Benjamin Basanta 🧉

I'm happy to share the publication of my postdoctoral work at the @LanderLab. We solved previously-unobserved conformations of human TTR, an 55kDa amyloid-forming protein, to great resolution. #CryoEM biorxiv.org/content/10.110…

New preprint! We measured temperature- and pH-induced aggregation for over 18,000 natural and de novo designed protein domains!

Preprint alert: Our work with the Greenberg lab is now in bio archives! Dream collaboration with the amazing Erin Duffy in which we show that RNA stability modulation is a major component of neural activity gene regulation. See bellow our x-plainer (formerly known as tweetorial)

Delighted to share that our cryo-EM work with @inmunova on engineered immunogens capable of eliciting neutralizing antibodies against hemolytic uremic syndrome is featured on the cover of Protein Science! 🔗 doi.org/10.1002/pro.70…

The human mitochondrial ClpXP is uniquely assembled and regulated compared to its bacterial counterparts. Congrats to Kelly Chen on her years of hard work on this challenging complex! biorxiv.org/content/10.110…

Huge congratulations to David Baker, Arzeda Co-Founder and Scientific Advisor, for being awarded the 2024 Nobel Prize in Chemistry! 🏆 Arzeda is the first protein design company to emerge from David's lab, contributing to breakthroughs in the field. nobelprize.org/prizes/chemist…

This is a huge validation of the importance of protein design. Arzeda cofounder David Baker is a gratifying choice. This signals the arrival of protein design as a fundamental tool in chemistry. I spent my PhD working on enzyme design.. and look where we are now!

Come be my colleague! UW Tacoma is hiring an Assistant Professor of Biochemistry. We're looking for someone excited about mentoring undergraduates in research, inclusive teaching, and being part of an interdisciplinary community of scholars. apply.interfolio.com/154390

Big News! Arzeda has closed a $38M oversubscribed funding round! This investment was led by top investors like @SofinnovaVC, @FallLineCapital, and & W.L. Gore & Associates tinyurl.com/bdemjjeh

Some thoughts on the current state of single particle cryo-EM map/model validation. (TLDR: preferred orientation remains a big problem, ❤️ Q-scores. There's been progress, but there's still more to do. ) authors.elsevier.com/sd/article/S09…

Excited to share that I am starting a lab focused on deep learning-based protein design, biophysics and fundamental biology at @MPI_Biochem and @GeneCenter_LMU in Munich with the Emmy Noether Programme this summer. Join us as a PhD or postdoc. More to follow soon!

New paper published in formal journal ! With @nachoquique and @eagalpern we explore the possibility of existence of extraterrestrial proteins. In sum: likelly! pnas.org/doi/10.1073/pn…

Finally our work on designing pH responsive antibody nanoparticles capable of disassembling at ~tunable~ pH, packaging and releasing cargo, and targeting specific cell surface receptors is out in @NatureSMB! nature.com/articles/s4159…

Thrilled to share that I will be joining the Faculty of UVA this August. We’re seeking enthusiastic candidates at all levels to join our team. If you’re interested, please reach out.

Our first foray into the fascinating field of DNA repair! Congrats to postdoc Chris Zerio @chriszerio, who tested hundreds of oligos to identify one that trapped the helicase of human Polymerase θ in the process of annealing two strands of DNA. tinyurl.com/jaddar9u

Thrilled to share my postdoctoral work in @Landerlab! The human Polymerase θ helicase undergoes conformational rearrangements to facilitate DNA microhomology annealing. These insights enable rational design of novel BRCA-deficient cancer therapeutics! tinyurl.com/jaddar9u

@Moto_Support I've tried contacting the support, but when I choose 'modems', the numbers I'm provided are constantly busy, ie, with the busy tone.

@BenjaminBsnt Hey there, Benjamin! Thanks for getting in touch with us. I'm really sorry to hear that you're experiencing some difficulties with your modem app. Just to clarify, you've contacted our Mobile support team.

Hey @Moto_Support how can I get a replacement for my modem that is still in warranty? The app doesn't work, both of your phone lines are constantly busy, I can't even dm you. Posting at support is all I can do. Seriously?

for the folks who missed @erincyang give a truly stellar seminar last week, you can how check out the recording 👇 youtu.be/FX7yBJKQuPg

Kicking off the 2024 Cold Spring Harbor CryoEM course @cshlcourses! It’s going to be a grueling but amazing 2 weeks!

Important update! Rosetta Commons has transitioned to a new #PublicRepository, expanding access & #collaboration in #ScientificResearch. Moving the repository brings the exciting possibility for contributions. The new repository is accessible at github.com/RosettaCommons…