Jason Goodman

@PeterRahal @jacob_posel Truth.

@jacob_posel They are accurate, you cannot use a bomb calorimeter to measure non-nutritive foods like fiber, allulose, or epg

Ugh

@andrewchen I am a non-technical Excel wizard and am embracing Claude modeling. This is the future.

reading the replies -- a lotta folks hate this prediction! A lot of folks can't imagine programming the logic/variables/inputs without the spreadsheet grid paradigm my primary counterpoint: - much complaining is from people trained on keyboard shortcuts in Windows Excel on Thinkpads during their glorious banking days, swearing that they'll never switch to anything else. Late adopter normie finance bros. Soon to be disrupted my actual counterpoints: - programming itself has changed its UX many many times. Punchcards, typing into files, IDEs, and now LLM coding harnesses. Spreadsheets are not the only way to encode business logic -- there are better ways, while gaining all the power of software - the grid UX might remain in some form, but might be more of a display. Just as you code in Codex/Claude but then still pull up a webpage. Or maybe you'll have a grid as a DB but then build apps on top, but still want a querying UI for the data - LLMs will make going between logic in code and logic in spreadsheets interchangeable. So maybe you'll edit in a grid but then hit "deploy" and it'll build a webapp in the cloud. And just as we have VLOOKUP() they'll be LLM() that can encode AI logic - anyone who works with software knows its infinitely better and more expressive and more powerful. AI code gen is a blessing for all the non-technical excel wizards who can now take their work to the next level

prediction re the end of spreadsheets AI code gen means that anything that is currently modeled as a spreadsheet is better modeled in code. You get all the advantages of software - libraries, open source, AI, all the complexity and expressiveness. think about what spreadsheets actually are: they're business logic that's trapped in a grid. Pricing models, financial forecasts, inventory trackers, marketing attribution - these are all fundamentally *programs* that we've been writing in the worst possible IDE. No version control, no testing, no modularity. Just a fragile web of cell references that breaks when someone inserts a row. The only reason spreadsheets won is that the barrier to writing real software was too high. A finance analyst could learn =VLOOKUP in an afternoon but couldn't learn Python in a month. AI code gen flips that equation completely. Now the same analyst describes what they want in plain English, and gets a real application - with a database, a UI, error handling, the works. The marginal effort to go from "spreadsheet" to "software" just collapsed to near zero. this is a massive unlock. There are ~1 billion spreadsheet users worldwide. Most of them are building janky software without realizing it. When even 10% of those use cases migrate to actual code, you get an explosion of new micro-applications that look nothing like traditional software. Internal tools that used to live in a shared Google Sheet now become real products. The "shadow IT" spreadsheet that runs half the company's operations finally gets proper infrastructure. The interesting second-order effect: the spreadsheet was the great equalizer that let non-technical people build things. AI code gen is the *next* great equalizer, but the ceiling is 100x higher. We're about to see what happens when a billion knowledge workers can build real software.

@pmarca Excel

Dozen most important post-punch-card software? AT&T/BSD/Linux Unix kernel GNU suite/GCC VisiCalc WordPerfect MacOS/iOS GL/Doom/Quake JavaScript PageRank/Backrub/Google GPT 1/2/3/4/5 GPT O1/Deepseek R1 OpenClaw/Pi Anything missing?

@thefoodbabe Kellogg's doesn't exist anymore.

So who’s boycotting #Kelloggs like FOREVER? 🙋🏻‍♀️🫶🏽

@DrNeilStone ...which can be cured by abstaining from seed oils and sunscreen.

It's a short road on this site from "I'm not sure about these vaccines" to "vaccines give you AIDS and cancer "

Why couldn't anyone hear the cow on Zoom? She was moo ted

@thefoodbabe @womenshealth I remember when everyone was eating whole unprocessed diets in the 1800s and it cured their polio. Eating healthy is great but medicine is medicine.

