Luca Posa

Excited to share our new work here! A photocromic morphinian-azobenzene, efficacy switch and peripherally restricted analgesic. Great collaboration between Levitz lab, @DirkTrauner @sevakat1 @CorneliusGati! 👇🏻👇🏻biorxiv.org/content/10.110…

@Brimmer___ @Nick_Davidov Mr. von Baum here is a scientist, as I am a horse. He doesn’t know what he’s talking about, just spitting his racism out. Go back to the sewer, please.

@Nick_Davidov They get immigrant visas because the US is one of the best countries in the world for scientific research funding, job opportunity, and pay. All of the temporary visa ones are browns who want a US degree. The scientists want to stay here and are usually White or Asian.

The biggest bullshit move by DHS in its history. So everyone on a O1 or H1B visa would have to stop working legally in the US, go back to their country and wait for years of backlog? This includes top scientists in our universities, founders of billion dollar companies (at least 3 just in our portfolio would be affected by the way). And if we look at individual countries it becomes even more bs. Indians would have to wait decades. Russians don’t have anywhere to go (there is no US embassy in Russia, hello?). This is the worst imaginable way to disrupt important work for the country and pretend you’re fighting some loophole.

Wondering about pain and circadian rhythms? SCN→SPZ→PVN→vlPAG circuit maintains daily rhythms in pain sensitivity, but is dampened at night. science.org/doi/10.1126/sc…

@matteosalvinimi Disgustoso! Fare propaganda su tragedie come questa. E non una sola parola su L bracciante Bakari Sako pestatoce ucciso da ragazzini baby gang TUTTI ITALIANI. I neri si possono massacrare. Una vergogna la propaganda portata avanti da questo pagliaccio 🤡 (altro che ministro)

Italianissimo, laureato e perfettamente integrato, non vi pare? Chissà se qualcuno tenterà ancora di minimizzare l’attentato di Modena. Vediamo se tivù e stampa di sinistra censureranno anche queste parole d’amore… Avanti con la proposta di legge della Lega per revocare la cittadinanza e il permesso di soggiorno a chi commette gravi reati.

Half of laboratory mice are not what scientists think they are go.nature.com/4tAb5Zg

Somatostatin neurons in the midbrain control pain suppression during fear, their inhibition boosting analgesia while activation to the brainstem suppresses it, showing how threat circuits regulate pain signaling. biorxiv.org/content/10.110…

@BIONIC_Lab @AGungorAydin Can’t agree more. K99 get a very poorly fit reviewers.

@AGungorAydin K99 are weird, and you often get poorly fit reviewers that don't always understand your field. I got a 49% on a K99. That same grant got a 2% as a parent R01 on first submission.

After a depressing week, it's time to share that I could not get K99! I published 2 papers, 1 submitted to bioRxiv, and included 2 new preliminary data between A0 & A1 submissions (only 6 months). My score was 33 and I know it's not the best. However, they describe my research👇

Excited this paper is out @CellCellPress ! 🎉 This work explores the role of MOR and SST interneurons in ketamine’s antidepressant effect and identifies synergistic approaches to develop new therapeutics. Big shoutout to @hermanymv and all the team! cell.com/cell/abstract/…

Don’t miss our upcoming #PRF monthly webinar, featuring Drs. Frank Porreca, Kirsty Bannister, @PatrikErnfors, and @HJStratton13 on new developments in descending modulation next week! bit.ly/3NuY6Jq #pain #neuroscience #webinar

Check out the new @chromism placebo paper in @NeuroCellPress ! 🔥 Stoked that our lab could contribute 👇🏼 Activity capture + chemogenetic reactivation of a placebo analgesia ensemble in the vlPAG drives on-demand pain relief 💊 🧠 ⚡️ cell.com/neuron/fulltex… @PennMedicine

Salk Institute scientist Shrek Chalasani has been awarded up to $41.3 million from ARPA-H to advance a breakthrough technology he pioneered, sonogenetics, which uses ultrasound to precisely control cells within the body. This funding will help transform the Chalasani lab’s discovery into a potential noninvasive therapy for a range of conditions, including peripheral neuropathies. By enabling targeted control of mammalian cells without surgery, sonogenetics could redefine how we treat disease. Learn more: salk.edu/news-release/s… #SalkInstitute #ARPAH #Sonogenetics #Neuroscience #BiomedicalInnovation

@StefPuig @US_ASP Congratulations Anita and Matt!

Matthew Fanelli and Anita Khasnavis are talented students and my lab. Representing the lab at @US_ASP meeting in Philadelphia and doing a fantastic job! #proudPI Thank you @US_ASP for granting them a travel award which enabled their attendance to the meeting!

@natashajaques @sivareddyg I contacted two Canadian institutions, each twice, to get clarification. No answer. They have no idea what they are doing—such a waste of $ and false hope.

Are you a U.S. academic frustrated with the funding situation? Move to a Canadian institution and get $8M in research funding from the Government of Canada. Really interesting initiative! canada.ca/en/impact-plus…

Phone addiction and neural changes

A milestone of our photopharmacology ERC project, just up on bioRxiv! Light-dependent control of network activity in human brain tissue of patients with epilepsy &/or brain tumors using lidocaine photoswitches & a novel photocaged propofol. 1/2 biorxiv.org/content/10.648…

Did you see this result from @TawfikLab and @TheBorisLab in @Nature about a single dose of psilocybin’s effect on pain in mice? Check out @GregScherrer25’s #PapersoftheWeek pick on #PRF now bit.ly/4a3Co6Q

🚨BREAKING: Alex Pretti’s Colleagues Hold a Moment of Silence.

KOR - withdrawal - PAG 🔥 academic.oup.com/brain/advance-…

@GiorgiaMeloni @Antonio_Tajani Buffona 🤡

Insieme al Ministro degli Esteri @Antonio_Tajani abbiamo dato istruzione all’Ambasciatore d’Italia in Svizzera Gian Lorenzo Cornado di prendere immediatamente contatto con la procuratrice generale del Canton Vallese Béatrice Pilloud per rappresentarle la viva indignazione del Governo e dell’Italia di fronte alla decisione del Tribunale delle Misure Coercitive di Sion di scarcerare Jacques Moretti, nonostante l’estrema gravità del reato di cui è sospettato, le pesanti responsabilità che incombono su di lui, il persistente pericolo di fuga e l’evidente rischio di ulteriore inquinamento delle prove a suo carico. Una decisione che rappresenta una grave offesa e una ulteriore ferita inferta alle famiglie delle vittime della tragedia di Crans-Montana e di coloro che sono tuttora ricoverati in ospedale. L’Italia tutta chiede a gran voce verità e giustizia, e chiede che a ridosso di questa sciagura vengano adottati provvedimenti rispettosi, che tengano pienamente conto delle sofferenze e delle aspettative delle famiglie. Con il Ministro Tajani abbiamo quindi disposto il richiamo a Roma dell’Ambasciatore Cornado per definire le ulteriori azioni da intraprendere.

@OttoemezzoTW Solo lei. Diva 👠💄

Semplicemente, Lilli Gruber. #ottoemezzo

Great work by @FlyBottleEscape et al. identifying neurons responsible for the emotional burden of pain, and a genetic approach to ease suffering without relying on opioid drugs