Kate
969 posts


@MakisMedicine Wonder if it would help the inflammation of pericarditis? High doses of NSAIDS and colchicine are hard on the GI tract.
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NEW ARTICLE: RESEARCH - Ivermectin and AUTOIMMUNITY - How Ivermectin could help Autoimmune diseases - 2025 Paper by Iraqi researchers
2025 Sadeq et al - The immunomodulatory effect of Ivermectin on rat vasculitis model
Ivermectin is "immunomodulatory" - it modifies or regulates the immune system's response
Vasculitis means inflammation of the blood vessel walls. It can damage vessels, reduce blood flow, cause bleeding or clots, and harm organs. The immune system overreacts, releasing inflammatory chemicals, activating neutrophils, and producing antibodies that attack the body’s own tissues.
This study aimed to investigate immunomodulatory effects of IVERMECTIN on the rat vasculitis model.
This experimental animal study used 33 male Winstar rats divided into 5 groups:
Group I (Control): Healthy rats (no disease, no drug).
Group II (Disease / Vasculitis group): Rats given ovalbumin (from egg whites used to sensitize immune system) + LPS (a bacterial toxin) to trigger vasculitis.
Groups III–V (Ivermectin treatment groups): Rats pretreated with ivermectin daily for 7 days at three different doses (0.5, 1.0, or 1.5 mg/kg), then given the same ovalbumin + LPS to induce vasculitis.
They measured blood levels of inflammatory markers (IL-6, CRP, MPO-ANCA) and examined lung tissue under the microscope for TLR4 expression (a key inflammation trigger).
IL-6 (a pro-inflammatory signaling protein)
CRP (C-reactive protein, a marker of body-wide inflammation)
MPO-ANCA (antibodies linked to certain vasculitis that target neutrophils)
TLR4 (a receptor on cells that senses danger signals like bacterial toxins and kicks off inflammation)
RESULTS:
Group II (disease, no treatment) showed strong inflammation as expected:
Much higher IL-6, CRP, and MPO-ANCA in blood.
Strong TLR4 staining in lung tissue
(lots of inflammation signaling).
Groups III-V (IVERMECTIN) - All three ivermectin-pretreated groups had significantly lower levels of these markers compared to Group II
The reductions were clear even at the lowest dose (0.5 mg/kg), and higher doses generally looked better, though all worked well.
Microscope images of lung tissue confirmed less TLR4 expression in the ivermectin groups — the inflammation “alarm system” was quieter.
The authors conclude that IVERMECTIN has immunomodulatory (immune-calming) effects in this rat vasculitis model.
Ivermectin appears to:
Dampen the initial innate immune response (via TLR4).
Reduce production of key inflammatory signals (IL-6).
Lower harmful autoantibodies (MPO-ANCA).
Protect blood vessel and tissue integrity.
CONCLUSION:
The researchers suggest IVERMECTIN could potentially help protect against vasculitis or similar inflammatory conditions by turning down overactive immune responses without completely shutting down the immune system.
KEY POINTS…
IVERMECTIN could help auto-immune conditions by:
decreasing expression of TLR4 (TLR4 or Toll-like receptor 4 drives autoimmunity by bridging innate and adaptive immunity, causing chronic inflammation and tissue damage)
decreasing production of pro-inflammatory cytokines like IL-6
decreasing production of autoantibodies
If you have not heard about Ivermectin's immunomodulatory abilities from your doctor, your doctor is not reading recent medical literature.
It's ok. Most of them don't. 🤷♂️


