Kshitiz Lab

Our continued research connecting pregnancy and metastatic cancer was recently covered by Scientific American Magazine. @sciam #research #cancer #CancerResearch #biology #medicine #MedTwitter #biotech #STEM #StemEducation #ScienceTwitter scientificamerican.com/article/insigh…

These #cardiomyocytes are mature for their age! The @KshitizLab at @UConn used cardiac mimetic matrix to generate cardiomyocytes with adult-like characteristics and model pathological #hypertrophy. 🫀 @CellReports paper: bit.ly/3QDbffI Episode: bit.ly/3P8T8wN

And in the roundup: 1) Modeling polycystic kidney disease 🫘 @TTdevbio @USCStemCell 2) Generating mature myocytes ♥️ @KshitizLab @JunaidAfzal_etc 3) Tracking T cells in organoids 🔍 @_Hubrecht @NatureBiotech 4) MSCs in the aorta 🧫 @UNSWMedicine

@sciam Congratulations to @KshitizKz, Gunter Wagner, @YasirSuhail7, and the rest of the team members for such groundbreaking work and recognition. #research #cancer #CancerResearch #biology #medicine #MedTwitter #biotech #STEM #StemEducation #ScienceTwitter

Our continued research connecting pregnancy and metastatic cancer was recently covered by Scientific American Magazine. @sciam #research #cancer #CancerResearch #biology #medicine #MedTwitter #biotech #STEM #StemEducation #ScienceTwitter scientificamerican.com/article/insigh…

Our paper from July 2022 presents "rapid iPSC-CM maturation on surfaces mimicking native cardiac microenvironment" and "concurrent metabolic and redox maturation on cardiac mimetic matrix (CMM)" @JunaidAfzal_etc #research #medicine #biology #STEM #cells cell.com/cell-reports/f…

The cow in your body. The more cow (or if you prefer horses) like we are inside, the more it prevents cancer spread. #Cancer #CancerResearch #animalscience #animals #metastasis #research #Biology #MedTwitter #MedEd #medicine #nature #cow #horse #science mdpi.com/2072-6694/14/9…

@Sarah_E_Pierce @JeffreyGranja @WJGreenleaf @LabWinslow @RuiTang16 @HowardYChang This work elegantly demonstrates how the downstream effects of an individual driver mutation can change throughout #cancer development, with implications for stage-specific therapeutic resistance mechanisms and the gene regulatory underpinnings of metastatic evolution. #health

Metastasis is the leading cause of cancer-related deaths and enables cancer cells to compromise organ function by expanding in secondary sites. @Sarah_E_Pierce @JeffreyGranja @WJGreenleaf @LabWinslow @RuiTang16 @HowardYChang #cancer #research Source: pubmed.ncbi.nlm.nih.gov/34341533/

@Sarah_E_Pierce @JeffreyGranja @WJGreenleaf @LabWinslow @RuiTang16 @HowardYChang Scientists found that the tumor suppressor gene LKB1 is frequently inactivated and identify LKB1 as a master regulator of chromatin accessibility and pro-metastasis factor. #ScienceTwitter #CancerResearch #MedTwitter #educational #stem #regeneration #health #laboratory #biotech

Developed LATS inhibitors that effectively suppress the expression of ESR1, providing new potential therapeutic targets for ER+ breast cancer, particularly those with hormone therapy-resistant ESR1 mutations. #research #cancer #biology #science #STEM #STEMeducation #education

Drugs targeting advanced breast cancers associated with mutant ERα represent a major unmet medical need. @SilvioGutkind #stroma #tumor #evolutionarymedicine #systemsbiology #cancer #medicine #MedTwitter #researchpaper #science #health #data source: nature.com/articles/s4146…

@SilvioGutkind The authors delineated the mechanism of ESR1 transcriptional repression by the LATS-YAP-TEAD-VGLL3 axis. #ScienceTwitter #CancerResearch #MedTwitter #educational #facts #study #stem #regeneration #health #laboratory #biotech #cancer #fibroblast #biology #nature #breastcancer

So an organ can be predisposed to get cancer by inflammation, or bad repair. #ScienceTwitter #CancerResearch #MedTwitter #educational #facts #study #stem #regeneration #health #laboratory #evolutionarymedicine #cancer #fibroblast #inflammation #repair #tissuerepair

Tissue repair and cancer are linked. @thecrick @IMalanchi @ScienceDaily #stroma #fibroblast #cancerenvironment #tumor #evolutionarymedicine #systemsbiology #inflammation #cancer #medicine #MedTwitter #researchpaper #science #health #data Source: sciencedaily.com/releases/2022/…

Scientists at Francis and Crick Institute found that the relationship between immune response and cancer is very complex. And it is their communication that can make cancer spread. @thecrick @IMalanchi @ScienceDaily #cancer #biology #technology #healthcare #ScienceTwitter

Cancer is not merely mutations getting accumulated. They can arise because of the "wrong repair" of healthy tissue. Finally, fibroblasts and inflammation are playing a central role in cancer. #stroma #fibroblast #cancer #tumor #medicine #biology #research

Our paper connecting pregnancy to cancer malignancy is out in PNAS. The paper details how pregnancy has evolved in mammals with direct effect on cancer metastasis in humans. pnas.org/content/119/6/…