Mhurz ⬡

@binneystreetbio @bradloncar Ocrevus has been an absolute miracle for me. Genentech may not be the same as they were but they are still massively succeeding at impacting patients lives.

@bradloncar Columvi, Ocrevus, Polivy…have they really been much less productive than other big pharma R&D

The decline of Genentech over the last 10+ years has been sad to watch.

@voidshapes @AtomicAICo @SeyoneC @jajoosam @CadeGordonML @aakarshv1 We should talk about drugging RNA sometime 😀

@YSPTSPS IYKYK

I have the same name at the other place because the pol ii ctd will always be my first love ysptsps 💙 ☁️

@wmcarterelliott @ben__widodo @EM_RESUS Any paper with EGCG is actually less reliable than a newspaper article on bat boy.

@ben__widodo @EM_RESUS No. That's a newspaper article. Do you know the difference between a newspaper article and a Peer-reviewed/Journal-Published Science Paper? One of these is a Science Paper, the other is a magazine article. Can you guess which is which? 🙄

When a critical patient develops a sudden and strong urge to move their bowels, they are about to code until proven otherwise. Trust me on this one.

@antmccrossan are you commenting the Vuelta this year? Which network?

@WilsonLab2 Just PyMol visualization?

Coming soon...the antibiotic tetracycline on the ribosome at 1.8 Å resolution

@ClementYChow @eperlste Not by choice. Lived in SF for a decade, now in Boston. Nigh impossible to find a good burrito here.

@eperlste Number of burritos consumed

Trying to put my finger on the differences between the nerd energy in Boston vs SF…

@Amine_Khadiir @Figensport That would be norovirus. Every parent knows this night (and that they will get it soon after).

@MarkELindsay @DrCanuckMD I knew someone like this... In an adjacent graduate program... At UCSF

@shycollie Dichloromethane or toluene.

This probably comes up a lot on medtwitter but I was dumb today and put the pen in wrong, it’s Mont Blanc rollerball ink, I can’t even get it off my hands. What’s the best solvent? Google says everything from hairspray to WD40 and lots of stuff in between

@grantbfs @RyanMaue I'm not sure you understand how scalability works... That big power plant is much more efficient.

Half of all gas stoves on the market would be banned by new DOE regulations to combat climate change. A closer reading of the proposed rule puts the number closer to 96% of gas stoves would no longer meet new standards. The Biden admin has floated a complete ban on all gas-powered cooking appliances in an effort to reduce home carbon footprints. eenews.net/articles/doe-r…

@LifeSciVC @ZoeBarryCEO The waffle huts are torture though.

@ZoeBarryCEO Definitely Loon in NH. 😃 Nothing more exhilarating than flying down an icy slope of man-made's finest snow... plus the crowd is very cool. #SkiTheEast #SkiNH

Building my company has really negatively impacted my skiing agenda. If I got to plan one ski trip for the year, which mountain should I visit? #shred #skibunny #apres #ski

@crpickering @JSheltzer Multiple people were actively publishing on prions at the time and the hypothesis was beginning accepted. In the original paper there isn't even data from Prusiner at that point in time. He should have shared the Nobel with others.

@JSheltzer Interesting question. I don't know all of the history but a few possibilities come to mind. Prions by Prusiner PCR by Mullis Microarrays by Brown H. pylori in ulcers by Warren/Marshal (working together)

Many big scientific discoveries are races. Consider splicing - co-discovered by Sharp & Roberts, with many others close behind. Erase one and the discovery still happens within months. What breaks this pattern? “If not for X, it would have been decades before Y was discovered.”

@KRHornberger @DrLCsquare The level of rigor in industry is also significantly higher, as the entire company can be riding on your experiments.

@DrLCsquare Funny thing is, I feel like going to industry was finding my intellectual home. The applied nature of pharma and the interdisciplinary environment appealed very strongly to me in a way that academia never did. Everyone sees things differently I guess.

Leaving academia was like losing our intellectual home —> interesting read. I haven’t felt this as much myself. science.org/content/articl…

@pickardlifts @maximum We've never seen different tier pieces drop at once. For us we get two drops, and it's always the same. I don't know if it's intended or a bug but it feels bad.

@maximum I did a full clear normal today. Every tier peice that dropped was the same type, zenyth I think. Bad luck or not,in a loot system where that is even possible the catalyst should have been released week 1.

Catalyst is clearly weeks or a month too late. I don’t know what else can be said at this point it was directly asked in like 4 interviews and this is exactly the same timeline of season 3(which was also disliked). Hopefully they change direction with that.

@adamfeuerstein That's a shame. I used to love hitting up that place after a night out.

This makes me so sad.

@CraigMCrews Cool concept! Reminds me of this: pubs.acs.org/doi/abs/10.102…

RIPTACs selectively kill cells by differentially accumulating an antiproliferative agent using an Induced Protein:Protein interaction (PPI) to a differentially expressed protein.

Ever try to drug an oncoprotein driver only to have the tumor lose its dependency on it and become drug resistant? Introducing RIPTACs (Regulated Induced Proximity Targeting Chimeras) in collaboration with Halda Therapeutics.

@dragon38073853 Please keep going! These interesting and exciting new discoveries are a jewel when they pop up on my feed.

@NicholasFlorko Looks interesting! Have you considered a podcast? Hard to find time to read some days but lots of time driving on the commute..

STAT just published an eight part series I’ve worked on for the last two years. I’ll have more to say in the AM. But for now, ill just say please read it, and that I’m so thankful to the folks who shared their stories, and all my great colleagues here. statnews.com/death-sentence/

@AlanPlotzker @MarkELindsay I have one too that I got for the same price. Last time I checked their value had skyrocketed.

@MarkELindsay Nice. I still have a bottle of Yamazaki 12 from med school when it was like $40 a bottle. Will probably bring home some form or other from my current Japan trip