Isnard Pierre

What extraordinary news — I’m extremely proud and honored. Thank you @eshgsociety for this very prestigious award, which I share with the entire team. 🎉🍾🥂

Always special to write papers with @kidneyomicsamps, good friend, colleague, and neighbor (@broadinstitute & @TownofBrookline) jamanetwork.com/journals/jaman… @JAMANetworkOpen

Trimodal single-cell profiling of transcriptome, epigenome and 3D genome in complex tissues with scHiCAR go.nature.com/4rZqimf

Thrilled to share our latest report: a challenging case of post-transplant graft dysfunction in a rare metabolic disorder: kidney-international.org/article/S0085-…

Integrating single-nucleus barcoding with spatial transcriptomics via Stamp-seq to reveal immunotherapy response-enhancing functional modules in NSCLC rdcu.be/e35I5

Original Article: Sibeprenlimab in IgA Nephropathy — Interim Analysis of a Phase 3 Trial (VISIONARY trial) nej.md/493Xtza Editorial: Targeting the Pathogenesis of IgA Nephropathy — A New Treatment Approach? nej.md/4too8hy #Nephrology #Immunology

HumanBase: an interactive AI platform for human biology nature.com/articles/s4159…

Single Cell Atlas: a single-cell multi-omics human cell encyclopedia genomebiology.biomedcentral.com/articles/10.11…

Endothelial cell–released CD93 contributes to podocyte injury in idiopathic nephrotic syndrome | ⁦@ScienceTM⁩ ⁦@carafuentes_g⁩ science.org/doi/10.1126/sc…

New Article! Single-nucleus chromatin accessibility and gene expression co-profiling by ISSAAC-seq dlvr.it/TQJ055

Mapping isoforms and regulatory mechanisms from spatial transcriptomics data with SPLISOSM go.nature.com/3NaXw31

Revealing a coherent cell-state landscape across single-cell datasets with CONCORD go.nature.com/4jsNxSL

The SpatialEx(+) framework uses histology to generate and integrate complementary spatial multi-omics data across samples. nature.com/articles/s4159…

🚨 Just out from our lab in @CircAHA! 🚨 We know APOL1 risk variants (RVs) cause FSGS. But what about Hypertension-Attributed Kidney Disease (H-CKD)? 🤔 H-CKD is distinct: slowly progressing, low albuminuria, and massive vascular damage. Is it just secondary to kidney injury? Or is it a primary vascular defect? We found the answer.🧵👇ahajournals.org/eprint/TNWJK5I…

Renal PIEZO2 is an essential regulator of renin: ⁦@CellCellPress⁩ ⁦@ardemp⁩ ⁦@JPetiPeterdi⁩ cell.com/cell/fulltext/…

Standardized metrics for assessment and reproducibility of imaging-based spatial transcriptomics datasets go.nature.com/4rBC1Z0

🗨️ Just published in @NatureBiotech: Our CellWhisperer AI enables chat-based analysis of single-cell sequencing data. You can talk to your cells & figure out the biology without writing any computer code. Paper link and annotated walkthrough in the thread below (1/11)

Our latest review on kidney drug repositioning in @Kidney_Int. Congrats to the 2 outstanding contributors @morin_gbrl and @IsnardPierre1👏🍾🥂Drug repurposing in PIK3CA-related overgrowth spectrum: breakthroughs from overgrowth syndromes to kidney disease kidney-international.org/article/S0085-…

Our new paper in @naturemethods led by @vanvanka123 @MingboCheng Jitske Jansen with ⁦@KuppeChristoph⁩ nature.com/articles/s4159…

Our new study in Science is out! CKD progresses slower in females. 🔹Estrogens boost female renal progenitors to produce new podocytes for pregnancy adaptation. 🔹Loss of this mechanism causes preeclampsia, maternal CKD risk & fewer nephrons in offspring. science.org/doi/10.1126/sc…