Simon

This is Dr. László Boros. A Hungarian medical doctor, retired professor at UCLA, author of 100+ scientific papers & one of the world's leading deuterium researchers. His message? Every chronic disease begins when the body loses control of deuterium. Here is his framework: 🧵

#ClickHouse #DataAiSummit

@bryan_johnson @TaraBull hahaha

@TaraBull they're my brothers

Who are these guys?

This is INSANE! Get off OZEMPIC ASAP!

@HarryCantein @bryan_johnson ERW water

@bryan_johnson Will you be releasing anything to help reduce elevated LDL?

I just launched a longevity Rx platform. Prescriptions I personally use are there. v1 is live now. Includes access to: + Tadalafil (Cialis) + Metformin + Oral Minoxidil + Tretinoin + Estradiol + Acarbose We’re working with licensed doctors and pharmacies to make these medications accessible. Lots more in v2 coming next week.

MİLYAR DOLARLIK ROBOTİK ŞİRKETLERİNİN 50 YILLIK MOTOR TAKINTISI AZ ÖNCE ÇÖPE ATILDI. Mit araştırmacıları insan kasını birebir kopyalamış. Ama o bildiğiniz ağır metal dişliler, karmaşık hidrolikler veya binlerce dolarlık servo motorlarla değil. Sadece elektrik yüklü bir sıvı ve minik bir pompayla. Sistem dümdüz senin kolun gibi çalışıyor. Pompa içeriye elektrik veriyor, iyonlaşan sıvı hareket ediyor ve lifler kasılıp gevşiyor. Kolunu büktüğündeki kasılmanın aynısı. SIFIR MOTOR. SIFIR HARİCİ DONANIM. VE TAMAMEN SESSİZ. Herkes bilim kurgu geyiği yapıyor. Oysa burada koca bir endüstrinin maliyet yapısının nasıl tabana vurduğunu izliyorsunuz. Yıllardır donanım üretmek demek, arıza yapan metal yığınlarıyla ve sürtünmeyle boğuşmak demekti. Şimdi olay sadece basit bir sıvının iyonlarla yönlendirilmesine döndü. Bu lifleri gerçek kas gibi birbirine sardıkça gücü katlanarak artıyor. Yani performansı artırmak için daha büyük ve pahalı bir mekanik motora ihtiyacın yok. Sadece o bağlama birkaç tel daha ekliyorsun. Kuvvet doğrudan ölçekleniyor. DONANIM ARTIK YAZILIM GİBİ UCUZ VE MALİYETSİZ BİR ŞEKİLDE ÖLÇEKLENİYOR. Parça üreticilerinin fişi çekildi. Üretim bandındaki ağır sanayi tezgahlarından bahsetmiyoruz artık. Etrafında dolaştığını bile duymayacağın, seninle aynı organik esnekliğe sahip maliyetsiz sistemler geliyor. Mekanik devri kapandı. Yeni oyuna uyanın.

@ritwikpavan HR and skin temp, or can it measure anything else as well?

NEW: This wearable wants to be a calendar for your body. Luna Band pairs with LifeOS to plan your day around your body, goals, recovery, and energy. • creates an hour-by-hour plan based on your real-time health signals • uses haptic alerts to tell you when to eat, train, rest, or wind down • voice-first logging makes it easier to capture food, habits, and context • LifeOS connects biometrics, blood markers, medical context, and food habits • micro-apps cover stress, nutrition, training, supplements, productivity, and circadian rhythm Most wearables track your body. Luna is trying to help you plan around it.

@drewfallon12 😂

FEEL PEPTIDES RAISES $3M SEED Feel Peptides closed a $3M seed round led by Sugar Capital. Most of the consumer peptide market still runs through compounding pharmacies, gray market online sellers, and wellness clinics with minimal transparency on sourcing or purity. Feel is the brand layer when the FDA clarifies its restrictions on popular peptides, a regulatory reset that's been building since 2023 and has more political tailwind now. Sugar Capital backed Grüns, sold to Unilever for $1.2B less than three years after launch. Another peptide startup Protocole just raised a $6M seed led by Rare Capital last month.

