game changers 🫀 The part we ignore too often Ventilation is NOT just lungs. 👉 It affects: Right ventricle Cardiac output Kidney perfusion Brain function 👉 VILI = multi-organ disease 🤖 The future is already here Closed-loop ventilation AI-driven adjustments Digital twins of the lung 👉 From reactive → predictive ventilation 🚨 Take-home message > There is no “safe ventilator setting” There is only a setting that is safe for THAT patient, at THAT moment 🎯 Final thought We need to move from: ❌ Protocol-driven ventilation To ✅ Physiology-guided precision ventilation 📚 Reference Merola, R., Battaglini, D., Schultz, M. J., & Rocco, P. R. M. (2026). Physiology-guided personalized mechanical ventilation to prevent ventilator-induced lung injury. Frontiers in Medicine, 13, 1764151. doi.org/10.3389/fmed.2…


ICU - Board Review Qs: 60 yo pt admitted to the ICU because of inferior STEMI. Emergency cath: 100% proximal RCA occlusion treated successfully with stenting One hour post-PCI: dyspnea/anxiety - BP: 94/70, HR: 60/min (sinus). Phys exam: JVD (+), clear lungs, cool extremities

What is the most reasonable immediate next step?























