IndyFix

Here's a Table summarizing the personalized vaccines that rev up the immune system vs refractory cancers. Another one vs metastatic melanoma (with ~50% cure rate at 5 years) will be out soon.

BioStack (@getbiostack) builds simulation environments where healthcare AI models practice on real clinical data. Messy records, lab tests, notes, outcomes unfolding over months— BioStack turns that into a post-training loop: data, evals, rewards, benchmarks. They've grown from six figures to seven figures in revenue in just the last few weeks. Congrats on the launch, @sanatmishra7 & @patwa_parth! ycombinator.com/launches/QUp-b…

Dylan Harper: 20 years old, 6'5", 215lbs, 6'11 wingspan, 2nd pick, potential star but needs to clean up efficiency Stephon Castle: 21 years old, 6'6", 215lbs, 6'9" wingspan, 4th pick, potential star but needs to clean up efficiency Wemby: 22 years old, 7'4", 240lbs, 8'0" wingspan LOL, 1st pick, generational superstar Devin Vassell: 25 years old, 6'5", 200lbs, 6'10" wingspan, 11th pick, strong 4th option, fits great and knows the system but overpaid and replaceable Julian Champagnie: 24 years old, 6'7", 220lbs, 6'10" wingspan, un-freaking-drafted, perfect in his role, practically free of charge Carter Bryant: 20 years old, 6'6", 220lbs, 7'0" wingspan, 14th pick, not much of a rookie year but could blossom into a two-way talent under the Spurs system Keldon Johnson: 26 years old, 6'5", 220lbs, 6'9" wingspan, 29th pick, probably not a championship-caliber player, overpriced one-way player who should eventually be replaced Harrison Barnes: Expiring contract, probably moving on judging by lack of usage in the playoffs (probably a mistake to use Bryant more at his age) Luke Kornet: 30 years old, 7'1", 250lbs, 7'1" wingspan, undrafted, perfect backup center, can plug into starting lineup (20-5 when he started this season), signed for years to come for great value I didn't even mention De'Aaron Fox, who I think needs to be traded because he costs too much, they'll have to use that money to lock in their young stars, and he is holding Harper back from starting. Trade for a PF who is better than Champagnie, bolster bench by bringing Champagnie off the bench Plumlee/Olynyk/Biyombo/Waters as 3rd string vets. It took them a long time, but the Spurs did a hell of a job building a team that will dominate for the next 10-15 years with room for improvement. They have great two-way talent and underrated two-way players who aren't undersized, surrounding a generational talent in Wemby. I look at this team building, and all I can do is shake my head at how disgustingly awful the Warriors organization has been in comparison.

Presented at #EASCongress2026: Vafai and colleagues report reductions in PCSK9 and LDL cholesterol levels and no dose-limiting toxic effects in persons with hypercholesterolemia treated with VERVE-102, a base editor targeting PCSK9. Full study results: nej.md/3QXnXeG @EASCongress

Finally, the long-awaited day has arrived!❤️ My husband has just received his first subcutaneous Anktiva injection. After such a challenging and uncertain time, this moment feels like a true gift and a powerful step forward. We are incredibly grateful to @DrPatrick and the entire ImmunityBio team for their compassion and for making this possible. My husband may well be the first EU citizen to receive Anktiva off-label, and we feel deeply humbled by that. We believe Anktiva deserves to reach patients worldwide so many more lives can be saved. In the meantime, my husband has already begun reacting to the first shot. We are monitoring everything closely and will keep you updated with any developments. We feel so blessed and remain full of hope for a wonderful outcome. Thank you all for your continued prayers and support, they mean more than you know🙏🏻 @ImmunityBio @LoriMills4CA42 @bullishbruk @ChiayuChenMD @richadcock @Av8rLady @CarnivoreKen @CFSCentral @Brandon_r_clark @RobertKennedyJr @US_FDA

Eli Lilly has done it. They've gone and made what seems to be a powerful, permanent gene therapy for LDL cholesterol. That means they'll be able to effectively prevent most heart disease with a single infusion!

