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Stop scrolling. This might be one of the most important thing happening on Hyperliquid right now and almost nobody is talking about it. What you're looking at is the first independent client achieving block hash parity with Hyperliquid validators. For non-technical people: Hyperliquid hasn't open-sourced its node client. The code that runs the network is a compiled binary, a black box. @androolloyd took that black box, 87MB of machine code with no documentation, and reverse-engineered it using AI and Ghidra. He decoded every formula, every structure, every protocol. Then he built his own client from scratch that produces the exact same results as the official validators. 3/3 match. For technical people: full verification chain cracked. keccak256 on raw msgpack for block response hashes. blake3 keyed for consensus transactions. LtHash16 with SSE2 paddw across 14 accumulators (11 L1 + 3 EVM) finalized with SHA-256 for state hashing. All reproduced independently from a stripped ELF binary with zero source code. What this means: anyone can now verify the Hyperliquid chain independently without trusting the official binary. This is the foundation for a truly decentralized validator set where operators don't depend on one codebase. Independent implementations make the network stronger, more resilient, and harder to compromise. The team didn't open-source the client. So someone reverse-engineered it and built one anyway. That's the kind of ecosystem Hyperliquid has. I'll be covering this work in depth over the coming days to make sure everyone understands the magnitude of what's being built here. Legendary work happening in real time. Hyperliquid.

1) Update the hero section with a simpler hook 2) Brought FDA trial prediction markets to the home page 3) Cleaned up the navbar and added a footer with some of the extra stuff. Might delete stuff there soon but better than being in navbar. Even more coming to endpointarena.com soon!

1/n Setidegrasib the first-in-human, first-in-class, KRAS G12D-targeted protein degrader #TPD Our KRAS G12D degrader study is now published in the New England Journal of Medicine @NEJM nejm.org/doi/full/10.10… A new way to target KRAS G12D - one of the most common oncogenic drivers across cancers.

@quasimatt MSP FnM

Working from Madison Square Park in Flatiron/NoMad today. Nothing has ever felt so right.

NEW: CFTC CHIEF SELIG TO CLEAR PATH FOR U.S. PERPETUAL FUTURES IN COMING WEEKS - COINDESK SOURCE: coindesk.com/policy/2026/03…

In a phase 1 study of the oral p53 reactivator rezatapopt in heavily pretreated patients with TP53 Y220C–mutated solid tumors, the most common adverse events were nausea and vomiting, and the overall response was 20%. Full PYNNACLE study results: nej.md/3OIQC5P Science behind the Study: Restoring Function to a Variant of p53 in Solid Tumors nej.md/3N0pQW8

Mom theyre literally transducing metabolic fungal genes into immune cells to kill cancer cell.com/cell/fulltext/…

@berkozdemir Congrats Berk!

today is my 1st week anniversary on being a non-smoker. i finally feel free from this parasite addiction, and i don't intend to relapse ever again. and i aim to utilize the self confidence and respect i am building from this to kill other addictions i have.

Today we're releasing PaperQA3, our latest literature search agent, which has the best multimodal capabilities among deep research agents today by a large margin. Edison Literature and Kosmos can now read figures and tables from over 150M full-text research papers, as well as patents, clinical trials, and more. Additionally, we’ve updated the underlying algorithm of our literature agent (which is open source at github.com/Future-House/p…) to improve its ability to answer more complex questions. The result of these improvements show Edison Literature as one of the strongest deep research agents across benchmarks, beating out current-day frontier deep research agents. The PaperQA3-backed version of Edison Literature is available today on our platform and API as literature-20260216, as is Edison Literature High (literature-20260216-high), a high-effort variant for best performance.

Today we share a technical report demonstrating how our drug design engine achieves a step-change in accuracy for predicting biomolecular structures, more than doubling the performance of AlphaFold 3 on key benchmarks and unlocking rational drug design even for examples it has never seen before. Head to the comments to read our blog.

Bro is Nobel Prize maxxing

did anyone congratulate @saylor today?

Today we’re launching Phylo, a research lab studying agentic biology, backed by a $13.5M seed round co-led by @a16z and @MenloVentures / Anthology Fund @AnthropicAI. We’re also introducing a research preview of Biomni Lab, the first Integrated Biology Environment (IBE), where we’re imagining a new way biologists work. Biomni Lab uses agents to orchestrate hundreds of biological databases, software tools, molecular AI models, expert workflows, and even external research services in one workspace, supporting research end-to-end from question to experiment to result. Agents handle the mechanics, while you define the question, then review, steer, and decide. Scientists end up spending more time on science: asking questions, understanding mechanisms, and eliminating diseases. Phylo (@phylo_bio) is a spin-out of @ProjectBiomni, where we will maintain the open-source community and push open-science research. I’m grateful to continue building with my co-founders @YuanhaoQ @jure @lecong and the dream founding team @serena2z @TianweiShe @huangzixin20151 @gm2123 @margaretwhua @malayhgandhi. We’re also fortunate to be advised by leading scientists @zhangf, Carolyn Bertozzi, and @fabian_theis, and supported by an amazing group of investors including @JorgeCondeBio @zakdoric Matt Kraning @ZettaVentures @dreidco @conviction @saranormous @svangel @valkyrie_vc and others. Biomni Lab is available for free today: biomni.phylo.bio Learn more in our launch post: phylo.bio/blog/company-f… We are also hosting launch events - join us at South San Francisco: luma.com/n8k8qb0n Virtual: luma.com/l5ryjaij We’re also hiring! phylo.bio/careers

@diastemagan @PunksGan @cobie Bgan

@PunksGan @cobie Bgan

GAN GANG GONNA FLIP OG PUNKS WHEN SIR ?

@ddimes333 x.com/Nexuist/status… kinda risky now, no?

nothing gets the point across better than a good video/image

@whatdotcd Please send

I LOVE SOULSEEK. So I built a modern client and if you love soulseek and want to use it I'd love to share it with you. You can watch this video to get a quick feel but it's designed to be lightweight/simple and easy to browse users collections. That way you can find good new music and then buy that music and more on Bandcamp. If you'd like to use it just reply here and I'll dm you a link.

nice, someone put it on yt with a subtle little visualizer youtube.com/watch?v=IDzjT5…