Aaron Scott

A proud moment for the OncoAlert Network 🚨 Our #BreastCancer faculty member Dr. Rebecca Dent @RebeccaDSing is standing as a candidate for ESMO President — an honour that reflects a remarkable career dedicated to improving outcomes for patients worldwide. We extend our warmest congratulations to both Dr. Dent and Dr. Lordick on this recognition, and wish them both well.

What do you want Mike and I to discuss in the Webinar? Join us this Thursday and participate in the conversation :)

🎙️ A Cut Above podcast — The new episode is live now! What happens when there is no other option? In this episode, two pioneers of modern cardiac surgery, Tyrone David and Eduard Quintana, join A Cut Above for a deep dive into one of the speciality’s most feared and technically demanding operations: the Commando procedure. From radical reconstruction for infective endocarditis and massive annular calcification to the mindset required when there is “no other option”, this episode explores the anatomy, precision, and surgical courage behind these extraordinary cases. Along the way, it offers invaluable lessons on innovation, operative judgement, and the future of complex valve surgery. 🎧 Listen now ⛓️‍💥 eacts.org/publications/a…

🆙 #ASCO26 #LCSM Clinical Science Symposium 🔥Elisrasib (D3S-001, GDP-Bound KRAS G12C-i) as 1L Tx in KRAS G12C+ NSCLC ✅Mono: ORR 78% ✅+pembro: ORR 81.2%; PD-L1≥50%: ORR 95% 🎙️Dr. Shun Lu 🔢8511 ☑️NCT05410145 🔗 asco.org/abstracts-pres… @OncoAlert @Larvol @ASCO @KRASKickers

If the Protein Data Bank didn’t start ~50 years ago we might not have had AlphaFold. If the UK Biobank didn’t follow participants for 15+ years, medical genomics would be much worse off. Who is enabling AIxBio breakthroughs in the 2030s? What datasets are you betting on?

💥 “Low risk”, no therapy, no events… what could possibly go wrong? They took 205 “healthy-ish” individuals: No MACE No lipid-lowering therapy CAC ≤ 100 (and 54% had CAC = 0) So basically: 👉 the kind of patients we reassure every day And then we did something radical: 👉 we actually looked at their arteries over time (serial CCTA) 📉 What happened? Spoiler: not great. Total plaque almost doubled over ~5 years Non-calcified plaque grew the most Low-attenuation plaque: 👉 from 9% → 23% 🧠 Translation (in case the message is still too subtle) 👉 Atherosclerosis progresses 👉 Even when: - CAC is low - no events occur - no treatment is given 🧬 The uncomfortable biology This is the key: 👉 Disease progression is mostly non-calcified Which means: 👉 the most dangerous part of the disease is the least visible to CAC 🎯 And stenosis? Almost unchanged. Of course. Because: 👉 plaque evolves BEFORE it obstructs 🧠 My favorite part (the silent killer insight) We are still: 👉 using CAC = 0 👉 as a “reassurance tool” While in reality: 👉 CAC = 0 ≠ no disease 👉 CAC = 0 = “we’re just not seeing it yet” 🔥 The real message of this paper This is not a “natural history study” This is: 👉 a demonstration of how blind we are without plaque imaging 🚨 Final uncomfortable truth If you wait for: - stenosis - symptoms - events You are not practicing prevention. You are: 👉 watching biology unfold in slow motion

People think the rad tech just pushes a button. Here is what they actually do in the orthopedic OR: Manage intraoperative fluoroscopy in real time Optimize C-arm positioning and image quality Confirm implant alignment during joint replacement Enforce ALARA radiation safety for the entire team Participate in surgical time-out protocols Maintain equipment readiness throughout the case They hold active ARRT certification and, in most states, a state license on top of that. Their training covers anatomy, radiation physics, patient care, and aseptic technique. Every orthopedic surgeon depends on a skilled rad tech. The image on that screen does not happen without them. These professionals deserve far more recognition than they typically receive. #radtech

