Sebastian Roemer-Cassiano

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Sebastian Roemer-Cassiano

Sebastian Roemer-Cassiano

@SebRoemer

@sebroemer.bsky.social Clinician Scientist at Franzmeier-Lab ISD; Resident Physician in Neurology at LMU Munich; Max Planck School of Cognition PhD

München, Bayern Katılım Şubat 2013
210 Takip Edilen135 Takipçiler
Sebastian Roemer-Cassiano retweetledi
Nico Franzmeier
Nico Franzmeier@nfranzme·
Out now in Brain: Our new study co-led by @matbrendel shows that tau deposits in Alzheimer’s disease not affect gray matter but also drive degeneration of connected white matter tracts, offering mechanistic insight into how tau disrupts brain networks academic.oup.com/brain/article-…
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Sebastian Roemer-Cassiano
Sebastian Roemer-Cassiano@SebRoemer·
1/ What a session. I believe I saw people sleeping in front of the door to get a seat in the first row when doors opened! Thanks to #AAIC25 for giving us the opportunity to organize this FRS, and thanks to everyone who came and participated in the cool discussion!
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Sebastian Roemer-Cassiano
Sebastian Roemer-Cassiano@SebRoemer·
2/3: Innovative topics by Yu Xiao, @fislarissa, @HeidiJacobsLab, Jessica Peter, Arnold Bakker and myself are awaiting you, chaired by @anne_maass and Bill Jagust. It was great fun organising this FRS and I am looking forward to some interesting discussions.
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Sebastian Roemer-Cassiano
Sebastian Roemer-Cassiano@SebRoemer·
1/3: Whether you are in Toronto to attend #AAIC25 or visiting the birthplace of Neil Young and Drake – make sure to not miss our Symposium on “Network alterations and aberrant neuronal activity in Alzheimer's disease” on Wed., July 30, 2:00 PM
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Sebastian Roemer-Cassiano retweetledi
Nico Franzmeier
Nico Franzmeier@nfranzme·
Very happy to share our 2nd paper today, led by Lukas Frontzkowski: We developed a novel data driven reference region for PI-2620 PET tailored to assess 4R tauopathies, improving i) PSP vs. control separation and ii) PET associations with clinical scores doi.org/10.1007/s00259…
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Sebastian Roemer-Cassiano retweetledi
Nico Franzmeier
Nico Franzmeier@nfranzme·
Happy to share new work by Carla Palleis in @movedisorder, showing that brain networks route neurodegeneration patterns in PSP => This suggests that grey matter atrophy expands across connected brain regions, potentially following tau accumulation in PSP doi.org/10.1002/mds.30…
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Emma Coomans
Emma Coomans@EmmaCoomans·
So excited and honored to be invited to present the opening plenary at #AIC2025 this year in Toronto! 🧠 🙏 I would be very grateful if you could help me gather the most inspiring papers (including your own!) of the past year by completing this survey: alz.surveymonkey.com/r/923BTQK
Neuroimaging PIA@NeuroimagingPIA

🚨Calling all neuroimagers! Help @EmmaCoomans shape the opening plenary at #AIC2025 (Toronto, July 26th) "Accomplishments of the Past Year" and share the most impactful neuroimaging research from the past year via this brief survey (~5min) by May 30th. act.alz.org/site/R?i=eOejF…

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Sebastian Roemer-Cassiano retweetledi
Nico Franzmeier
Nico Franzmeier@nfranzme·
Excited to share our new work in Molecular Neurodegeneration, showing that α-synuclein co-pathology is common in Alzheimer’s and accelerates amyloid-related tau accumulation, supporting its role as a tau co-aggregation factor. doi.org/10.1186/s13024…
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Sebastian Roemer-Cassiano
Sebastian Roemer-Cassiano@SebRoemer·
Many thanks to the ADPD2025 committee for recognizing our work with @nfranzme on the effects of amyloid-induced hyperconnectivity on tau spreading! If you are enjoying a Gösser Radler and a Sacher Torte in Vienna, don't miss ADPD and my talk in Hall C at 10:00 on Wed 02.04.25
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Sebastian Roemer-Cassiano
Sebastian Roemer-Cassiano@SebRoemer·
Thanks to @NatRevNeurol for highlighting our latest work on amyloid-induced hyperconnectivity and how it promotes tau spread! Can’t wait for the next studies to describe this novel mechanism more in detail and maybe even tackle it therapeutically!? Exciting times
Nat Rev Neurology@NatRevNeurol

Amyloid-associated hyperconnectivity drives tau spread across connected brain regions in Alzheimer’s disease | Science Translational Medicine science.org/doi/10.1126/sc…

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Sebastian Roemer-Cassiano
Sebastian Roemer-Cassiano@SebRoemer·
So cool to finally see this project published in @Science TM. The idea came from clinical observation and ripened over many discussion with the best PI @nfranzme one can imagine. A new mechanism linking amyloid and tau, let’s explore it further and target it therapeutically!
Nico Franzmeier@nfranzme

Incredibly happy and proud to share our newest work in @ScienceTM showing that Aβ promotes neuronal hyperconnectivity, thereby driving tau spread across connected brain regions. Many thanks to to first authors @SebRoemer and Fabian Wagner! science.org/doi/10.1126/sc… Thread below

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Keşfet

@HAIconference @matbrendel @fislarissa @HeidiJacobsLab @nfranzme @_JakeVogel_ @ZShaoshi @csabaorban