Boris Hadaschik

597 posts

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Boris Hadaschik

Boris Hadaschik

@ProfHadaschik

Urologic oncologist & surgeon; Chairman, Department of Urology, Pediatric Urology and Urooncology, University Hospital Essen

Essen, Deutschland Katılım Ekim 2018
164 Takip Edilen616 Takipçiler
Boris Hadaschik
Boris Hadaschik@ProfHadaschik·
I am leaving X with a sad eye moving on to more reasonable platforms.
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Dougie Kass Private
Dougie Kass Private@TylerSbrt·
Please share on/off X! Great learning opportunity for all physicians who diagnose/treat #ProstateCancer “Answer 🔑” = 4 specialists (2 #radonc, 2 #radiology) sat down together to create a reference standard All levels welcome! Share w/trainees @ASTRO_org @ARRO_org @so_uro
Dougie Kass Private@TylerSbrt

🚨🚨Prostate and UREthra on MRI (PURE-MRI): Try to contour (outline) the prostate and urethra on MRI for 1 patient After everyone is done, we will enable the “answer key” And you help us learn how to help doctors and AI do better Sign up here: redcap.link/PURE-MRI 🙏🏼

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Boris Hadaschik
Boris Hadaschik@ProfHadaschik·
Happy to share: Prostate-specific Membrane Antigen (PSMA) Spatial Biomarker: Standardized Positron Emission Tomography Disease Maps Provide Accurate Prediction of Overall Survival in Prostate Cancer - ScienceDirect sciencedirect.com/science/articl…
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silke gillessen
silke gillessen@Silke_Gillessen·
We are very proud that the paper is online! Sincere thanks to our scientific committee and all panellists. Manuscript is open access, please use and distribute it! Hope to see you at the first edition of @APCCC_Lugano Diagnostics @ProfKHerrmann @stefanofanti4
Advanced Prostate Cancer Consensus Conference@APCCC_Lugano

A great Pleasure to Present our paper on Management of patients with Advanced #ProstateCancer : A Report from #APCCC24 LINK TO ARTICLE👇👇👇👇👇👇👇👇 sciencedirect.com/science/articl… The 2024 Advanced Prostate Cancer Consensus Conference (APCCC) highlights significant advances in prostate cancer management while underscoring areas where high-quality evidence is still lacking. The conference gathered expert opinions on controversial clinical issues, particularly in advanced prostate cancer, offering guidance in cases where guidelines are unclear or conflicting. The report emphasizes personalized treatment approaches, considering patient-specific factors and evolving clinical data, and stresses the importance of ongoing clinical trials to fill knowledge gaps. It provides a practical framework for physicians and patients to engage in shared decision-making, especially in complex cases of high-risk localized and locally advanced prostate cancer. Our Thanks to all authors: @Silke_Gillessen @fabioturco92 @Prof_IanD @drjefstathiou Karim Fizazi @Prof_Nick_James Neal Shore Eric Small Matthew Smith @ChrisSweens1 @BertrandTOMBAL @ZilliThomas @neerajaiims Emmanuel S. Antonarakis Ana Aparicio Andrew J. Armstrong Diogo Assed Bastos Gerhardt Attard Karol Axcrona Mouna Ayadi Himisha Beltran @bjartell @PBlanchardMD @BourlonMaite @Albert0Briganti Muhammad Bulbul Consuelo Buttigliero Orazio Caffo @cdanicas @Ecastromarcos Heather H. Cheng Kim N. Chi Caroline S. Clarke Noel Clarke Johann S. de Bono @mdesantis234 @nachoduranm @EfstathiouEleni Onyeanunam N. Ekeke Tamer I.H. El Nahas @drlouiseemmett @stefanofanti4 Omolara A. Fatiregun Felix Y. Feng Peter C.C. Fong @fontev1 @Nicola_Fossati Daniel J. George @marty_gleave Gwenaelle Gravis Susan Halabi Daniel Heinrich @ProfKHerrmann @DrMHofman Thomas A. Hope Lisa G. Horvath Maha H.A. Hussain @BarbaraJereczek Robert J. Jones Anthony M. Joshua @ravikanesvaran Daniel Keizman @FacsRaja Gero Kramer @LoebStacy Brandon A. Mahal Fernando C. Maluf 75 76, @quimmateo David Matheson 78, Mika P. Matikainen 79, Ray McDermott 80, @DrRanaMcKay Niven Mehra 82, @amerseburger @CaPsurvivorship , Michael J. Morris 85, Hind Mrabti 86, Deborah Mukherji @declangmurphy Vedang Murthy Shingai B.A. Mutambirwa @DrPaulNguyen William K. Oh @piet_ost Joe M. O’Sullivan Anwar R. Padhani Chris Parker Darren M.C. Poon Colin C. Pritchard Danny M Rabah Dana Rathkopf Robert E. Reiter Raphaele Renard-Penna Charles J. Ryan Fred Saad Juan Pablo Sade Shahneen Sandhu Oliver A. Sartor Edward Schaeffer Howard I. Scher Nima Sharifi Iwona A. Skoneczna Howard R. Soule @DrSpratticus Sandy Srinivas @cnsternberg Hiroyoshi Suzuki Mary-Ellen Taplin Camilla Thellenberg-Karlsson Derya Tilki Levent N. Türkeri Hiroji Uemura @DrYukselUrun Claire L. Vale Neha Vapiwala Jochen Walz Kosj Yamoah Dingwei Ye Evan Y. Yu Almudena Zapatero @AOmlin

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Alastair Lamb
Alastair Lamb@LambAlastair·
Delighted to share our latest on #18F_PSMA_PET just published in cool new @JUOpenPlus! •n=1335 scans from 1220 men •1°: PSMA 96% vs MRI 89% sens. for pros lesions at RP •2°: PSA 0.2-0.49 post RP/RT ➡️ avidity in 57.8% BUT high false +ves (esp ribs) journals.lww.com/juop/fulltext/…
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Vincent J Gnanapragasam
Vincent J Gnanapragasam@VincentGnanapr3·
Our latest paper on risk stratified prostate cancer testing - TARGET study, a simultaneous evaluation of PRS, PSAd, F/T PSA, phi in a PSA triggered MRI diagnostic pathway + testing different defn of ‘clinical significance’ link.springer.com/10.1186/s12916…
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NEJM
NEJM@NEJM·
In patients with muscle-invasive bladder cancer, extended lymphadenectomy did not improve disease-free or overall survival as compared with the standard procedure and was associated with higher morbidity and mortality. Full SWOG S1011 trial results: nej.md/4dBI8UN
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Alison Tree 💙
Alison Tree 💙@alison_tree·
Outstanding presentation by @drjefstathiou #ASTRO24 showing no improvement in any outcome with proton therapy for localised prostate cancer compared to photon therapy. Congratulations to all authors! 👏
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Viktor Grünwald
Viktor Grünwald@ViktorGruenwald·
the study did not show a meaningful difference. DFS was improved in pts with higher risk of recurrence, such as sRCC, PDL1+ or T4. Getting patient populations right is of clinical interest and leads to stronger recommendations in these groups of patients in my daily practice
OncoAlert@OncoAlert

Adjuvant Nivolumab for Localized Renal Cell Carcinoma at High Risk of Recurrence After Nephrectomy: Part B of the Randomized, Placebo-Controlled, Phase III CheckMate 914 Trial out on @JCO_ASCO The CheckMate 914 ♟️trial is a phase III study that evaluated the efficacy of adjuvant nivolumab🧪 monotherapy (part B) versus placebo in patients with localized renal cell carcinoma (RCC) at high risk of recurrence after nephrectomy. #KidneyCancer In this randomized trial of 825 patients, the primary endpoint of disease-free survival (DFS) per blinded independent central review (BICR) was not met, with a hazard ratio (HR) of 0.87 (95% CI, 0.62 to 1.21; P = .40). Although the 18-month DFS rates were slightly higher in the nivolumab group (78.4% vs. 75.4% for placebo), the difference was not statistically significant. Adverse events, particularly grade 3-4 events, were more common with nivolumab plus ipilimumab, leading to higher treatment discontinuation rates. Overall, the study did not demonstrate a DFS benefit for nivolumab in this patient population. ascopubs.org/doi/full/10.12… @motzermd @YoshihikoTomita @HernanJCutuli @grimm_mo @JeffreyCGoh1 @BrianShuch @ViktorGruenwald #OncoAlertAF @nataliagandur @acampsmalea @BiagioRicciutMD @yekeduz_emre @HHorinouchi @FadiHaddad_MD @Dr_Ivanoncologo @Abdallah81MD @FernandoOnco @ElisaAgostinett @to_be_elizabeth @lungoncdoc @bavilima @realbowtiedoc @Erman_Akkus @DrFMartinelli @Lucarecco @heinrich_kat @niklas_kluemper

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NEJM
NEJM@NEJM·
After 4 years of the GÖTEBORG-2 trial, MRI-targeted biopsy led to less detection of clinically insignificant prostate cancer than systematic biopsy without compromising the detection of cancer that may affect survival. Read the full trial results: nej.md/4ewOjKT
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NEJM
NEJM@NEJM·
Neoadjuvant chemotherapy plus durvalumab, followed by adjuvant durvalumab after cystectomy, led to event-free survival superior to that with neoadjuvant chemotherapy followed by cystectomy alone. Full NIAGARA trial results: nej.md/4gmAqk3 #ESMO24
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NEJM
NEJM@NEJM·
AMBASSADOR trial: After cystectomy, patients with muscle-invasive bladder cancer were randomly assigned to pembrolizumab or observation for 1 year. The pembrolizumab group had a median disease-free survival twice as long as the observation group. nej.md/4gh1b9D #ESMO24
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Michael Hofman
Michael Hofman@DrMHofman·
☢ UpFrontPSMA "Live #ESMO24": Lutetium-177 PSMA-617 followed by docetaxel improved anti-tumour activity in men with new diagnosis of metastatic hormone-sensitive prostate cancer compared with docetaxel alone, without increased side effects 🔥Hot off the press @TheLancetOncol: thelancet.com/journals/lanon… 💊Lu-PSMA followed by docetaxel vs. docetaxel alone (130 men randomised) 🎯Undetectable PSA at 1 year: 41% vs 16% (OR 3·88; p=0·0020) 💥No additional side effects with Lu-PSMA ✅Secondary endpoints favour Lu-PSMA as well 🎥Watch it on GU Cast: youtu.be/S_JvSVlOdZ8 Investigator-led study @AzadOncology @PeterMacCC Big shout out to @MovemberAUS and all other funders & supporters @CDMRP @UniMelb #VCA #MRFF @ANSTO @Novartis @pros_tic Thanks to @ANZUPtrials #ARTnet 👏UprontPSMA Study Team all around Australia
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Viktor Grünwald
Viktor Grünwald@ViktorGruenwald·
#sunniforecast investigated whether IPI-NIVO is superior to SOC (mainly TKI single agent) in ncc-RCC subtypes. All pts. had central pathology. IPI-NIVO had superior OS and supports its role in these rare subtypes. The benefit in chRCC was unexpected. PD-L1+ had highest benefits
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