Luis I. Prieto

I am thrilled to share our latest study just published in @Cancer_Cell! We found that senescent cells, specifically senescent macrophages promote tumor growth by adjusting the local microenvironment. cell.com/cancer-cell/fu…

Why some lung tumors respond well to immunotherapy. newsnetwork.mayoclinic.org/discussion/may…

Very excited to share new work led by the Fields lab with our team contributing to this exciting discovery. This study shows that senescent tumor cells actively induce the formation of tertiary lymphoid structures (TLS) in PRKCi-deficient lung adenocarcinoma.

Protein kinase Cι dictates tumor trajectory, cell plasticity, and immune surveillance in lung adenocarcinoma dlvr.it/TPTtj9

ICYMI 🚨 In this month's #Focus issue on #AgeingandCancer, de Magalhães explores the evolutionary relationship between cancer & ageing, proposing that the need to minimize cancer risk early in life may contribute to tissue degeneration later. 📖 👇 bit.ly/49UYjyi

ICYMI 🚨 In this month's #Focus issue on #AgeingandCancer, McAllister & colleagues discuss recent insights derived from age-resolved immunoprofiling of the TME and how ageing haematopoiesis affects immune cells and cancer progression. #REVIEW 📖 👇 bit.ly/43ptEFD

Our new perspective piece in @NatureAging from lab of @MiriamMerad @SinaiImmunol highlights the fundamental role for aging-related changes to resident tissue macs and myelopoiesis in both healthy aging and in cancer: nature.com/articles/s4358…

🎉 We’re thrilled to present our August issue, which includes a Focus on immune aging! 🎉Here, you’ll find a series of reviews and opinion pieces on recent advances in immune aging research nature.com/nataging/volum… 🎨by Alex Whitworth

NEW content online! Ageing, immune fitness and cancer bit.ly/3JdVu0c

🫁 Tumour–microenvironment crosstalk in #NSCLC drives resistance, metastasis, and outcomes. Understanding spatial niches, inflammation, and immune evasion can reshape treatment strategies. 📖 @NatRevClinOncol 👉 doi.org/10.1038/s41571… #CánCare #immunotherapy #biomarkers #lcsm

#Review 🚨 Henry & DeGregori discuss models and methods used to study the connection between ageing and cancer, advocating advocating for the wider adoption of age-appropriate models of cancer to improve clinical translation 📖⬇️ bit.ly/4eQqoaw @CUSystem

While progress has been made in treating #NSCLC, patients would further benefit from earlier detection & interception. Here, Spira & colleagues explore advances in identifying premalignant lesions, & devise approaches for stratification + interventions. bit.ly/4brKS7N

Everything everywhere all at once: Unraveling the waves of aging dlvr.it/TJ0JMD

Nature research paper: Neutralizing GDF-15 can overcome anti-PD-1 and anti-PD-L1 resistance in solid tumours go.nature.com/3VAtRSa

Myeloid effector cells in cancer dlvr.it/TGkhFv

NEW content online! Defining precancer: a grand challenge for the cancer community go.nature.com/3XH0wWo

Registration open for this meeting for a bit longer. A few spots left sbpdiscovery.org/calendar/molec… Submit an Abstract and present a Short Talk or Poster. This is a small meeting, so a great networking opportunity w/ great speakers. Please circulate.

Thank you everyone for joining us at our first Thursday seminar last week! Big thanks to Dr. Prieto @LuisIPrieto1 for sharing his research on Cancer and senescent cells. We were also pleased to introduce the new team at MRFA. What topics would you like to hear about next Month?

Fantastic work from @naritalab ! Many congratulations to @adelynechan, Masashi and all involved. nature.com/articles/s4158…

Online now!✨RESEARCH: @JPCastro_Aging, Shindyapina et al explore how aging promotes B-cell lymphoma in mice, identifying a population of age-associated clonal B cells that drive malignancy nature.com/articles/s4358… rdcu.be/dQmfa

🚨📄On our new publication in @ScienceAdvances, @emilynorton295 uses #Cell_Specific_Proteomics to uncover how cathepsin B drives #GBM malignancy near the #SVZ and induces #Neural_Stem_Cells #senescence This breakthrough offers new insight for #GBM science.org/doi/full/10.11…