Coller Lab retweetledi
⭐️Check out the Perspective on cellular neighborhoods in cancer by @LichunMa, @KaiTanLab1 & co
🔗nature.com/articles/s4301…
Part of our Series on Tumor Heterogeneity and Plasticity:
nature.com/collections/gf…
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Coller Lab
63 posts
Coller Lab
@CollerLab
The Coller Lab uses modern approaches to investigate #quiescence, cell cycle control, #autophagy, and #cancer. Official account managed by the lab members.
UCLA Katılım Kasım 2021
186 Takip Edilen125 Takipçiler
Coller Lab retweetledi
Check out the latest from @Rachel_E_Savage, @JD_Buenrostro and many collaborators as part of the @IGVFConsortium
Rachel Savage@Rachel_E_Savage
It takes two (transcription factors) to tango Transcription factor collaboration enables precise T cell state engineering tinyurl.com/tcelltfs Excited to share our preprint with @JD_Buenrostro, @cgersbach, and an incredible team of collaborators as part of @IGVFConsortium 🧵
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Coller Lab retweetledi
⭐️Don't miss this Review published @NatureCancer
as part of our Series on Tumor Heterogeneity and Plasticity
'Heterogeneity and plasticity of cancer-associated fibroblasts'
✒️By Ruth Scherz-Shouval, Mara Sherman and co-authors
🔗nature.com/articles/s4301…
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Coller Lab retweetledi
(1/5) How does glioblastoma maintain its immense heterogeneity? 🧠 Two new companion papers from the Bhaduri Lab @UCLA now on @bioRxiv offer a lineage-resolved view of GBM hierarchies. Let’s dive in! 🧵👇
biorxiv.org/content/10.648…
biorxiv.org/content/10.110…
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Coller Lab retweetledi
We are excited to release a single-cell and spatial 3D epigenomic atlas of developing human basal ganglia and inhibitory neurons, part of our BICAN effort in collaboration with @lab_paredes @jernst98 @emukamel @CEpigenomics @bpasaniuc
biorxiv.org/content/10.648…
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Coller Lab retweetledi
Excited to share a recent publication from the lab. Daniel Benjamin & Jengmin Kang led the study of the allocation of resources to survival over reproduction in stem cells during aging. #EvolutionaryTradeOffs #SurvivorshipBias
science.org/doi/10.1126/sc…
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H4K20me3 and CTCF act reciprocally at TAD boundaries to regulate cell state transitions biorxiv.org/content/10.648… #biorxiv_cellbio
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We are so happy that Michael Cheng, a former undergraduate researcher in the lab and now a bioinformatics graduate student at @UCLA , will be defending his thesis this week (Wednesday at 1 pm; in person and on zoom). All the best, Michael!
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Coller Lab retweetledi
🆕🎧 New Podcast: The founding of PG is discussed in interviews with Drs. AW Cowley, Jr., B Joe, and HA Coller. These interviews were organized and conducted by @AkinolaTosinS.
Listen at ow.ly/L0MQ50Xok2H. Read the article at ow.ly/Vrxx50Xok2G.
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Coller Lab retweetledi
New @NatureGenet review from our NIH SenNet @sennetresearch OMICS WG co-led by @shenglilab
We share practical considerations for identifying, characterizing & spatially mapping #CellularSenescence, plus computational #multiomics insights!! nature.com/articles/s4158…
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Coller Lab retweetledi
Years ago we tried to model cancer-associated fibroblast (CAF) subtypes in vitro, but gave up because only the proliferative subtype survived culture (duh!). This study could change all that: Perturb-seq with CRISPRa of 1,836 TFs induces diverse fibroblast states in vitro(!). 👏
Anirban Maitra@Aiims1742
Fantastic work by @thenormanlab in @NatureGenet Recreating fibroblast diversity in vitro by activating transcription factors Demonstration of the power of CRISPRa Perturb-Seq to deregulate TF expression in fibroblasts (Function!) nature.com/articles/s4158… nature.com/articles/s4158…
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Coller Lab retweetledi
A new bridge recombination edit just dropped! 👀
Eric Topol@EricTopol
Why does the naked mole rat have the longest lifespan and healthspan of any rodent, nearly 40 years? A 30-year long mystery unraveled @ScienceMagazine today! Its cGAS enzyme in cells has 4 missense mutations that upends its function, promoting DNA repair and suppressing inflammation science.org/doi/10.1126/sc…
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Coller Lab retweetledi
Dr. Hilary Coller (@CollerLab) discussed her latest research on how epigenetic patterns can predict cancer outcomes more accurately than traditional markers. Her pan-cancer model reveals targetable epifactors across five tumor types.
Watch the talk here: bit.ly/4jEAMTU
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Coller Lab retweetledi
Join us for our next seminar with Dr. Hilary Coller of @UCLA! ➡️
youtube.com/watch?v=3bh0M9…
YouTube
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Coller Lab retweetledi
Less than one month away from abstract submission deadline for the 2025 GRC/GRS Genome Architecture meeting at the beautiful beach in California. Don't miss it!
Wei Xie@xielablife
Chromatin folks: don't miss GRC/GRS Genome Architecture in Cell Fate and Disease, June 15-20 2025 Ventura, CA. Registration deadline: Mar 18, 2025. grc.org/genome-archite…
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Kaiser is going to defend this doctoral thesis next week (Thursday, February 27th) at 9 AM in 158 Hershey Hall. Everyone is welcome to attend.
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Coller Lab retweetledi
In this review for our focus issue on patterns in molecular biology, @LuLaboratory explores how metabolites and metabolic enzymes regulate chromatin and histone modification patterns, highlighting the crosstalk between the metabolome and the epigenome.
cell.com/molecular-cell…
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Coller Lab retweetledi
CTCF stall DNA 🧬 loop ➰ extrusion by cohesin - but exactly how it pulls this off is a 'mechanistic mystery' (to cite
@Anders_S_Hansen , Nucleus, 2020). We just preprinted 📜 a new study @biorxivpreprint that provides some answers to this enigma: tinyurl.com/3r2a4ux2
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Our new review on "Transcription factor networks in cellular quiescence" is now published in @NatureCellBio. Thanks to the reviewers and the editor for the great suggestions and comments. Read here: rdcu.be/d5JFq nature.com/articles/s4155…
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