I wrote about the remarkable proliferation of cancer immunotherapies, and what's in store erictopol.substack.com/p/the-remarkab…

The ramp up of cancer immunotherapy is remarkable. Now we're seeing vaccines achieve some cures or remissions in the most refractory cancers: pancreatic, melanoma, glioblastoma, renal, triple-negative breast cancer. ✓ out the new Ground Truths (link in profile)

As predicted in our Nant Cancer vaccine patent. Most excited to see the readout of the Lynch Syndrome trial to prevent cancer. 2 year follow up coming by next year. NK cell stimulation happening so far.

@BGatesIsaPyscho can someone change the background music to hall and oats?

🚨🇺🇸 The American White House just dropped the clearest clip of a UFO ever & nobody even gives a shit.

After reflecting deeply on this governance process, a few things are clearer to me than ever. Cardano is alive. The community is engaged. And that matters more than any single vote. But this process has shown me something important: Cardano's governance is real. You are not passive holders. You are owners. That is exactly what we built this for. It has also reminded me that when Cardano has needed it most, the Pentad delivered. IOG, EMURGO, the Cardano Foundation, Midnight Foundation, and Intersect have proven they can coordinate and bring critical integrations to life when the ecosystem needed it. That coordination layer matters now more than ever. So let me show up the way I should. I will be in Singapore for the Cardano Summit and I will be on stage. I am also personally committing to partially top up our Token2049 sponsorship to Title level. Being on that main stage is where Cardano and Midnight need to be heard. To the Pentad, I am inviting all of you to sit down and have a real conversation about the future of governance and how we formalise this coordination going forward. I am 100% focused on Cardano and Midnight. Always have been. Let me prove it. #strongertogether

@TulsiGabbard @TheUfoJoe @ODNIgov Tulsi, from one caregiver to another 💙🙏

I am deeply grateful for the trust President Trump placed in me and for the opportunity to lead @ODNIgov for the last year and a half. Unfortunately, I must submit my resignation, effective June 30, 2026. My husband, Abraham, has recently been diagnosed with an extremely rare form of bone cancer. He faces major challenges in the coming weeks and months. At this time, I must step away from public service to be by his side and fully support him through this battle.

@sama Breast Cancer. Breast Cancer. Breast Cancer. 🎀🎀🎀

what problem do you most hope AI will solve in the future? maybe we can help!

@JeffBezos Jeff. This is starting to sound a little like "I'm running for office" rhetoric 😉

Yes, the United States has the most progressive tax system in the world. The top 1% pay 40% of taxes, the bottom 50% pay 3% of taxes. We can make it even more progressive by zeroing out taxes on the bottom half. It’s a small amount of the total tax revenue but very meaningful to people in this group.

@rand_longevity Give someone you love a hug. Let it sink in. Feel it in your chest.

morning non negotiables for longevity: - sunlight before 8 - 15 minute walk - first meal protein - no phone until sun - delay coffee an hour anything else?

@TheProjectUnity My weekends kinda filled up but I'll do it if no one else can

Who speaks for Earth if Aliens arrive?

Two weeks ago, watching Agnessa Pedersen mind control a drone in real time, was one of the most moving moments in my career. Agnessa is a rare and wondrous human working towards a wild future.

SpaceX confirmed in their IPO filing that they still plan to offer point-to-point terrestrial travel on Earth using Starship It will enable passengers to fly anywhere in the world in about 30 minutes or less on Starship. • Los Angeles to New York: 5h 25m → 25 min • Bangkok to Dubai: 6h 25m → 27 min • Tokyo to Singapore: 7h 10m → 28 min • London to New York: 7h 55m → 29 min • New York to Paris: 7h 20m → 30 min • Sydney to Singapore: 8h 20m → 31 min Get ready, the future is wild.

I've spent decades studying exponential tech, and this longevity report is one of the most important I've done.  My 2026–2035 Longevity Metatrends Report covers the breakthroughs that will redefine healthspan, performance, and the meaning of aging. Read it here: metatrendsreport.com/longevity

@ycombinator @Panacea_Bio @Jeffliu6068Liu

Getting FDA approval is slow and very expensive. @Panacea_Bio hires the best FDA regulatory consultants in the industry, and pairs them with their AI platform, to deliver the fastest and lowest-cost pathway to FDA approval for Biotechs and MedTechs. ycombinator.com/launches/QPN-p…