Deb Joye, PhD

📍 #Cosyne26 bound? Thrilled to have graduate students @annhuang42 and @sonjajohnsonyu representing the Rajan Lab this year. Shout out to co-first authors @tweetsatpreet and @neurostrow Catch their sessions to learn about our newest work 🧠🤖

Metabolite supplementation could offer a simple, low-cost way to improve CAR T cell therapy without any changes to the cells themselves. A clinical trial in r/r DLBCL is now enrolling (NCT06610344). Paper: cell.com/cell/fulltex... Announcement: arcinstitute.org/news/ketone-su…

To learn more about how this study fits into the broader scientific vision of the Levy Lab, read a Q&A with Innovation Investigator @MaayanLevyPhD: arcinstitute.org/news/meet-maay…

CAR T cell therapy has shown strong results against certain cancers, but metabolic exhaustion limits its effectiveness over time. In @CellCellPress, the @MaayanLevyPhD & @ChristophThaiss labs report that a common supplement can fuel CAR T cells to fight cancer more effectively.

Gut microbes signal the brain influencing age-associated memory and cognitive function in the experimental model @arcinstitute @Nature nature.com/articles/s4158…

We only experience time moving forward. But memory can both predict what comes next and reconstruct what must have happened before. In a new @biorxivpreprint preprint, we show how hippocampal development enables this flexible representation of time 🧵

We are excited to present our new study @Nature, led by @DrDrCox and performed in collaboration with the lab of @MaayanLevyPhD, in which we explore the impact of gut-brain axis aging on cognitive decline. nature.com/articles/s4158…

Today in @Nature, the @ChristophThaiss & @MaayanLevyPhD labs trace age-related memory loss to the gastrointestinal tract & map the complete gut-to-brain pathway driving it. Targeting this pathway can reverse cognitive aging in mice. nature.com/articles/d4158…

β-hydroxybutyrate fuels CAR T cells better than glucose, shifting them toward a more active, less exhausted state. Supplementation improved outcomes across cancer models & boosted T cell function in healthy volunteers.

Excited to share our new paper in @CellCellPress with @MarcoRuella, led by @Shan_Liu_ and @PuneethGuru_. CAR T cell therapy loses effectiveness over time due to metabolic exhaustion, but we found a surprisingly simple approach to address it. 👇 cell.com/cell/abstract/…

This work reflects a core question driving our lab: how can metabolites our bodies naturally produce become therapeutic tools? Read more about the paper and where we’re headed: arcinstitute.org/news/ketone-su… Free paper access here: authors.elsevier.com/c/1mjbpL7PXy2CY

Every time you experience something new, your brain faces a decision: Should it update an existing memory or create a new one? In our new paper in @JNeurosci, we isolate that exact decision, moment-by-moment during learning. 🧵

One thing I've learned about grad student interviews is to stop asking "Why do you want to go to graduate school?" and start asking candidates to reason backward from the end of the PhD. Who will you become? What will you do that you couldn't before? You learn so much more.

Evo 2, our genome language model that generalizes: - across biological prediction and design tasks, - across all modalities of the central dogma, - across molecular to genome scale, and - across all domains of life, is published today in @Nature.

@Nature @garykbrixi @BrianHie @genophoria @gdb @arcinstitute @nvidia @Stanford @UCSF @UCBerkeley @GoodfireAI @UW Oh yeah, we also wrote a short blog post: arcinstitute.org/news/evo-2-one…

Finally, here's the paper in @Nature: nature.com/articles/s4158… Very grateful to have been able to work with @garykbrixi @BrianHie @genophoria @gdb and many other amazing co-authors across @arcinstitute @nvidia @Stanford @UCSF @UCBerkeley @GoodfireAI @UW

Many labs have used Evo 2 in their own work. Check out some examples below, including the first AI-generated genomes or using Evo 2 for 3D genome analysis x.com/arcinstitute/s…

We developed Evo Designer to help you get started with Evo right away. This tool enables DNA generation from nucleotide and species prompts. Coding region annotation is provided, with 3D protein visualization (ESMFold) for prokaryotic sequences. Sequences are scored for perplexity and per-nucleotide entropy. Check out our tutorial here: youtube.com/watch?v=6P0L1q…

We also release Evo 2-20B, achieving 40B-level performance on a single H100, as a drop-in replacement. See Garyk's thread below x.com/garykbrixi/sta…

@AlisonFanton in our lab (developer of next-gen DNA recombinases) teamed up with @aditimerch (developer of Evo semantic mining) to experimentally demonstrate cell type-specific design of chromatin accessibility. We think combining generative foundation models with task-specific predictive models is a powerful paradigm