Isnard Pierre

Check out our recent work on @NatureComms! Greatly appreciate my mentors and collaborators making this possible. We developed epi-Patho-DBiT, a unified platform that enables spatially resolved ATAC -seq or CUT&Tag analyses in FFPE tissues!

@HaikuoLi @NatureComms Congrats !!

We generated a spatial atlas from 64 human kidney samples to define kidney niches and characterize fibrosis through injured tubular microenvironments. We built a spatial immune atlas to study renal inflammation, uncovering a B cell-predominant immune microenvironment in DKD that correlated with disease severity and kidney function decline.

Congrats to @IsnardPierre1 and Marco Pontoglio HNF1B integrates signals in a feed-forward loop driving kidney disease progression | Happy to have contributed with Jon Levinsohn @ScienceMagazine science.org/doi/10.1126/sc…

Thrilled to share our work! Immensely grateful to my incredible mentors, Fabiola and Marco, to all co-authors, and to Science for publishing and supporting our work ! science.org/doi/10.1126/sc…

🚨 Our new paper just dropped !!! Proteomic risk score for early prediction of kidney disease progression in individuals with APOL1 high-risk genotypes nature.com/articles/s4159…

Nature research paper: Multiomics and deep learning dissect regulatory syntax in human development go.nature.com/4cinsmn

I am very pleased with our latest paper, spearheaded by 3 incredibly talented first authors @chris_cowley14,@LFSoto12 and @SairajSajjath with @ElaineFuchsLab. Here we show that cells can remember past injury for a long time! science.org/doi/10.1126/sc…

Bx for AKI in a pt on checkpoint inhibitor: neutrophil rich tubulointerstitial nephritis. We would usually think pyelonephritis, high risk neutrophil rich variants of CKI inhibitor AIN have been characterized. pubmed.ncbi.nlm.nih.gov/41727781/ #renalpath #pathtwitter #nephrology

Whole-body molecular and cellular mapping of the laboratory mouse @CellCellPress @UChicagoPME cell.com/cell/fulltext/… 🇨🇳🇺🇸

What extraordinary news — I’m extremely proud and honored. Thank you @eshgsociety for this very prestigious award, which I share with the entire team. 🎉🍾🥂

Always special to write papers with @kidneyomicsamps, good friend, colleague, and neighbor (@broadinstitute & @TownofBrookline) jamanetwork.com/journals/jaman… @JAMANetworkOpen

Trimodal single-cell profiling of transcriptome, epigenome and 3D genome in complex tissues with scHiCAR go.nature.com/4rZqimf

Thrilled to share our latest report: a challenging case of post-transplant graft dysfunction in a rare metabolic disorder: kidney-international.org/article/S0085-…

Integrating single-nucleus barcoding with spatial transcriptomics via Stamp-seq to reveal immunotherapy response-enhancing functional modules in NSCLC rdcu.be/e35I5

Original Article: Sibeprenlimab in IgA Nephropathy — Interim Analysis of a Phase 3 Trial (VISIONARY trial) nej.md/493Xtza Editorial: Targeting the Pathogenesis of IgA Nephropathy — A New Treatment Approach? nej.md/4too8hy #Nephrology #Immunology

HumanBase: an interactive AI platform for human biology nature.com/articles/s4159…

Single Cell Atlas: a single-cell multi-omics human cell encyclopedia genomebiology.biomedcentral.com/articles/10.11…

Endothelial cell–released CD93 contributes to podocyte injury in idiopathic nephrotic syndrome | ⁦@ScienceTM⁩ ⁦@carafuentes_g⁩ science.org/doi/10.1126/sc…

New Article! Single-nucleus chromatin accessibility and gene expression co-profiling by ISSAAC-seq dlvr.it/TQJ055