Manuela Tan

@flynorse Our flight from OSL to LAX was cancelled with no notification email or message. The flight is in just under 3 weeks and we have not been offered a solution. We have to arrange other flights and rearrange accommodation. Please get in contact

Happy to share our new preprint on a GBA1 mutation classification database that we generated, hopefully it will be useful for researchers, clinicians and pharma companies. This work was done in collaboration with @cornelisblauw and his team at the NIH. medrxiv.org/content/10.110…

Learn how to conduct PD progression GWAS, Haplotype, Burden & CNV analyses, fine-mapping, heritability, cross-trait genetic correlations, MR and more with top instructors 🤩@ManuelaMXTan @BrolinKajsa @ben_m_jacobs Julie Lake. Great team work @PerinanTeresa @predictPD @sumitdey94

@Ed_Jabbari @CurePSP @MDC_IoN_UCL @huwmorris @PSPAssociation @mrcppu Congratulations Ed!! 🎉🎉

Delighted to receive a Venture Grant from @CurePSP to further explore LRRK2’s role as a determinant of disease progression+therapeutic target in tauopathies! Will be based @MDC_IoN_UCL - collaboration with @huwmorris @PSPAssociation and @mrcppu (E.Sammler+D.Alessi). Details soon!

@HirotakaIwaki @PDandHDLab @foltynie + many others not on Twitter or I may have missed (apologies)

This was a massive effort and would not have been possible without all the participants who took part in these research studies, as well as all the people who contributed data and expertise @huwmorris @LassePihlstrm @MaryamShoai @Ed_Jabbari @reynolds_regina @cornelisblauw ...

We did a GWAS to identify genetic variants that influence #Parkinsons disease progression and mortality. Check out the preprint here! medrxiv.org/content/10.110…

@smead2 @drpatricklewis Thank you!

@ManuelaMXTan @drpatricklewis This is a lovely paper well done

Our review of Mendelian randomization and colocalization "Combining evidence from Mendelian randomization and colocalization: Review and comparison of approaches" is now online at AJHG: authors.elsevier.com/a/1ey76geX2WXN. Summary follows!

For 4 years me and @ManuelaMXTan spent most of our days/nights genotyping samples in the 9th floor labs @UCLIoN or swearing at R and GenomeStudio in the office at Russell Square House. I’m glad we made it and got to celebrate together today!

Announcing 3-year bioinformatic postdoc position in our group at @ResearchNeurOUS to work on genomics in #Parkinson's disease and other neurodegenerative disorders! Funded by @helsesorost. Ad here, and contact me for info: 2411.webcruiter.no/Main2/Recruit/… @pdgenetics

Check out our Primer (out today!) for how to carry out genome wide association studies, including best practices, ethical considerations and future directions in the field. @euffelmann @hilsomartin @DPosthu @sangerinstitute @hilsomartin @qinqin_huang go.nature.com/3zkoF81

🧬August Methods Meeting Please join us for our expert led presentation by @dougthespeed discussing methods for GWAS data, with a focus on prediction of complex traits. 📅Tuesday 10th August 3pm. For further information and registration for the event: eventbrite.co.uk/e/london-genet…

(1/7) Manuscript reviewing tips -Don't review beyond expertise: it can be tempting to accept an invitation from a reputed journal but don't review beyond your expertise as it can be harmful if you miss something which has a significant influence on the results. @AcademicChatter

"How to cover letter"; a brief thread from a scientific editor's perspective Yes, in brief editors do read cover letters although like myself, most pay far less attention than to the abstract and main elements of the paper! First, a few "do's"

@monicadiezf1 @nachogenePD @ycompta Congratulations!!🎉🥳

You can call me Dr!! So thankful for this journey and so happy to have share it with awesome people!! Also special thanks to my excellent board committee @nachogenePD @ycompta and Dr Mario Ezquerra #phddone

Exciting news everyone...we are back! Join us this Wed @ 2pm to hear from @ManuelaMXTan, @UCL, on genetic variants associated with progression, and @ViolaVolpato, @cardiffuni @UKDRI on cell-specific pathways associated with genetic risk. Register: parkinsons-org-uk.zoom.us/webinar/regist…

We’re excited to launch the first training module from #GP2Research: Beginner Bioinformatics for #Parkinsons #Genetics. Aimed at researchers and clinicians, the course provides a basic introduction to bioinformatics and its application in #PD. parkinsonsroadmap.org/gp2/bioinforma…

How to revise: As an editor and author I have seen many revised papers return to journals. Given effort, most go well (ie step toward acceptance). Some go pear-shaped. I’ve slowly improved and have an approach known by my group as the ‘Breakspear method”. Here is its essence

Really excited to share our work on the genetics of PD progression. We used a new PCA approach to identify variants associated with motor and cognitive progression. @huwmorris medrxiv.org/content/10.110…