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Pat Sheehan
319 posts
Pat Sheehan
@patwsheehan
Postdoc in Dori Schafer's lab at UMass studying complement in the CNS. Former Grad student in Erik Musiek's lab at WashU.
St Louis, MO Katılım Ocak 2019
399 Takip Edilen383 Takipçiler
Pat Sheehan retweetledi
Fan comic for a great new paper from @ErikMusiek + collaborators on circadian gene expression in Alzheimer's models.
tl;dr: *when* you collect your tissue changes the story you get.
nature.com/articles/s4159…
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Pat Sheehan retweetledi
Characterization of the circadian translatomes of astrocytes and microglia in mouse cortex in the setting of amyloid pathology or aging, revealing cell and disease-specific circadian reprogramming of neurodegeneration-related pathways
@ErikMusiek @johnthefryer @patwsheehan @carpeRibosomam
nature.com/articles/s4159…
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Pat Sheehan retweetledi
A nice article in @washumedicine about our recent paper:
medicine.washu.edu/news/alzheimer…
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Congrats @patwsheehan and @ErikMusiek et al! Beautiful work! So happy this is out. Remember (glia) people, timing matters!
Erik Musiek@ErikMusiek
Our glial circadian atlas in AD and aging mice is now out in @NatureNeuro! Congrats to @patwsheehan for incredible work and to our collaborators @johnthefryer, @CarpeRibosomam, @darshan1s, Ron Anafi, and the team. @johnthefryer and I started this in 2019! nature.com/articles/s4159…
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@asharma313 Thanks so much Ashish! Your experiments were key for the paper!
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Incredible work led by @patwsheehan — and the Shiny app even lets you check whether your favorite gene shows rhythmic expression. So cool!
Erik Musiek@ErikMusiek
Our glial circadian atlas in AD and aging mice is now out in @NatureNeuro! Congrats to @patwsheehan for incredible work and to our collaborators @johnthefryer, @CarpeRibosomam, @darshan1s, Ron Anafi, and the team. @johnthefryer and I started this in 2019! nature.com/articles/s4159…
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Here is a link to the previous tweetorial of the paper: x.com/patwsheehan/st…
Here is a link to our Glial circadian transcriptome website: musieklab.shinyapps.io/Glial_Circadia…
And here is a link to the paper!
nature.com/articles/s4159…
Pat Sheehan@patwsheehan
My final paper from my PhD with @ErikMusiek is now on biorxiv! We asked if microglia and astrocytes have the ability to change which genes are expressed in rhythmic manner during Alzheimer's pathology and during normal aging. biorxiv.org/content/10.110…
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ROS in vitro. We also show some evidence that this circadian reprogramming could be happening in humans with Alzheimer's disease. We built a website so that anyone can query the data. We hope that it helps inform future experiments in the field!
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Super happy to see my last paper from the Musiek Lab @ErikMusiek in its final form. We previously described the paper when we added it on biorxiv (also posted below). Essentially, we profiled the circadian translatome of astrocytes and microglia in vivo in healthy, aged, and mice
Erik Musiek@ErikMusiek
Our glial circadian atlas in AD and aging mice is now out in @NatureNeuro! Congrats to @patwsheehan for incredible work and to our collaborators @johnthefryer, @CarpeRibosomam, @darshan1s, Ron Anafi, and the team. @johnthefryer and I started this in 2019! nature.com/articles/s4159…
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Pat Sheehan retweetledi
Amazing work from @TravisFaust2 in my lab @UMassChan @UMassNeuro @NeurobioUMass. Very proud of this work. Also thanks to fantastic collaborators Anne Schaefer, Pinar Ayata, Cagla Eroglu, and colleagues.
Travis Faust@TravisFaust2
Thrilled to share our new paper in @CellCellPress: “Microglia–astrocyte crosstalk regulates synapse remodeling via Wnt signaling” This work demonstrates the necessity of glia–glia communication and cooperation. cell.com/cell/fulltext/… Faust et al., Cell 2025 #Neuroscience #Glia
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Pat Sheehan retweetledi
Excited to share our new work demonstrating a role for astrocytic inflammasome signaling in modulating hippocampal plasticity.
All credit to @kzengeler, who was the brains🧠 and muscle💪 behind this project and is a wonderful collaborator.
Kristine Zengeler@kzengeler
Happy to share our work on hippocampal inflammasome signaling. Thank you to members of the lab for critical experimental support, @BIG_Center_UVA colleagues for input, and @LukensJohnR for baller mentorship - it's been an honor working with you all! cell.com/immunity/fullt…
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Pat Sheehan retweetledi
The university will not surrender its independence or relinquish its constitutional rights. Neither Harvard nor any other private university can allow itself to be taken over by the federal government. hrvd.me/ResearchFundin…
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Hot preprint alert!!! Please check out our study led by the amazing @piasglia on how mitochondrial fission regulates astrocyte morphogenesis! Unexpected findings linking astrocyte mitochondria to tiling and gap junction coupling!!! biorxiv.org/content/10.110…
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Pat Sheehan retweetledi
Super excited to share our new article co-led by really talented undergraduate student Nicholas Sweeney and BSGP PhD student Tae Yeon Kim! Thanks all the fantastic collaborators, trainees, reviewers, and the Editor for this very nice publication!
link.springer.com/10.1007/s00401…
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Pat Sheehan retweetledi
Excited about our new paper just hot off the press from Journal of Neuroinflammation: rdcu.be/dUC9Q
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For anyone interested in microglia (brain-resident immune cells), circadian rhythms, and Alzheimer’s disease, I encourage you to read this paper (or the thread).
Amazing work! Well done 👏
Pat Sheehan@patwsheehan
My final paper from my PhD with @ErikMusiek is now on biorxiv! We asked if microglia and astrocytes have the ability to change which genes are expressed in rhythmic manner during Alzheimer's pathology and during normal aging. biorxiv.org/content/10.110…
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@Da_Mesquita_S @ImmunityCP @dasNeves_SP I'm excited to check it out! Congrats @Da_Mesquita_S and @dasNeves_SP !!
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Pat Sheehan retweetledi
🧵 Excited to share my first preprint from my PhD @kipnislab and @TheColonnaLab: "Brain-Engrafted Monocyte-derived Macrophages from Blood and Skull-Bone Marrow Exhibit Distinct Identities from Microglia." 🧠🦴
biorxiv.org/content/10.110…
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