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@DrKristieLeong @fmfclips @foundmyfitness Broccoli sprouts carry a high risk for bacterial contamination with Salmonella and E. Coli.
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I agree with all of the above. My only question is why take sulforaphane as a supplement when you can eat broccoli sprouts daily? Most sulforphane supplements are extracted under high heat and you don't get significant myrosinase. Without the myrosinase, which is abundant in broccoli sprouts, you might only convert 10% to 20% of the dose. In contrast, the whole plant provides the substrate, the catalyst, and the fiber matrix.
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8 supplement staples for @foundmyfitness:
• Vitamin D
• Omega-3s
• Multivitamin
• Magnesium
• Sulforaphane
• Creatine
• Ubiquinol
• Phytosomal curcumin
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In case you were wondering about any possible lowering of the temperature in this moment
NRCC@NRCC
Moments Ago: A visibly agitated Hakeem Jeffries says “I stand by” calling for “maximum warfare” against Republicans. “You can continue to criticize me for it, I don’t give a damn about your criticism!” Unhinged.
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We’re a long way from Peter Arnett these days….
Chris Cillizza@ChrisCillizza
"I'm not going to any more events where Trump is at them. I don't feel safe." --@chucktodd
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The new Huberman Lab episode is out: Male Roles, Obligations and Options for Building a Fulfilling Life | Scott Galloway (@profgalloway)
0:00 Scott Galloway
2:45 Mentoring Young Men
6:16 Positive Masculinity Defined
13:37 Sponsors: David & Wealthfront
16:33 Men & Goals, Role Models, Technology; Relationships
26:34 Elon Musk; Big Tech
31:53 Varying Role Models, Flaws; Criticism, Big Tech & Incendiary Content
43:33 Sponsor: AG1
44:57 Fear, Dating & Rejection, Relationship Dynamics
53:39 Social Media Impacts on Kids; Regulation
1:06:03 Phone, Dopamine & Pseudo-OCD; Solutions
1:14:03 Sponsor: Function
1:15:14 Naval Academy & Lifestyle Protocols, Mandatory National Service
1:23:08 Alcohol Phones & Professional Considerations
1:33:43 Drinking Age; Cannabis, THC
1:37:16 Sponsor: LMNT
1:38:36 Cannabis; Porn, Addiction
1:46:14 Anger; Testosterone; Aspirational Masculinity, Toxic Femininity
1:56:25 Advocating for Young Men, Economic Opportunity, Gerontocracy
2:04:43 Generation Gaps, Retirement, "Vampire" Generation
2:10:30 Bet on Unremarkable, Universities & Vocations; Gerontocracy
2:18:48 Aging; Paying it Forward & Male Mentorship
2:25:33 Seeking Mentors, Young Men; Acknowledgments
2:33:13 Zero-Cost Support, YouTube, Spotify & Apple Follow, Reviews & Feedback, Sponsors, Protocols Book, Social Media, Neural Network Newsletter
Includes paid partnerships.
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@DavidPerlmutter @DrDaleBredesen PS I live in the Boston area and have had two doctors refuse to test fasting insulin! I paid an online company to test Omega 3 Index and will over time determine which of the tests you describe can be done as well.
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Your brain’s immune cells can either protect you or work against you.
In this conversation with @DrDaleBredesen, we explore how microglia are shaped by metabolism, sleep, diet, and lifestyle.
Alzheimer’s prevention starts years before symptoms.
Watch here: youtu.be/zvRm0ppXlfY?si…

YouTube
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@DavidPerlmutter @DrDaleBredesen Such an empowering discussion. Thank you, Doctors, for the sharing your thoughts and research with us so that we may optimize our brain health. I’ve read your books and I am currently reading The Ageless Brain. Looking forward to Brain Defenders.
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@davidasinclair Thank you for this post which can be empowering for those living with blood cancer or a smouldering blood cancer.
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And more importantly: did your body actually tell you to stop, or did you assume you needed to?
one of the most common finding in my office is that patients have stopped doing things their bodies could still do, on the basis of assumptions that were never tested.
They basically narrowed preemptively.
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@DavidPerlmutter Spent most of of the day outside walking then sitting in the fresh air and sunlight. After a cold and snowy winter in New England, 58 degrees felt like a gift.
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@thegarybrecka Wood cutting boards cannot be sterilized and may harbor bacteria. What about stainless?
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If you want to reduce your exposure to microplastics, start here.
Your cutting board.
Every time you cut on plastic, tiny particles are ending up in your food. You won’t see it, but it adds up over time.
This was an easy switch for me: Plastic → wood.
Sometimes it’s the small, daily things that matter most.
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Get "The Cognitive Enhancement Blueprint"
Packed with Rhonda Patrick's specific protocols for boosting BDNF with exercise, omega-3s, and heat stress
9 pages
Totally free
Sign up here:
bdnfprotocols.com
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Consuming around 75 grams of added sugar is enough to temporarily drop your testosterone by ~25%
That’s about as much sugar as you'd get from a donut and a soda
Research shows this testosterone drop occurs within just 2 hours, driven in part by insulin spikes interfering with hormonal signaling
While the dip is temporary, regularly snacking on sugar-loaded, ultra-processed foods likely means frequent hormonal disruptions, impacting mood, energy, and muscle mass
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@GregoryMaysMD Why don’t doctors want to order fasting insulin tests? I had two refuse to order for me.
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@DrFrankLipman Makes me wonder if we can store our own stem cells in young adulthood for future use.
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Stem Cells From Younger People Can Help Older Adults Gain Their Mobility Back
ow.ly/w0NQ50Yq3ag
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