Lisa

Nature research paper: Diet–microbiome synergy underlies obesity-associated immunotherapy efficacy go.nature.com/4eRKfI9

Happy to share our new preprint from @RutterLab. To understand how genes are controlled, we developed a method we call TRoUT-FISH, using CRISPR + RNA-FISH. We found that glycolytic gene expression is fine-tuned by lineage specifying transcription factors. biorxiv.org/content/10.648…

Our new preprint, why does Rapamycin increase female lifespan more than male? Building Rapamycin fly cell atlas, we revealed a new aging state, called Convergent Aging Trajectory (CAT). It helps understand why aging and rapa impact male/female differently. share.google/3Xsbch5ThsqLeA…

Host metabolism can produce many indoles and phenols independently of the microbiome dlvr.it/TTBQfH

Could the way your lung cells age affect #LungCancer risk? A new open-access Nature Medicine study @daisyding_ suggests lungs carry a “biological age” of their own. Faster-ageing lung cells were linked to higher risk, beyond smoking alone. nature.com/articles/s4159… #LCSM

Pan-cancer spatial atlas of tertiary lymphoid structures science.org/doi/10.1126/sc… @ScienceMagazine @IamLinghua @UTMDAnderson @kyungserkcho

How does oxygen sensing shape alveolar #macrophage (AM) identity? In our new @CellReports HIF-1α and HIF-2α play distinct, non-redundant roles in AM maturation & function A #metabolic split that defines macrophage biology in the lung. OPEN: sciencedirect.com/science/articl… @CNIC_CARDIO

In vivo single-cell ribosome profiling reveals cell-type-specific translational programs during aging cell.com/molecular-cell…

Tumor-immune-neural circuit disrupts energy homeostasis in cancer cachexia cell.com/cancer-cell/fu…

I'm officially an expert in failing! I was asked to give the opening keynote today for a @CRUKCamCentre conference, speaking on the topic "Failing in Science"

Incredible new paper from Max Krummel's group showing that macrophages sample cellular content from living cells to present to T cells! nature.com/articles/s4158…

Nature research paper: Early fibrotic niches establish tumour-permissive microenvironments go.nature.com/4eyjatK

CAR-neutrophils produced in vivo to treat glioma @natBME @PurdueResearch @penn_state nature.com/articles/s4155…

Do not miss the opportunity to join a great community and catch up on the latest developments in Cancer Metabolism. Terrific lineup + many many slots for selected speakers. Sponsored Travel Grants available. REGISTRATIONS ARE OPEN.

New research in Nature suggests cancer cells can learn to resist therapy, not by mutating, but by reprogramming themselves. In #lungcancer, resistance to targeted treatments is a significant challenge. Understanding how this happens is an important step in the search for better treatment 🔗 doi.org/10.1038/s41586… #LCSM

We have an exciting new story out at @ScienceMagazine's Science Immunology! It is about using #AAV cytokine delivery to change the lung environment. We can boost #lung #Tregs or delivery anti-inflammatory #cytokines, preventing fatal respiratory collapse science.org/doi/10.1126/sc…

Our new work by @shanshanliu1218 and @gadmark addresses a fundamental question: how does ER maintain its unique oxidizing environment, while rest of the cell is reducing? Here, we identify SLC33A1 as the major ER GSSG exporter in mammalian cells. nature.com/articles/s4155…

Towards Spatial Medicine for individualized cancer immunotherapy @SciImmunology "The convergence of spatial biology platforms, single-cell immune profiling, and machine learning is positioning the community to decode how T cell immunity is spatially organized in human tissues and to exploit that organization therapeutically" science.org/doi/10.1126/sc… science.org/doi/epdf/10.11…

🚨Paper alert🚨 Very excited to share our manuscript, published today in @ImmunityCP, where we describe how ‘Nonsense-mediated mRNA decay inhibition reshapes the cancer immunopeptidome’. (1/16) cell.com/immunity/fullt…

Exposed phosphatidylserine is an inhibitory molecule in T cell exhaustion @Nature @EmoryUniversity @rafiahmed_lab nature.com/articles/s4158…