What's 1 thing you're doing to stay healthy & prevent #ChronicDisease? Join @womenshealth for #OneThingForMyHealth during #NWHW & share a photo of how you prioritize your health: womenshealth.gov/nwhw/resources…

@Mark_Sisson This is based on what

In the long run, some alcohol will be shown to be healthier than none.

@ryanburge Super interesting. Thank you. Me living in this post grad bubble.

Among white voters. Here's the Democrat's coalition: People who never attend church. Especially those with an associate's degree or more. Here's the Republican coalition: People who attend church once a year or more.

@DoctorTro "...just overcome that with constant presentations of food to leverage cephalic phase responses impact over hormonally mediated hunger signals. Brilliant, but nefarious." You described the modern food environment in US.

Kevin Hall is a master of trial design and a master of obfuscation. The deeper you go, the more understanding of this you will have. The only people who can see this are masters of trial design and those who understand how to manipulate trial design for desired outcomes. Doing a 90 minutes PET MRI on humans after milkshakes is just stupid. But great for publicity. CNN and MSNBC interviews are super cool, book coming soon I imagine... His friend Gardner is also a master at this, the twin study was a publicity stunt and the outcomes including effects on metabolic health (which worsened) were buried, just like his Keto-Med study which buried that patients on keto stopped more diabetes meds. What many in the space understand is that these scientists are brilliant, but their intentions need to be properly elucidated and their trial design actively monitored, because the results have been disastrous and wasteful. Its tough to see this point, but these two scientists should either retire or agree to collaborative arrangements that properly address manipulative trial designs before they waste millions of dollars. Here is a point about Hall's ward studies. It is well known that low carb diets decrease ad-lib intake over 2-5 hours compared to high-carb, but a great way to overcome this is to force 3 meals and 2 snacks... in mandated mess hall arrangement and the persistent presentation of snacks... this is why inpatient metabolic wards with ideal trial design for an intended outcome are problematic. If a diet makes you less hungry and less likely to initiate eating, just overcome that with constant presentations of food to leverage cephalic phase responses impact over hormonally mediated hunger signals. Brilliant, but nefarious. Take another example, DIETFITS stopped sugar and flour in BOTH arms.... The only reason to do this is to equalize arms. No other reason. Brilliant "science" but nefarious. These people need to leave, IMVHO. They are cancer for progress. They best way to utilize their brilliance would be to pair them with strong opposing voices that can counteract the implicit/explicit bias but this is likely not feasible interpersonally. Best bet for NIH is to give another group a valid shot. The last 5 decades were disastrous.

@KevinH_PhD What a loss. I've been super inspired by your work, and your principled decision here. Our company hopes to use the next paper as guidance for all of our snack reformulations. Excited for what's next.

After 21 years at my dream job, I’m very sad to announce my early retirement from the National Institutes of Health. My life’s work has been to scientifically study how our food environment affects what we eat, and how what we eat affects our physiology. Lately, I’ve focused on unravelling the reasons why diets high in ultra-processed food are linked to epidemic proportions of chronic diseases such as diabetes and obesity. Our research leads the world on this topic. Given recent bipartisan goals to prevent diet-related chronic diseases, and new agency leadership professing to prioritize scientific investigation of ultra-processed foods, I had hoped to expand our research program with ambitious plans to more rapidly and efficiently determine how our food is likely making Americans chronically sick. Unfortunately, recent events have made me question whether NIH continues to be a place where I can freely conduct unbiased science. Specifically, I experienced censorship in the reporting of our research because of agency concerns that it did not appear to fully support preconceived narratives of my agency’s leadership about ultra-processed food addiction. I was hoping this was an aberration. So, weeks ago I wrote to my agency’s leadership expressing my concerns and requested time to discuss these issues, but I never received a response. Without any reassurance there wouldn’t be continued censorship or meddling in our research, I felt compelled to accept early retirement to preserve health insurance for my family. (Resigning later in protest of any future meddling or censorship would result in losing that benefit.) Due to very tight deadlines to make this decision, I don’t yet have plans for my future career. The NIH has been a wonderful place because it allows scientists to take risks, form unique collaborations, and do studies difficult to conduct elsewhere. I’m proud of what we’ve accomplished and I’m fortunate to have had such wonderful colleagues and scientific collaborators. I hope to someday return to government service and lead a research program that will continue to provide gold-standard science to make Americans healthy.