•Ast-PEG-Met conjugate reprogram macrophage metabolism via mitochondrial-targeted activation of AMPK-PPARγ axis and mitophagy. •ROS/pH-responsive hydrogel enables controlled release of astaxanthin and metformin to accelerate diabetic wound healing. sciencedirect.com/science/articl…

🦷 ISN co-signed the statement 12.5, led by @IADR, calling for integrating oral health into primary healthcare to strengthen prevention, early detection, and management of chronic diseases through person-centered, prevention-focused care aligned with the WHO Global Oral Health Action Plan. #KidneyHealthMatters #WHA79

How do genetics and modifiable risk interact in ath❓ Prof. Heribert Schunkert addresses this in a 🆕 @ATHjournal review, and will discuss it tonight during the Anitschkow Lecture at #EASCongress2026. 🕡 18:45–19:30 📍 Anitschkow Hall 🔗 atherosclerosis-journal.com/inpress #MyEAS2026

Now accruing: @SWOG S2419 led by @PBarataMD, @montypal, & @DrVaishampayan. The first phase 3 trial testing the addition of CBM-588 to IO-based front-line regimens in mRCC. @MosheOrnsteinMD @ReginaBarCar @NazliDizman @LauraBukavinaMD @YuWeiChenMD @katy_beckermann @PavlosMsaouel @PGrivasMDPhD @TwoOncDocs @bergsa83 @crisbergerot @KidneyCancer @kidneycan @OncoAlert

A full day of hands-on learning, practical discussions and coronary physiology in action 🫀 The Physiology Course brought early-career and experienced interventional cardiologists together in Paris today for an interactive educational experience. Today’s highlights 👇 #TPC #EuroPCR @BernardBruyne

Four organizations in Viet Nam were honored globally by WHO this week with #WorldNoTobaccoDay Awards for their outstanding contributions to protecting families and communities from tobacco-related harm! Vice Minister Mr Vu Manh Ha received the awards from WHO Director-General Dr Tedros Adhanom Ghebreyesus on behalf of all the award winners: 🏆Department of Legislation, Ministry of Health 🏆Health Policy and Strategy Institute 🏆Poison Control Center Bach Mai Hospital 🏆Viet Nam National Tobacco Control Fund. The awards celebrate Viet Nam’s commitment to a stronger and healthier future. Major recent milestones include tax reforms that are estimated to: ✅ Help 2.1 million people in Viet Nam quit or avoid smoking by 2031 ✅ Prevent 700,000 premature deaths over the coming decades ✅ Generate VND 24,000 billion in additional annual Government revenue by 2031 and ✅ Reduce access to low-cost cigarette brands, especially among vulnerable youth. ❤ WHO Viet Nam warmly congratulates all the award winners and is proud to be working together with you for a stronger, safer and healthier Viet Nam!

#AudioVisualAbstract : The Importance of a Pre-treatment Baseline When Screening Patients for #BreastCancer -Related #Lymphedema ow.ly/ovgT50Z2TSk @AndreaLMerrill @SyedAAhmad5

We just dropped the Colossal artificial egg: an incubation system that can raise and hatch a chick outside a natural eggshell. Getting to care for these little birds and watch them hatch is an incredible feeling. And this is just the beginning.

Stop blaming young people for being unemployed Amazon's UK boss 👇 the education system was not producing young people who are ready for work… @michelle2442323 bbc.co.uk/news/articles/…

Curated in partnership with GESTALT, the Spatial Theater at The Festival of Genomics, Biodata & AI will tell you everything you need to know about the applications of spatial omics. More info: hubs.la/Q04hDVNV0 #FOGBoston #spatialomics

Optimization of Postpartum Care for Patients With and at Risk for Premature and Long-Term Cardiovascular Disease: 2026 ACC Expert Consensus Decision Pathway: A Report of the American College of Cardiology Solution Set Oversight Committee jacc.org/doi/10.1016/j.…

I love talking about the microvasculature

#GileadNews: Today, we completed our acquisition of Tubulis, further strengthening our oncology portfolio with a next‑generation ADC platform and clinical‑stage programs with broad potential across multiple tumor types. Learn more: gilead.inc/3RCuZpf Learn more: