Prit Benny Malgulwar

VIDEO | Delhi: Prof. Sheffali Gulati, Faculty In-charge, Pediatric Neurology Division, AIIMS says, "In autism spectrum disorder, a lot of research has been done globally. It has been observed that children who had higher screen time at the age of one showed a higher prevalence of autism by the age of three, especially in boys, though it is also seen in girls." (Full video available on ptivideos.com)

Our Human Multiomic Development Atlas paper is out in Nature today! A heart-felt "thank you" to all co-authors for their tireless work on this complex yet exciting project! Congrats all! nature.com/articles/s4158…

Aging clocks may be shaped by neurosyndemics, multiple interacting physical and social real-world environments jointly influencing brain health. Out in Nature Medicine (nature.com/articles/s4159…), we assessed 18,701 participants from 34 countries, showing that the combined aggregate-level exposome (73 physical, social, and political factors measured at country-level) predicts multimodal brain aging far better than isolated exposures (up to 15-fold more variance). Moving beyond single risks, we provide evidence that synergistic, nonlinear exposome burden accelerates brain clocks across health and disease, with physical exposures linking more strongly to structural brain aging and social exposures to functional brain aging. Exposome burden increased the risk of accelerated brain aging by 3.3–9.1-fold, in some cases exceeding the effects associated with dementia, and these findings held in out-of-sample, longitudinal, individual-level variation, and sensitivity analyses. Thus, the pace at which the brain ages may be shaped by syndemic environmental and societal conditions, calling for much more intersectoral policies. Congrats @AgustinaLegaz Sebastian Moguilner @HernHdezL & all coauthors. 1/5👇 @GBHI_Fellows

Multiple recent papers (two just this week) highlighting the role of inflammation in sculpting “epigenetic memory” and promoting tumorigenesis across various solid organs. science.org/doi/10.1126/sc… nature.com/articles/s4158… science.org/doi/10.1126/sc… cell.com/developmental-…

New Lab Alert! 🧬 labadelab.com Thrilled to start the Labade Lab at @AshokaUniv! @TSB_Ashoka @KCDH_A Join us to explore expansion microscopy, nanoscale spatial genomics, and the epigenetics of aging. PhD Program at Ashoka for 2026-27 intake. Apply by 20 April 2026: ashoka.edu.in/programme/phd-… We’re investigating how "inflammaging" alters the epigenome and how to decipher and ultimately reverse those changes. We build new technologies to visualize genome & epigenome changes at the nanoscale and explore ways to make the genome more resilient to aging. #PhD #SpatialGenomics #ExpansionMicroscopy #Inflammaging

Our paper is out in @ScienceMagazine Here we describe how stem cell retain epigenetic inflammatory memory long-term. Full text in the link below! Congratulations @chris_cowley14 @SairajSajjath @LFSoto12 and everyone else involved! science.org/doi/10.1126/sc…

It’s well known that inflammation increases cancer risk, but how? The answer: the epigenome "remembers" inflammation and primes stem cells for cancer. Here is our paper: nature.com/articles/s4158… And a special shoutout to the lead author @snaga13 A 🧵

We're seeking to fill two roles: a PDRA and an RA. These positions will investigate resistance mechanisms in brain tumour models using in vivo models, spatial omics, CRISPR. Please apply if previous experience aligns! Here is the RA job advertisement: shorturl.at/NVl1V

We developed a single-molecule, multi-modal spatial genomics approach to visualize the structure and function of >100,000 individual extrachromosomal DNA (ecDNA) molecules in their native contexts. Preprint link at the end of the thread. (1/11)

Thrilled to share my lab’s new paper out in @genomeresearch where we use chromosome engineering to deconstruct 8p syndrome - a rare developmental condition caused by inversions, duplications, and deletions on chromosome 8p.

(1/5) How does glioblastoma maintain its immense heterogeneity? 🧠 Two new companion papers from the Bhaduri Lab @UCLA now on @bioRxiv offer a lineage-resolved view of GBM hierarchies. Let’s dive in! 🧵👇 biorxiv.org/content/10.648… biorxiv.org/content/10.110…

Hi-C for genome-wide detection of enhancer-hijacking rearrangements in routine lymphoid cancer biopsies dlvr.it/TR4Dhs

Happy to share our Current Opinion review on the key challenges in accurately predicting 3D distances between chromatin segments and computing their dynamics. Thanks to Daniel Jost @djost_physbiol & Luca Giorgetti for the invitation to write this review @DuttaShuvadip @BsbeIitb

Exited to share Current Opinion review on how chromatin hubs involving multiple enhancers and promoters are formed, and their potential roles in gene regulation: sciencedirect.com/science/articl…. @zubi___ @Sakshi_Shigvan @Amanjsingh1996 @NCBS_Bangalore

Super excited to share our recent work on ependymomas spearheaded by the indomitable @shiva251993. nature.com/articles/s4158…

Check this new work on BRD4's role in preventing the premature activation of developmental transcription factors via #Polycomb, providing new mechanistic insights into the pathogenesis of neurodevelopmental disorder #CdLS #NDDs, #chromatinopathies biorxiv.org/content/10.648…

Mizuho Postdoctoral Fellowship at @CRI_ACTREC @ACTREC_TMC My lab will be hosting a postdoc in the following research area! Interested PhD students please apply through the following link: actrec.gov.in/jobs @biopatrika @VoicesofIndAcad

Does the noncoding genome actually carry more genetic information than coding seqs? Motivated by this question we mutated every bp in the 10kb MYC locus. Results are even more exciting: Decoding the MYC locus reveals a druggable ultraconserved RNA element biorxiv.org/content/10.648…

Epitranscriptomic control of cancer hallmarks: Functions, mechanisms, and therapeutics of RNA modifications cell.com/cancer-cell/ab…

2026 has just begun and we are looking forward to welcoming you to EMBL for another year of groundbreaking science. Our programme now features even more events, check it out ➡️ s.embl.org/2026-poster