@drmarkhyman Is there a paper to review that lists out these correlations?

Strongly recommend watching this, irrespective of whether you’re a Tucker fan. There is growing scientific concern around the role of the spike protein—whether from the SARS-CoV-2 virus or generated in response to mRNA vaccines—in contributing to immune system dysregulation. Dr. Soon-Shiong is right to raise the alarm: the potential for long-term immune suppression is a legitimate public health concern, and one I share. We’re now seeing a marked rise in chronic diseases, immune dysfunction, long-COVID, and other serious conditions. While correlation doesn’t equal causation, these trends deserve honest inquiry, rigorous research, and open scientific dialogue—not dismissal. @SecKennedy @DrJBhattacharya - let’s investigate this closely.

@chamath Abundance.

This image is increasingly our reality. On many important dimensions, China is ahead. If they win the technology race, they will win the economic and military ones as well. If the win all three, they become the leading force in the world. We can’t let that happen. We’re losing headed into the fourth quarter. We need infinite power, infinite compute and simpler legislation if America is going to catch up to China and beat them. Infinite power means preserving the status quo (ITC credits + transferability) while green-lighting as many new projects as possible across all power modes - nat gas, coal, nuclear, wind and solar. Infinite compute means rapidly replacing Taiwanese dependencies on chip manufacturing with American ones. Simpler legislation is self explanatory. Wading through myriad laws and rules that often conflict with itself makes moving quickly impossible. For every new rule or law, remove 10 old ones. We need to move quickly but winning is still possible.

"let's swap fat sources in our 650kcal/1400mg sodium (per large serving) fries" Glad to see we are taking nutrition seriously again.

@drmarkhyman Hi Mark, can you share your source on that 90% number?

90% of disease is related to the exposome—not your genes. That means what you eat, how you live, your relationships, and your environment determine your health more than your genetics.

@DKThomp Hi Derek, I'm a food scientist with food company working in this space. We also released a GLP-1 focused podcast today and we both told the same Gila monster story. open.spotify.com/episode/2Zl4Bi…

New ep: Are GLP-1s "the greatest medical breakthrough of the 21st century"? A new study of 2m Veterans Affairs patients with diabetes found GLP1 use was associated with a reduced risk of: - substance use disorders - psychotic disorders - Alzheimer's and dementia - clotting and heart attacks - infectious illnesses - several respiratory conditions To be blunt: WTAF is going on here? How did we turn synthesized Gila monster spit into a drug that seems to control diabetes, promote weight loss, and have such a absurdly wide range of positive effectiveness? Today we speak with @zalaly, an author of the new paper. What did his research look at? Why should we trust it? Where was the strongest signal? What new risks did we uncover? How on earth can a single drug do all of this? And how is it teaching us more deeply about "pleiotropic" medicine—single drugs that have a zillion unrelated positive side effects—and even the nature of willpower and free will in health? open.spotify.com/episode/0UtT3D…

Believe Science, Not Hype RFK Jr. & influencers call seed oils "poison," but research shows they can be part of a healthy diet. The real issue? Misinformation. As @neiltyson says, “Science is true, whether or not you believe in it.” My @MSNBC op-ed: msnbc.com/opinion/msnbc-…

@AlpacaAurelius This paper doesn't seem to exist online. Do you mind linking the PDF so we can see the study and evaluate the claim?

Soybean oil is incredibly estrogenic...It's activity is equal to 60% of the effect of taking estrogen directly. Meaning enough soybean oil is basically like taking birth control. Avoid.

@iiiitsandrea Max Richter - The "Leftovers" score / soundtrack top recommendation.

a little bit of everything this year 🥰