Joshua C. Doloff

@HopkinsEngineer @ScienceTM Thanks for highlighting our work!

On @ScienceTM cover: For people with Type 1 diabetes, cell transplants could replace insulin injections... IF paired w/ immune-suppressing drugs. But a new “crystalline shield” from @DoloffLab may protect transplanted cells WITHOUT immune system shutdown. engineering.jhu.edu/news/the-new-c…

@JGreenGroup @HopkinsEngineer @JHUBME @JHTechVentures @HopkinsMedicine Congrats Jordan, and Green Grouo!

New #immunoengineering study on in vivo CAR #Tcells with #biodegradable #polymeric #nanoparticles useful for #autoimmune diseases and #cancer @JHUBME @JHTechVentures @HopkinsMedicine @HopkinsEngineer hopkinsmedicine.org/news/newsroom/…

@nguyenuconn Congrats Thanh!

Honored to be elected to the Connecticut Academy of Science and Engineering! ctcase.org/connecticut-ac…

@Jere_je_je @JohnsHopkins @JHUBME

Belated professional update 🔊 I’ve been promoted to Associate Professor with tenure at @JohnsHopkins @JHUBME. I’m incredibly thankful to my mentors over the past two decades, to my past and current collaborators (and friends!), and immensely proud of my students!

@Dan_A_Heller @mustafaoguler Nice! Congrats Dan!

On the cover of this month's issue of Nature Nanotechnology! Our nanosensor + AI-based liquid biopsy (blood test) for brain tumors that also enables the discovery of new biomarkers. nature.com/articles/s4156…

I think there is a need for a complete re-think for organoid modeling. As long as the architecture of organoids that you produce is not directly compared to a 3D map of the organ (say, fallopian tube) or disease to be modeled, it will be approximate Here: science.org/doi/full/10.11…

@RongFan8 @JHUBME Thanks Rong! Hope things are well with you too!

@JHUBME @DoloffLab Congratulations Josh!!! 👏👏👏

Researchers from the @DoloffLab have developed a crystalline ‘armor’ that protects insulin-producing transplants, offering a path to manage diabetes without daily needles or immunosuppressants. bme.jhu.edu/news-events/ne…

Thanks @YLeyfman for the shoutout and cool highlight/synopsis of our work! @JHUBME @TTECJHU @INBT_JHU @HopkinsEngineer @HopkinsMedicine @JohnsHopkins oncodaily.com/voices/yan-ley…

Many postbachs can’t get into grad schools this year because the number of offers dropped dramatically. Many postdocs can’t get jobs this year because faculty and industry recruitment dropped dramatically. How blind one should be not to see the impact on American science?! 🤦‍♂️

@MuyinatuBell @AcadofInventors Congrats Bisi!

I’m honored to be elected with this class of NAI senior members 🥰 Thanks to everyone in @AcadofInventors for the warm welcome so far! 🤗

@UMassDiabetes @UMassChan @BrimrOrg @NIH @BrehmLab @ProgMolMed @UMass_Medicine Nice photo @BrehmLab!

Four @UMassChan #diabetes #researchers are ranked among the Top NIH-funded faculty nationwide in Anatomy/Cell Biology, according to @BrimrOrg rankings. In today’s highly competitive funding climate @NIH support is a national benchmark for scientific excellence.

@JHUBME Thanks again to our collaborators, especially @The_Farah_Lab and Matt Bochenek, as well as @BreakthroughT1D for your continued support of our work!

Excited to see great colleagues and friends win major awards from @SFBiomaterials! @veiseho @JGreenGroup won the Clemson Awards for Basic and Applied Research, and my @pennbioeng office neighbor @ClaudiaLoebel won the Young Investigator Award! Link: biomaterials.org/publications/n…

Our new Nature study, lead by @yuexing identifies a brief early-life window when skin dendritic cells sense common allergens and trigger inflammation right in the skin without migrating to lymph nodes. We define this in-situ activation state as peripheral immune inducer (pii)DC, and show it emerges because of a still-maturing HPA axis and low systemic glucocorticoids. #Naiklab 👉Key takeaways: 1. Early-life immunity plays by different rules. During this window, innate responses to allergens in skin are heighted. 2. Hormones shape immunity in real time. Developmental neuroendocrine states profoundly tune how the immune system reacts, and can set the stage for inflammatory disease. Thanks our incredible collaborators @niroanandalab @EmmaGuttman @kamalkhanna @Teresalu @Amandalund and others. Our funders @NIAIDNews @NIH @DermalCell @SinaiImmunol @MSHSDerm nature.com/articles/s4158…

Federal funding for US biomedical research is moribund. Since October 1 2025, NIH is -80% in new grants and -70% in values (total dollars). Labs are closing down and researchers are leaving science. To what end?

Myeloid core of TB granulomas is partitioned into two distinct metabolic environments, one of which is hypoxic & associated with pathological immune cell states that subvert immunity to TB @NatImmunol @Stanford @NIAIDNews @MikeAngeloLab nature.com/articles/s4159…

Hyperactivation of sympathetic nerves fuels basophil infiltration in atopic dermatitis cell.com/immunity/fullt… @ImmunityCP 🇨🇳