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Joe Pelt
409 posts
Joe Pelt
@JoePelt
MD-PhD @ Tri-I Cornell, Landau lab. Building sequencing tech to study how age-related (epi)genomic changes cause cancer. Previous: U Oxford, FSU.
Katılım Temmuz 2010
901 Takip Edilen803 Takipçiler
Things I learned in March
Your habits become your life. Your life is defined by your habits. And then you die (no one is coming to change your habits for you.)
Adulthood brings more responsibility. It’s easy to feel heavy and bogged down by duties and tasks. But lightness + youthful positivity are still attainable
Working out 6-7 days per week feels way better than only 3-4 days per week.
Scrolling twitter evokes a dangerously unnatural wide range of emotions by exposing you to a dangerously wide range of content
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Joe Pelt retweetledi
Two things since ChatGPT dropped have felt like genuine ChatGPT-level moments: Claude Code and now this
Google DeepMind@GoogleDeepMind
Step inside Project Genie: our experimental research prototype that lets you create, edit, and explore virtual worlds. 🌎
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@kenbwork @BiotechMongoose How dare you gain deeper insight about a key biologic principle!
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@BiotechMongoose Interesting when scientists try to reduce wonder and curiosity to some form of intellectual olympics. This is a very deep idea and will spend many years trying to understand it. Happy you were able to in 3 weeks.
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"The deeper you dive"
No
Stop
You learn this in like week 3 of an undergrad devbio course.
Kenny Workman@kenbwork
The deeper you dive into dev bio, the more you notice the core molecular toolkit of morphogenesis is (1) remarkably conserved and (2) conducive to engineering. > Flatworms and jellyfish use largely the same transcription/paracrine factors as flies or even vertebrates > The ~36 major animal lineages encompass all 'body plans' seen in nature > Are at least 11 conserved Wnt genes across vertebrates with Wnt like genes in the *most basal of extant metazoans* Tissue, then entire organisms, will come from the gradual inference of what molecular cocktails induce what development trajectories when applied at the correct time and location. For medicine, agriculture, housing and consumer products. Limbs (and cities) might be grown one day. Cheering for Polyphron.
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Things I learned in 2025
90% of suffering is mental.
It’s easy to become a reader if you just start by reading 10 minutes per day.
Checking your phone multiple times per day is the key to having a distracted, fragmented mind. A new sense of flow is achieved when you put your phone away for extended periods.
It’s possible to produce great work without muscling every move.
Being stressed stresses others. Being calm calms others. Peace multiplies peace.
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Extremely honored to receive the AACR-EMD Serono Fellowship! Deeply grateful to @AACR & EMDSerono for such a great opportunity. Very thankful to @FaltasLab @WeillCornell @WCMDeptofMed @WCMGUcancer for unwavering support. Looking forward to contributing to bladder cancer research.
AACR@AACR
We congratulate Mohamed Osman, MD, a recipient of the inaugural 2025 AACR-EMD Serono “I’M IN” Oncodisparity Fellowship in Lung and Urothelial Cancers. We look forward to his findings on how ecDNA contributes to bladder cancer disparities in African American patients. @EMDSerono
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CAR T cell therapy can be life-saving, but like many other cancer therapies, can cause long-term “brain fog”. We discovered the cellular dysregulation underpinning this and a strategy to rescue the cellular and cognitive dysfunction in mice.
Eric Topol@EricTopol
New and concerning finding of brain inflammation and cognitive deficit from CAR T cell cancer immunotherapy but ability to mitigate it is also identified (in mouse model) cell.com/cell/fulltext/… @CellCellPress @michelle_monje @AnnaGeraghty2 @LehiAcosta
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I’m beyond grateful to share that I’ve matched into @WCMCPathology. Thank you to everyone who’s been part of this journey—couldn’t have done it without your support. Looking forward to the next chapter at this amazing program! #Match2025 #pathmatch2025
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@noampomsky Agreed. Creative ideas come from obsessively simulating new possibilities in your head until you hit silver, and then obsessively reiterating that silver idea until it becomes gold
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🚀 AI is changing software forever.
I asked Claude 3.7 Sonnet to build an iPhone app for visualizing protein interaction networks in AR—having zero experience in Swift or ARKit.
The result? Nearly 2,000 lines of functional code. 🤯
(1/🧵)
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1/ Delighted to share the published version of this work from brilliant #CancerNeuroscience post-doc @TaraBarronPhD detailing GABAergic neuron-to-glioma synapses in #DIPG/#DMG. 🧵
Open access link:
#Sec2" target="_blank" rel="nofollow noopener">nature.com/articles/s4158…
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@TischCancer @FrancoIzzo85 @ASH_hematology @IcahnMountSinai One of the greatest + smartest people I’ve met in my life… Congrats, @FrancoIzzo85!
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Congratulations to @FrancoIzzo85, recipient of @ASH_hematology Scholar Award.
hematology.org/newsroom/press…
@IcahnMountSinai
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@nwilliams030 Stops in to my apartment to warm up after hanging out with Rafa in Central Park. Rafa is old enough for legos and does creative destruction on the Lego Tie Fighter!
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My goal is that NYC living one big string of friends stopping in for a pastry I made on their way to work, or an espresso shot mid day on their walk around the neighborhood. Conversations at the bodega and grocery store with the cashiers and neighbors and security guards.
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“Good and evil both increase at compound interest... the little decisions you and I make every day are of such infinite importance. The smallest good act today is the capture of a strategic point from which, months later, you may go on to victories you never dreamed of."
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@LNuzhna Good scientists match appropriate technology to the right question.
Quick in vitro models often lack the complexity to answer certain questions. Lots of questions you can't answer with such experiments. Organoids make sense when additional complexity is needed.
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The version of the idiot index in bio is the ratio of [how much your experiment informs you about the final biology you are modeling] to [how hard it was to set it up].
Eg: Imo, organoid / organ-on-a-chip work has an unusually high idiot index. Not informs you about in vivo much better than a quick in vitro model, AND is very far from a quick, straightforward experiment run daily in every lab (aka requires specialized expertise and a lot of iteration to set it up). Seems absurd for any biotech company to ever screen anything in organoids.
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A commonly inherited genetic variant of human PCSK9 drives breast cancer metastasis and associates with reduced patient survival. @CellCellPress PCSK9 drives pro-metastatic genes by repressing LRP1. Anti-PCSK9 antibody has breast CA metastasis suppressive effects
🙏@RockefellerUniv @NCIsysbio @NCI @Lunduniversity Hess Family. sciencedirect.com/science/articl……tweetorial by amazing @wenbin_mei x.com/wenbin_mei/sta…
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