@BillAckman Tell him to incorporate our bionic hydrogen fountain, so you guys can stay properly hydrated. pythownater.com

My physical therapist opened a superb gym in a beautiful and intimate space in a great location at 32 East 57th Street next to Atria. The concept integrates physical therapy with weight training, cardio, sauna, steam, cold plunge, sensory deprivation, VO2 max and all the other testing you need to determine your base line fitness and monitor your progress thereafter as well as much more.
 Vosk has the best equipment I have ever seen in any gym and extremely experienced trainers and physical therapists. It is a great place for serious athletes and those interested in longevity or just getting in great shape.
 While it is a high end gym, the price is fair when you consider the cost of the 96 training and/or physical therapy sessions included in your annual membership. The integration of physical therapy and training yields much better and safer outcomes. I have also found my training consistency is much greater since I prepaid for the sessions. If you want to learn more, go to Voskcenter.com or email Vitaly who founded Vosk at hello@voskcenter.com. The first 40 members who mention this @X post will have their initiation fees waived. Membership is limited to ensure a great experience.

The hottest new programming language is English

@gregisenberg that two phone thing was like an aha moment lol

I just got back from SF and I FEEL INSPIRED. I spent 5 days with frontier AI model teams, AI startup founders, and 3 billionaires. My takeaways: 1. I had lunch with 3 billionaires. All of them are buying SaaS companies and rebuilding them agent-first. They were deeply inspired by Bending Spoons and Ryan Cohen's eBay deal. Buy the company, cut the headcount, rebuild the tech, add agents, add features, make more valuable experience, raise prices. 2. The frontier model companies are hungry for usage data from the field. They can see API calls and token counts. They can't see the actual workflows. If you're deep in a niche using these models in ways the model companies haven't seen, that understanding is incredibly valuable. Usage intelligence is the new alpha. 3. Consumer AI is massively underbuilt. Every billboard in SF is either B2B inference infrastructure or vertical agent companies. The entire city is optimized for enterprise. Meanwhile you have companies like Cal AI doing $50M ARR in 18 months as a consumer app. I met with a cool few teams doing consumer AI (@paulscherer / @ekuyda) 4. MCP came up in literally every conversation. The companies exposing their product as MCP endpoints are getting pulled into deals they never pitched for. The ones that aren't are becoming invisible to agents. This is the new SEO. If agents can't find you, you don't exist. Building products for agents is the new zeitgeist in general. 5. Not uncommon for hot seed rounds to be $25-50 million valuations. I saw a Series A at $450 million 6. If I had a dollar every time someone mentioned "forward-deployed engineer" this trip I could have funded a seed round. It's the hottest role in SF right now. The person who sits between the agent and the customer, making sure everything actually works. 7. The mood around open source shifted. A year ago it felt like open source was chasing the frontier models. Now founders are telling me Gemma and DeepSeek are good enough for 80% of what they need at a fraction of the cost. The "which model do you use" conversation is being replaced by "which model for which task." Model loyalty kinda feels dead. 8. Voice agents came up more than I expected. Multiple founders told me voice is the interface for the next billion users. The billion people who will never type a prompt will absolutely talk to one. 9. The Obsidian community in SF is weirdly intense. Multiple founders showed me their vaults unprompted. Like showing someone your home gym. It's a flex now. The quality of your knowledge base (second brain?) is becoming a status symbol among builders. 10. Maybe it was just the people I met but the age of the founders is shifting. I met more founders over 40 this trip than any trip before and more founders under age 21 than ever before. Founders getting older and younger at the same time. 11. I spoke to a lot of fast-growing startups, VCs and frontier models who are hiring content creators right now. 12. The restaurant scene in SF is actually better than it's been in years. Founders are going out more. Alcohol is out, not surprisingly. 13. SF doesn't feel like the only place anymore. We all have access to the same frontier models. We all read the same X feed. A founder in NYC or Lagos is calling the same APIs as a founder in SoMa. So in the past it felt like SF was always lightyears ahead, doesn't feel that way anymore. It's okay not to live in SF and have BIG DREAMS. 14. The coworking spaces in SF are half empty but the coffee shops are packed. People want to be around people. I had a few startup ideas here.... 15. Walking around the Mission I noticed something: the street-level businesses, the taquerias, the barbershops, the laundromats, none of them use any AI at all. 16. I heard the phrase "agent debt" for the first time. Like technical debt but for agents. When you hack together an agent workflow fast and never clean it up, the system prompts conflict, the memory gets polluted, the tools overlap. 6 months later the agent is doing weird things and nobody knows why lol. 17. Met a few people who carry two phones now. One for personal. One that's basically an agent terminal running Telegram or iMessage connections to their agent fleet. It's always amazing to get that dose of inspiration in SF. I FEEL INSPIRED. But I'm so happy to be back home, locked in and building. We're 12-18 months into a shift that will take 15 years to play out. The urgency in every conversation was real. What an incredible time to be building.

