Blake Sells

A dual therapy that targets conventional #dendritic cells can boost T cell-mediated antitumor immunity in #PancreaticCancer, according to a new study involving patient samples and mice. @DeNardoLabWUSM Learn more in Science #Immunology: scim.ag/3UZwFHM

Congratulations Dr. Hogg and team @SciImmunology: #dendritic cells can matter in #PancreaticCancer, patients. See it at scim.ag/3UZwFHM Big thanks to Swim Across America @SAA_Inc St. Louis and Pedal the Cause @pedalthecause for supporting this research and trial.

Skin fat plays by its own rules. We trace lineages (CellTagging), classify cell identity (Capybara), and model fate decisions (CellOracle) in our new Cell Stem Cell paper. It’s not a linear path. 🔗 doi.org/10.1016/j.stem…

1. Tertiary Lymphoid Structures (TLSs) – on demand lymphoid aggregates that assemble in inflamed tissues/cancer to regulate immunity   But how? What molecule triggers? What cells induce?   TODAY in @Nature nature.com/articles/s4158…   Long-term #PDAC survivor PART4 – TLSs   🧵1/25

New @NatureCancer paper from @SearsRosie @coussens_lisa and colleagues @OHSUKnight address the clinical question of why patients with #PancreaticCancer associated with lung only metastatic disease have a better prognosis than liver metastases. The answer lies in the ability to tolerate replication stress and the limited T cell immune response that accompanies such tolerance.

Thrilled to share our story out in Cancer Cell, led by the amazing Kay Hanggi (now on the job market). We show that necrotic forms of cell death and the subsequent release of IL1a drives myeloid-based immune suppression in models of breast cancer. (1/11) cell.com/cancer-cell/ab…

Many thanks to @DeNardoLabWUSM for their spotlight article on our cDC1 vaccine. 👉cell.com/trends/pharmac… ICYMI: our work in @ScienceMagazine by @krishnaniyer199 and colleagues: cDC1 vaccine facilitates curative immunotherapy in PDAC. 👉 science.org/doi/10.1126/sc…

RESEARCH | R Nakai, T Yokota, J Brestoff et al. (Osaka Univ, JPN; @washu_pathology) Administration of exogenous #mitochondria 💉or mitochondrial transfer from wild-type mice improves morbidity and mortality in a mouse model of #Leighsyndrome🐁 nature.com/articles/s4225…

Exciting to see this publication come out of the @PanCAN Therapeutic Accelerator Collaborative Awards - exactly what we set out to do. pancan.org/research/grant…

New @ScienceTM paper from @DeNardoLabWUSM (with @LabBeatty @bryant_kl & @VerastemOncolog) Stromal reprogramming overcomes resistance to RAS-MAPK inhibition to improve #PancreaticCancer responses to cytotoxic and immune therapy science.org/doi/10.1126/sc…

Congratulations Dr. Liu @SitemanCenter and collaborators @LabBeatty and K.Bryant on their featured article in @ScienceTM . And HUDGE THANKS to @PanCAN for bringing this team together and funding the trial that came out of the science with @verastemoncology.

Congratulations Dr. Liu and collaborators @LabBeatty and K.Bryant on their featured article in @ScienceTM. And HUDGE THANKS to @PanCAN for bringing this team together and funding the trial that came out of the science with @verastemoncology

A new generation of cancer-preventing vaccines could wipe out tumors before they form. Learn more: scim.ag/8o0 @NewsfromScience #ScienceMagArchives

Congratulations @mle_butka on a successful PhD defense today! 🎓🍾

@NCIsysbio A6: A study by @ItaiYanai & team shows tumor cells adapt to anticancer drug treatments by a series of cellular state transitions, each inducing distinct gene expression programs. They utilized scRNA-seq, ST, systematic genetic perturbations, ML techniques nature.com/articles/s4158…

Deep Metabolic Profiling of Immune Cells by Spectral Flow Cytometry – A Comprehensive Validation Approach dx.doi.org/10.2139/ssrn.4…

[1/2] IFNγ produced by γδ T cells stimulates ⬆️pancreatic β cells glucose-induced insulin release that ⬇️hepatic glucose output that ⬆️IFN-I levels by curtailing lactate inhibition of IRF3 & NF-κB signaling to aid responsiveness to viral pathogens nature.com/articles/s4159…

Intriguing paper in this week's Science: a new, much cheaper approach for MRI scanning It's an MRI scanner that uses a 0.05 Tesla magnet (vs. the current 1.5 - 3 T) and operates at a fraction of the cost (~$22,000 for the hardware), time (<10 minutes), and noise of a current MRI scanner Unlike current MRIs, the prototype scanner plugs into a standard wall socket, and doesn't need specialist shielding equipment It uses a deep learning (AI) strategy to improve the low signal-noise ratio that's inherent to lower field strength MRIs Although the images from the 0.05 T approach aren't as good as from 3 T MRI, they don't seem to be far off Zhao et al: science.org/doi/10.1126/sc…

“Fungi in cancer” on the cover of Nature Reviews Cancer. Perspective below: nature.com/articles/s4156…

Cool “bugs as drugs” preprint from @KenOliveLab to start off your Monday. Really great stuff Ken (who is on a roll!) Tumor-selective treatment of metastatic #PancreaticCancer with an engineered, probiotic living drug biorxiv.org/content/10.110… Photomicrograph showing acylhomoserine lactone activated engineered bacteria localized within primary & metastatic disease sites.