Sarah Jäkel

1) bioinformatically, MT-genes are not always a good marker for bad quality cells and this approach should be reconsidered. 2) cellular pathology can look quite different in different brain regions and 3) oligodendrocytes (and other cells) downregulate canonical markers in AD.

I dont know how much science is still happening here...but lets see. We have just released the first major paper of the Jäkel lab! biorxiv.org/content/10.648… Looking at scRNA-seq in human AD brains with a major focus on oligodendrocytes, we made some interesting findings:

Working part time as a parent in certain positions is probably the biggest scam. You are still expected to do the same amount of work in less time for less money.

Really emjoyed our session yesterday afternoon at #GLIA2025 on oligodendrocytes with @LuiseASeeker @GoCasteloBranco and others. We had a brilliant discussion aftwrwards. The glia community is always great!

Excited 2 be in Marseille for our symposium on understanding human oligodendroglia: a lifespan perspective at #GLIA2025. Join the brilliant @GoCasteloBranco, Sarah Jäkel, Nina Kazakou, Sunniva Bøstrand and myself. We are presenting exciting human data generated with @10xGenomics.

Hurler et al. report that fixation times affect mRNA detection in post-mortem human brain tissue, highlighting the need for standardised protocols to ensure reliable and comparable results in mRNA studies. Read at:buff.ly/4hSYhYA @JekyllSarah #mRNA #neuroscience

onlinelibrary.wiley.com/doi/10.1002/gl… Our paper is now out in GLIA! Excellent work led by @vidramesh and supported by @sidb_edinburgh. Thank you to everyone involved, especially to @e_tsou @Ioannakougianou @odando @Zrile

@lidazoupi @vidramesh @sidb_edinburgh @e_tsou @Ioannakougianou @Zrile Congratulations 😍🤩

Our new pipeline is out! In this work we detail an ex vivo versatile platform for assessing myelin dynamics of hiPSC oligodendroglia. 🔗 Check it out @STARProtocols: doi.org/10.1016/j.xpro… Huge thanks to my mentor @ErinMGibson and collaborators @LidaZoupi and @AnnaWilliamsLab!

Today marks a special day in my career - I received the official document that as of February, I will be a professor at TU in Munich. There are certainly many people who supported me all along the way to achieve this goal. I am really looking forward to the next steps.

So happy to be involved in this project. Very important work linking amyloid and tau pathology. science.org/doi/10.1126/sc…

@nfranzme @matbrendel @AnnaSteward_ @AnnaDewenter @_michael_scholl @amirdehsarvi @M_Malpetti Looking forward to the follow up project!

6/Many many thanks to everyone involved in this huge effort, including @matbrendel, @AnnaSteward_, @AnnaDewenter, @_michael_scholl, @amirdehsarvi, @M_Malpetti, @JekyllSarah and many more!

Incredibly happy and proud to share our newest work in @ScienceTM showing that Aβ promotes neuronal hyperconnectivity, thereby driving tau spread across connected brain regions. Many thanks to to first authors @SebRoemer and Fabian Wagner! science.org/doi/10.1126/sc… Thread below

@AOSasmita @NeuroCellPress congratulations!!

Are you using 5xFAD mice to study Alzheimer’s disease? Our work @NeuroCellPress may be relevant to you 🐁 Age and sex are known to influence Aβ plaque burden in these mice. Here, we found that the transgene parentage is another strong determinant. (1/11) cell.com/neuron/fulltex…

Did you ever wonder about the role of oligodendrocytes in Parkinson's disease? Check out our new unsolved mysteries article together with @burbulla_lab - and be certain that this topic is just at the beginning of being explored! journals.plos.org/plosbiology/ar…

Neuroinflammation in Alzheimer disease: I feel very privileged to have contributed to this excellent review led by Prof. @michael_heneka together with other leading experts in the field. #citeas" target="_blank" rel="nofollow noopener">nature.com/articles/s4157…

So glad to see this work finally out. A huge collaborative effort, and besides the biological findings, also a brilliant resource. sciencedirect.com/science/articl…

Positive #MS research news just before Christmas! A team co-led by @AnnaWilliamsLab has published gene expression findings from post-mortem samples that separate MS brain samples into 4 groups. Paves the way for personalised treatments. More at annerowlingclinic.org/about/news/ms-…

@liebscher_lab Thank you for all your work and help also outside this project 😊

Congratulations Sarah! Fixation time matters for many processes including RNAscope - really important work.

@MA_Karreman @liebscher_lab Thank you 😊

@JekyllSarah @liebscher_lab Congratulations Sarah!!

The first paper of the Jäkel lab is published! Are you working with post-mortem brain tissue and want to detect RNA in FFPE tissue? Then you should consider the fixation time before your experiment. Nice collaboration with @liebscher_lab doi.org/10.1093/brainc…