Bembenek Lab

As promised, here is our latest preprint! We identified a role for outer kinetochore proteins in vesicle trafficking, which was very surprising to us! 🧵to follow... biorxiv.org/content/10.110…

Mitotically Driven Cytoskeletal Reorganization Governs Zebrafish Left-Right Organizer Detachment from EVL and Lumen Morphogenesis biorxiv.org/content/10.648… #biorxiv_cellbio

My lab is accepting applications for a fully funded postdoctoral fellow position, beginning in 2027. Applicants must clearly articulate specific interests in our lab's research.

Yang et al show that #Celegans CKS-1 is required, w/ CDK-1, for #anaphase B during oocyte #meiosis I; promotes anaphase onset thru. securin & cyclin B1 destruction in meiosis I & II, respectively; & acts positively w/ both securin & cyclin B3 in meiosis II hubs.la/Q03_WFhj0

Spotlight: Moghareh, Bojorquez, and Lara-Gonzalez @ucirvine highlight work from Yang et al. (hubs.la/Q03_WPfB0) showing that CKS-1 plays key roles in both #anaphase B during #oocyte #meiosis I and the #metaphase II–to–anaphase II transition. hubs.la/Q03_WP970

Membrane rupture and independent extension of sister membranes drive cytokinesis in C. elegans embryos biorxiv.org/content/10.110…

How is timely and accurate sister chromatid separation achieved? A process that is happening around 30-50 billion times per minute!!! in the human body needs tight regulation (to avoid cancer development...). paper: lnkd.in/eHCYuyhc comment: lnkd.in/ezyw2dxi

Been doing a lot of time lapses of iPSC-derived cardiac muscle cells lately! Here's one of my favorites. This cell is expressing fluorescent alpha-actinin-2 and the colors represent depth. Movie length = 24h with frames taken every 20m. #microscopymonday #cellbiology @MAG2ART

Happy Halloween 👻🎃!

We won best group outfit!

Happy Halloween!

Interesting! micropublication.org/journals/biolo…

The nuclear localization of Ect2 is required for cytokinesis biorxiv.org/content/10.110… #biorxiv_cellbio

The centriculum, a membrane that surrounds C. elegans centrosomes, acts as a microtubule filter biorxiv.org/content/10.110… #biorxiv_cellbio

John Philip Trinkaus, a student in the 1939 Embryology course, left us with his drawings that show 'presumptive regions' in Trout, Fundulus, Dog fish, and Urodele; development of circulatory system of Teleost; and a squid spermatophore. bit.ly/4eZWxfU

You can always tell when the high school summer interns start working in the lab!

molbiolcell.org/doi/full/10.10… Very interesting review: "From my perspective, the study of spindle membranes seemed to take a back seat in the field of mitosis research..." Maybe it's time to address this?!?

I’m excited, relieved, and honored to announce that my paper describing non-canonical mitotic mechanisms in the early mouse embryo is out in @ScienceMagazine ! (link at end of 🧵)

🚨Preprint, RT appreciated🙏 Our work ‘Substrate recognition by human separase’ by @JunYu_unige, Sophia Schmidt, @MargheritaBotto @unige_en @UNIGEnews @MoCel_Geneva @DCI_EM and members from the Morgan @UCSF and @FJ_OReilly labs is online. 🔗biorxiv.org/content/10.110…

Henry and Devon’s paper, ‘Phosphate-binding pocket on cyclin B governs CDK substrate phosphorylation and mitotic timing’ is out today in @NatureComms! nature.com/articles/s4146…