Juan A Perez-Bermejo

@james_t_webber @bulutkarslioglu not really for mouse ES cells. But @benoitbruneau's is a great lead.

Twitter colleagues, can you help me identify the most up-to-date cardiomyocyte differentiation protocol (of mouse ES cells)? Last time I did this was 10 years ago...

@KSerahSera @SarahJRockwood @Camille_Rosa15 Untap before draw and you get authorship

@Juan_PerBer @SarahJRockwood @Camille_Rosa15 we could mtg and recover the original order probably

Oh man @Juan_PerBer @SarahJRockwood @Camille_Rosa15 why didn't we do this!!

@gheimberg Came here looking for a picture of Roccapulco packed with salsa dancers but got quickly reminded whose Twitter account this is

Salsa bars are open for business. California is back, baby!

@DrewJCraig @Wizards_Help @xcver @MTG_Arena ha good point but no, I said I had 5 hours today (reasonable allotment for this type of event), not tonight or tomorrow morning when they are telling us to play now

@Juan_PerBer @Wizards_Help @xcver @MTG_Arena Saying you have real life time restraints and then saying you've spent 5 hours trying to play may seem contradictory to some lol

⚠️ Investigating: We are currently experiencing an issue with Magic: The Gathering Arena and are investigating. We will update you when we have more information to share. stspg.io/1v3x0c7zyv7n?u…

@Wizards_Help @xcver @MTG_Arena This seems to ignore people have lives and we might have planned to play during this window and not tomorrow morning because life. I have been trying for the last five (!) hours with no success whatsoever. only got to open my pool.

@xcver @MTG_Arena The Day 1 entry window is open to all for another 14 hours (until 3 am Pacific; noon your time Xcver) and matches are still possible for another 3 hours following that for existing courses.

@KarlKochanowski @exploratorium Always ahead of your time

@Juan_PerBer @exploratorium I saw it live some time ago, super cool exhibition!

We heard you like stem cells, so we plug a heart rate monitor into iPS-derived heart cells so you can come and synchronize them to your own heart rate (jumping jacks optional). A permanent interactive exhibit at the @exploratorium in San Francisco! (1/3)

@joadelas @GladstoneInst @exploratorium Thanks! It was still pretty fun to tell the children that maybe if the heart rate monitor didn't work on them it is because they are vampires.

@Juan_PerBer @GladstoneInst @exploratorium This is as interactive as science outreach gets. And much safer than those exploding bottles you like to show school children. Congratulations.

Preprint describing the exhibit design and results is now up on bioRxiv. biorxiv.org/content/10.110…

Cells respond in real time to changes in heart rate, and the results accurately match clinical-grade monitors. Interviews revealed the exhibit prompted curiosity for stem cells, electrophysiology, and heart health (but it was hard for them to realize cells were human!) (2/3)

@s3pm3p @ScienceMagazine @GladstoneInst @ScienceTM @ToddMcDevitt Supp Fig 6. We used the “common cold” HCoV’s. We didn’t have access to SARS-CoV or MERS, sadly. But there were reports of infection of myocardial tissue by the former back in the late 2000s

How can #COVID19 damage the heart? Using #iPSC-derived cells and patient samples, scientists at @GladstoneInst discover #SARSCoV2 disrupts structural genes and the morphology of infected heart muscle cells. @ScienceTM @ToddMcDevitt @Juan_PerBer fcld.ly/jqlig6x

@keveen2 @ScienceMagazine @GladstoneInst @ScienceTM @ToddMcDevitt Not a Twitter worm myself but you raised a good point - we were aware of this (although the rate for COVID-19 is higher than most, this could be biased). What motivated our study was how easily SARS-CoV-2 infected cardiomyocytes in the dish, which seemed to be rather unique. tx!

@ScienceMagazine @GladstoneInst @ScienceTM @ToddMcDevitt @Juan_PerBer Not unique to Covid heartandstroke.ca/articles/how-d…

How can #COVID19 damage the heart? Using #iPSC-derived cells + patient samples, @GladstoneInst scientists discovered #SARSCoV2 disrupts structural genes + morphology of infected heart muscle cells. @ToddMcDevitt @Juan_PerBer @ScienceTM stm.sciencemag.org/lookup/doi/10.…

Beautiful work leveraging the combination of iPS-CM, monocyte culture and hamster models to study #SARSCoV2 infection in the heart. Congratulations @virusninja @ChenShuibing and team! Looks like you didn't find virus stain in human autopsies. What do you make of this?

@EricTopol @MayoClinic The 3-4 clinical reports of #SARSCoV2 in heart have in common that patients died in acute phase. I wonder if these are exceptional cases, or if virus in heart is common in COVID19 but transitory and we only capture it in the acute phases (that would explain cardiac abnormalities)

A 35-year-old woman had sudden death from #COVID19. She had focal virus heart cell infection. @MayoClinic, led by Jay Schneider, w/iPSCs, showed virus spike protein-mediated membrane fusion and damage of heart muscle cells along w/ cell-to-cell spread researchsquare.com/article/rs-955…

I'm probably late to the game but this @NatureComms made me realize #SARSCoV2 virus in blood is quite common (27% hospitalized patients, 13% outpatients), setting up a clear route of infection of other organs. nature.com/articles/s4146…

@KarlKochanowski @munidiaries It was a low effort year - cash cow

@Juan_PerBer @munidiaries Awesome Juan! One of my favorite costumes of yours too :). Did you dress up this year?

That night I fulfilled a long doughy dream. Glad it lives on in the memory of the @munidiaries