@JoumanaElomar focus on product and customer experience, not branding lol

@SethSHowes Human genome is subordinate to human water

I just sequenced a human genome to 30× coverage entirely at home. As far as I know, this is the first time this has been done. I didn’t step foot in a lab once. Every step - from saliva collection, to running the sequencer - took place in a single room with a dining table + kitchenette. Six weeks ago, I had never done wet lab biology before. I used an Oxford Nanopore P2 Solo - the only commercially available sequencing device portable enough to do 30x human genome sequencing at home. Biggest takeaway - I could build something that combined software, hardware, and molecular biology far faster than I thought was possible. I can name >100 specific instances where AI helped me solve a technical problem that would previously have blocked me because I lacked access to a domain expert. For example: how do I save my sequencing run when my DNA extraction yield is 4x lower than I need it to be, and I have this limited set of reagents to hand? To make this work, I had to navigate multiple disciplines: - writing software to monitor sequencing runs and orchestrate remote GPU infra for basecalling - learning + executing 5 hour long molecular biology protocols - building a hardware device to quantify DNA concentration Apologies for the hyperbole, but I feel super lucky to be living in 2026. A few weeks ago I decided to sequence a human genome to 30x at home. Then I actually did it. And I did it really quickly.

@immad Thanks

Over the years, I have tried to share learnings from my startups and seed investing. Decided to combine my startup tweets+tweetstorms into a tweethurricane. Here are my learnings + advice, from pitching investors to getting through the journey:

@alluringmedia @Victori83525871 @PeterHadIt not just him

@Victori83525871 @PeterHadIt Except Elon Musk is a drug addict. Thanks

Take it from me, as someone who did COPIOUS amounts of Ketamine in my 20s, that is not all he is on.

@bryan_johnson @eightsleep Lets do one with a clinical grade hydrogen bottle / ours

My EightSleep mattress has been through a lot with me: + 15,070 hours of sleep + 8 months of perfect sleep + Witnessed Kate’s 1% + Nightly 3.5 hours of NTE We're now partnering with companies I trust and EightSleep was the first brand I chose to give the Blueprint approval. I'm proud they're our first partner and that our customers get a discount. I've come to love this bed so much that travel hurts. A hotel mattress with no temperature control is a pinprick reminder of how much temperature drives sleep quality.

@hdubugras Would you be interested in a 50-piece AI high-agency hydrogen hydration pilot for Brex? We bank with Brex :)

Hot take: now with LLMs, .NET is actually quite good. The verbosity was a big problem in the past but now with LLMs it's a feature.

@TimurNegru where did you get that info?

A 243-acre private Greek island is going to auction in November for €247k ($287k). Three years ago it was listed at €8 million. The island is Makri, in the Echinades archipelago, roughly 30 km east of Kefalonia. There are three abandoned buildings on it: a stone house, a water cistern, and a chapel. €1,000 per acre for a Mediterranean island sounds absurd and it is, but the main reason it's so cheap is that it's classified as private forest and sits inside Natura 2000, the EU's protected habitat network. So you can't build a resort on it. You can do agriculture and put up minimal structures, and that's about it. Everyone's debating what people will do once AI and robots handle most of the work and places like this start to look like an answer. It's a Mediterranean island where you can live off-grid, grow food, raise animals, and have a real physical life. Would you go for it?

@enhanced_games Lets enhance some more with H2 infused hydration for all enhanced athletes. We would like you to consider us to be enhanced's choice for bio-optimized H2 water.

We're Enhanced. Trading legacy restrictions for rigorous medical governance and elite clinical protocols. Welcome to the Enhanced Games - the first international sporting event at the intersection of elite athletics and modern medical science.

@Adityalch Don’t do it again, you don’t understand what it does to your health down the road.

Full 6-month results: Starting: 169.8 lbs, 21% BF, 128 lbs lean mass. Ending: 179.3 lbs, 17.3% BF, 142 lbs lean mass. Net: +14 lbs lean mass, -4.5 lbs fat. Lost 4.2 lbs muscle on the cut, gained 18.2 on the bulk. Would I do it again? Absofuckinglutely. I'm particularly excited about replicating Interval 4 - high mass gain with steady fat loss month over month. That's the beauty of Test.

I ran 300-500mg Testosterone per week for 6 months at 26. We tracked every biomarker to see how it affected my body. Monthly DEXA, bloodwork, every workout and calorie tracked through Prana. Here's what we found when we ran the data through our system: