Awesomics

Celebrating 10 years tweeting about the awesome power of post-genomic science and the medically useful insights gleaned from whole-{genome, exome, transcriptome, proteome, metabolome, microbiome, etc-ome} analysis🧬 Looking forward to what the next 10 yrs of #omics will bring...

Geneticist Mary-Claire King changed the way we think about hereditary cancer. We spoke with her about her career, research, and how she approaches science. buff.ly/nwsUeYu

“Exercise hormone irisin mediates neuroprotective effects of exercise in experimental autoimmune encephalomyelitis (EAE) mouse model of MS… reduces clinical symptoms & neuronal loss abrogated in mice lacking #Fndc5/irisin” #NeuroDegeneration #MS #AerobicExercise #inflammation

"So far @NIH awarded <50% of new grants it had handed out compared to prev 5yrs. NIMH issued ~33% of new grants. The agency may struggle to spend all its funds by 30 Sep (fiscal year). Any unspent $$ has to be returned to @USTreasury" nature.com/articles/d4158… #researchFunding

A foundation model of transcription across human cell types | Nature nature.com/articles/s4158…

@DattaScientist @scifri @NDTIMELab A new take on the term “spatial biology“: biomedical research taking place in outer space 🪐 #spatialOncology #spatialBiology #spatialOmics

🎙️🚀Check out my interview on the latest episode of @scifri, "The new frontier of cancer research is in space." So thrilled to talk about @NDTIMELab's work with host Ira Flatow and alongside field pioneer Catriona Jamieson. Listen to our conversation here: wnycstudios.org/podcasts/scien…

Does brain aging always mean vessel loss? 🧠We found a surprising hypervascularization, driving cognitive decline & blood-brain barrier damage in aging. 👇🧵biorxiv.org/content/10.648… Led by @MihailMuc

@Move_n_Groove_ Study: Enhanced Protein Translation Underlies Improved Metabolic & Physical Adaptations to Different Exercise Training Modes in Young & Old Humans (Robinson, 2017, OA) cell.com/cellmetabolism… "HIIT reversed many age-related diffs in the proteome" #mitochondria #aging #ageing

NSF announces $1.5B NSF X-Labs initiative to pursue generational breakthrough science efforts. NSF X-Labs will scale a new generation of transformative independent research organizations to advance breakthrough science outside of traditional institutions. nsf.gov/news/nsf-annou…

Today in @ScienceTM, we report the use of in vivo adenine base editing to correct a variant causing Dravet syndrome, a severe childhood epilepsy and neurodevelopmental disorder, substantially ameliorating disease symptoms and extending lifespan in an animal model. 1/13 drive.google.com/file/d/12rcxew…

Geneticist J. Craig Venter, best known for his role in sequencing the human genome, has died aged 79. He spoke to Nature in 2023 about AI, sequencing the ocean – and why he had no plans to stop working. go.nature.com/4tHEf9M

Today in @Nature, the @genophoria & Vijay Ramani labs reveal that our picture of how nucleosomes regulate DNA accessibility has been too simple. They find that over 85% of nucleosomes in mammalian cells are structurally distorted, with DNA partially accessible even while wrapped.

The illustration shows a tree bearing fruits that contain different vitamins branching from a trunk formed in the shape of DNA. It represents how our genes and nutrients intersect, resulting in the health of an organism. See the full paper: cell.com/cell/fulltext/…

Individualized medicine is moving from concept to reality. New FDA guidance supports therapies designed for single patients with ultra rare diseases. At Therna Biosciences, we are building an AI enabled RNA platform to make this possible. Link to our CEO’s post in the comments

Could the folding of synthetic gene circuits in 3D shape how genes are expressed? Today @ScienceMagazine we report on the role of gene syntax in shaping feedback between transcriptional activity and genome folding for advanced circuit design🧵 (1/n)

Scalable single-cell total RNA sequencing unifies coding and noncoding transcriptomics go.nature.com/4tjA7MI

🌟 Nematostella vectensis (starlet sea anemone) 🪼 A cnidarian model with deep evolutionary insights! 🧬 Nematostella reveals how germ layers and body axes evolved and can even regenerate its body after injury 🔁 📸 Image by Océane Tournière #ModelMonday #DevBio #EvoDevo

Glioblastoma Growth Mechanism Identified, Pointing to Potential Therapeutic Targets Findings highlight potential targets and could lead to development of therapies that specifically block tumor’s ability to spread @CCB_Research #GBM #immunesystem #tumors hubs.li/Q048gmNl0

Excited to share my postdoc work with @JD_Buenrostro now out in @Nature! "Epigenetic memory of colitis promotes tumour growth" nature.com/articles/s4158… We wanted to understand how transient inflammation can create a long-lived increase in cancer risk, even after full recovery 🧵

Our paper is out in @ScienceMagazine Here we describe how stem cell retain epigenetic inflammatory memory long-term. Full text in the link below! Congratulations @chris_cowley14 @SairajSajjath @LFSoto12 and everyone else involved! science.org/doi/10.1126/sc…