Anthony Grillo

Three years ago last week the Grillo Lab opened our doors. Today we toured the "new old chem" building that we'll move into next month. Excited for the future discoveries we'll make in the impressive space! #newPI #newbuilding

Ndufs4-/- mice: a testing ground for longevity interventions 🔘"This analysis serves as a useful guide for researchers utilizing this animal in the discovery of effective interventions for longevity and to prevent the onset of disease. 🔘It suggests there may be unprecedented underlying sex-specific differences in patients with Leigh syndrome and further strengthens the connection between normative aging and mitochondrial dysfunction." Jackson Nuss, @mkaeberlein, @BittoAlessandro, @GrilloAnthonyS link.springer.com/article/10.100…

Excited to share our latest publication in @GeroScienceAGE: "Ndufs4−/− mice: a testing ground for longevity interventions". link.springer.com/article/10.100…. In this paper, @GrilloAnthonyS and I introduce a transgenic mouse model exquisitely sensitive to longevity interventions. 🧵 1/n

🎉 Congratulations to the authors- Jackson Nuss, @mkaeberlein, @BittoAlessandro & @GrilloAnthonyS- on this insightful retrospective analysis using the Ndufs4 knockout mouse model of Leigh syndrome! Your work highlights important sex-specific differences and the potential of longevity interventions like 17α-estradiol in delaying disease progression. A valuable contribution to both mitochondrial disease and aging research! 👏🧬 #LongevityResearch #MitochondrialDisease #AgingScience #GeroScience rdcu.be/epFHh

We had a fantastic week in Bordeaux, France with the Science Without Borders Study Abroad Program through @ucinternational! Always great working with students on this global collaboration. #UCtheWorld

@ishahjain Congrats! It was fantastic to read.

🚨 New paper alert! 🚨 Check out our latest work on HypoxyStat, a small-molecule therapy that increases oxygen-hemoglobin affinity and provides a practical form of hypoxia therapy. A great collaboration with @MazeInBiotech 🔗 Paper: doi.org/10.1016/j.cell… @CellCellPress

Pleased to announce our lab's latest pre-print by graduate student @mariahcalubag "Tissue-specific effects of dietary protein on cellular senescence are mediated by branched-chain amino acids" biorxiv.org/content/10.110…

@LammingLab @mariahcalubag Great work! Congrats to the team.

Happy Holidays from the Grillo Lab! It was a fantastic third year, and we look forward to an exciting year ahead. It is important to stop to celebrate and appreciate our accomplishments and hard work. I loved our Potluck and "Secret Tony" to end the year! #mitochondria

Hypoxia in a pill! Chronic, continuous 11% FIO2 suppresses brain pathology in models of mitochondrial disease and aging, but we need practical alternatives. We combine a Hb "left-shifter" with a HIF2a inhibitor to achieve therapeutic hypoxia in mice. jci.org/articles/view/…

Some exciting news to share! Our lab is relocating to the Department of Biochemistry and Molecular Genetics (med.virginia.edu/bmg/) @MedicineUVA in January 2025! We're actively recruiting talented postdocs to join our team. Please RT to spread the word.

Are you a #biochemist looking for a #tenuretrack #facultyjob? Come join our growing and thriving department! @GrilloAnthonyS and @RossLabUC are co-chairing a search for a Biochemistry TT Assistant Professor. @uofcincy @UC_ArtSci #Chemjobs jobs.uc.edu/job/Cincinnati…

Excited to have the opportunity to help plan such an outstanding event. Please consider coming to St. Louis next summer to attend the annual UMDF Mitochondrial Medicine conference!

Are you a #biochemist looking for a #tenuretrack #facultyjob? My colleague @GrilloAnthonyS and I are co-chairing the search & we are looking for an excellent colleague to join our growing and thriving department @UcChem @uofcincy @UC_ArtSci #Chemjobs tinyurl.com/2ukfwxt7

Very excited to share our latest paper out today @NatMetabolism showing that #mitochondria transfer and transplantation may reduce the morbidity and mortality of #LeighSyndrome, a fatal mitochondrial disease with no effective therapies. dlvr.it/TCjPl6

What I don't get about academia is the chronic lack of celebration. It is hard to get & maintain grant funding, hard to get papers accepted without Faustian bargains, hard to be a great mentor, & hard to maximize trainee success. All of it is hard. We should celebrate everything.

We love a healthy debate. @mkaeberlein's lab members got together to discuss/disagree with each other about various longevity interventions at the recent @americanaging meeting. youtu.be/Itx1FvJfDXc

Did you know @mkaeberlein used to head a lab @UW? He gathered former lab members for a lively debate about longevity interventions such as acarbose, sauna, NAD+, hyperbaric oxygen therapy, and many more. youtu.be/Itx1FvJfDXc

The Grillo Lab had a lot to celebrate after our annual lab clean up! We had our inaugural awards ceremony, followed by a fun team-building event at an Escape Room, and finished with an excellent dinner. Congrats to everyone in the lab! #WorkHardPlayHard #PeopleOverProjects #newPI