Colm O'Rourke

Sarah Michelle Gellar reacts to the overwhelming love and support from Buffy fans after the cancellation of the revival

Coney 1976 @BenStiller

Our latest CINDERELLA study is out! 💜 @OncJournal @iov_irccs Using Interpretable AI (IAI) , we move beyond "one-size-fits-all" 2L therapy for mPDAC. As RASolute-302 will potentially set a new standard, our study provides a real-world benchmark. academic.oup.com/oncolo/article…

New online! Neoadjuvant GOLP is effective in high-risk intrahepatic cholangiocarcinoma dlvr.it/TRZH7c

New paper in Cancer Discovery @CD_AACR reports on SPP1⁺ macrophage–IL-6–CRP inflammatory axis linked to resistance to checkpoint blockade in #bladdercancer. pubmed.ncbi.nlm.nih.gov/41747249/ mountsinai.org/about/newsroom… @michelle_a_tran @diegochowell @BhardwajLab @IcahnMountSinai

🧬 PROOF 301 — FGFR2-rearranged CCA 💊 Infigratinib vs GC (phase III) 📊 PFS (BICR) 7.4 vs 8.0 mo ❌ 📈 ORR 37.9% vs 15.8% ⚠️ Grade ≥3 AEs 79% vs 59% 🛑 Early termination (poor accrual) → no definitive conclusions 🔎 Trial design challenges in rare, biomarker-selected tumors 🔗 doi.org/10.1016/j.esmo… @OncoAlert

The OligoPanc project: an interdisciplinary expert consensus statement on oligometastatic pancreatic cancer - @TheLancetOncol thelancet.com/journals/lanon…

Tumor Debulking in Combination With Chemotherapy in Multiorgan Metastatic Colorectal Cancer: The ORCHESTRA Randomized Clinical Trial @JAMAOnc doi.org/10.1001/jama.2… 🧐even with modern chemotherapies, tumor debulking does not add anything.... @myESMO @ASCO

🚨Hot off the press👉Pleased to share my new commentary: "Matching hallmarks of cancer complexity with N-of-1 precision oncology" 🧬 @MedCellPress 👉A viewpoint on the latest iteration of Doug Hanahan's Hallmarks of Cancer framework and @Dr_R_Kurzrock 's the i-PREDICT trial, and what they mean together for #precisionmedicine 👉What is #PrecisionOncology 's E=MC2 ? Tweetorial soon. @OncoAlert @MedwatchKate @OpenMedicineHQ @oncodaily @Aiims1742 @neerajaiims @weldeiry @chadinabhan Free @CellPressNews link for 50 days authors.elsevier.com/a/1mm2C9UKeTtQ…

AI can make precision medicine more accessible. A new study shows AI can predict Oncotype DX scores, the test that decides if you need chemo in patients with breast cancer, using only routine pathology slides. @TheLancetOncol @OncoAlert @OncBrothers @grok @DeryaTR_

AI for cancer treatment information: Can academia stay in the game? dlvr.it/TRWgWH

🖥️ #ASCOAI: #Precisiononcology guided by #pathology slides. An AI-powered biomarker predicted differential response to gemcitabine vs fluoropyrimidine chemotherapy in advanced #pancreaticcancer. ✍️ Viswesh Krishna, BS of @valarlabs | @JCO_ASCO 🔗 ascoai.org/articles/2026/…

New work in @SciSignal exploits long noncoding RNAs in the “dark transcriptome” that possess anti-inflammatory properties by reengineering them to dampen acute inflammation in mice—a finding that could open a new field of lncRNA-based therapies. scim.ag/3OSovl3

That felt good. 🙌

Review @JExpMed @Casanova_Acebes Myeloid diversity in tumors: Shaped by genes, location, and time rupress.org/jem/article/22…

Suicide is now the LEADING cause of death for US medical residents. We are losing 500 physicians a year. That is an entire med school class. Stop demanding "resilience" from doctors and start fixing the system. Tie executive bonuses to wellness, not just RVUs. Link to the recent episode is in the comments 👇

Dog contact was linked to 64% lower 5-year mortality in cancer patients. Possible mechanisms include physical activity, psychosocial support, and microbiome changes.

Framework for cancer evolution profiling and interception in colorectal cancer: ASCEND-CRC program dlvr.it/TRTM8z