Jia-Ren Lin

frontiersin.org/journals/bioin… A toolkit for generating virtual brightfield images of histological and immunohistochemical stains from multiplexed data with AI-based channel selection and image enhancement

🚨🚨Paper out!! 🚨🚨 Excited to share our work (Pre-cancer Atlas of High Grade Serous Ovarian Cancer (HGSOC)), now published in @CD_AACR! aacrjournals.org/cancerdiscover… What if I told you HGSOC often starts in the Fallopian Tube and progresses through precancerous lesions? 1/n 🧵👇

Systematic Benchmarking of High-Throughput Subcellular Spatial Transcriptomics Platforms biorxiv.org/content/10.110…

Now in @CD_AACR: Multimodal Spatial Profiling Reveals Immune Suppression & Microenvironment Remodeling in Fallopian Tube Precursors to High-Grade Serous Ovarian Carcinoma - by @TanjinaKader, @JiaRenLin, Clemens Hug, @ronny_drapkin, @SantagataMDPhD, et al. doi.org/10.1158/2159-8…

Join our Team at Harvard Medical School for an Outstanding Opportunity for Post-doctoral Training in #SpatialBiology Focusing on #Sarcomas - Biological Discovery, Translation Research, Clinical Trials. POST-DOCTORAL FELLOW IN TRANSLATIONAL CANCER RESEARCH - SARCOMA To apply, submit your: ·        CV ·        Cover letter highlighting your research interests and experience ·        Contact information for three references Email to Sandro Santagata, M.D., Ph.D. at sandro.santagata@gmail.com

A huge day for spatial omics of cancer, tracing the precise origin and evolution of 20 types of cancer, many in 3D, in ~2,000 individuals, with 12 publications @Nature @NatureCancer @NatureMedicine @naturemethods @CommsBio Collection nature.com/immersive/d428…

🚨 Great alternatives to BioRender are now available!! 📢 @NIAIDNews offers a collection of public figures and icons for everyone to use. Check it out at bioart.niaid.nih.gov

There is still time to register for this FREE VIRTUAL SYMPOSIUM on Spatial Biology organized by myself and my colleagues at @naturemethods @naturegenet @NatureBiotech and @nature! Check out the amazing line up!

systematic evaluation of computational methods for cell segmentation academic.oup.com/bib/article/25…

Wonderful to be selected for the Best of Cell 2023 - "Multiplexed 3D atlas of state transitions and immune interactions in colorectal cancer" - NCI Human Tumor Atlas Network #HTAN. @CellCellPress. Congratulations!!! to @JiaRenLin, Shu Wang, Shannon Coy, Yu-An Chen, Clarence Yapp, @madison_a_tyler, Maulik Nariya, @cody_heiser, @KenLauLab, and @sorger_peter, and all of the wonderful members of the HMS Laboratory of Systems Pharmacology (LSP) including Alyce Chen, Raquel Arias-Camison, Zoltan Maliga, Jeremy Muhlich, Juliann Tefft and more for all of their tireless efforts to make this innovative work possible. Very proud to be part of this team!!! @HiTSatHarvard, @BWHPathology, @MassGenBrigham, tissue-atlas.org Grateful for the strong support from @NCIHTAN, @Ludwig_Cancer, the Gray Foundation, the David Liposarcoma Research Initiative, @NCIsysbio, and more. Great way to close 2023! 🥂🎉🥳🍾🪩 More exciting work ahead in the New Year.

Open for submissions: Current advances of computational methods for tissue multiplexed imaging in research and diagnosis FrontBioinf frontiersin.org/researchtopic/…

What cannot be seen correctly in 2D visualizations of single-cell ‘omics data?: Cell Systems cell.com/cell-systems/f…

In the latest issue! Coordinated cancer chaos dlvr.it/ShKhz7

@sorger_peter @SantagataLab @KenLauLab @NCIHTAN @HiTSatHarvard Special thanks to @JuliannTefft who made a huge push on the final stage of this publication.

Thanks to all the co-authors @sorger_peter, @SantagataLab, Shu Wang, Shannon Coy,Yu-An Chen, Clarence Yapp, Madison Tyler, Maulik Nariya, @KenLauLab and Cody Heiser. Also thanks to all the people in @NCIHTAN and @HiTSatHarvard communities

Thrilled to shared our paper "Multiplexed 3D atlas of state transitions and immune interaction in colorectal cancer" sciencedirect.com/science/articl…

In this study, we explored the tissue-level organizations of different histopathological motifs, and spatial correlations of immune and tumor populations. Furthermore, we discussed the potential issues of spatial samples on quantifying different cell types.

Exciting times to be visualizing cancer pathology! It’s our honor to be developing new ways for talented researchers like @sorger_peter and team to continue making break-throughs in understanding, prevention and treatment! #cancerpathology #highplextissueimaging #cancerbiomarkers

Pretty neat, worth to try!! aquila.cheunglab.org

Harvard 40-patient colon cancer study finds novel spatial biomarkers most prognostic for tumor progression. Cites #RareCyte Orion data as uniquely able to support clinical studies by fast, high-fidelity multiplex IF + same section H&E whole-slide imaging. biorxiv.org/content/10.110…