Boris Hadaschik

606 posts

Boris Hadaschik banner
Boris Hadaschik

Boris Hadaschik

@ProfHadaschik

Urologic oncologist & surgeon; Chairman, Department of Urology, Pediatric Urology and Urooncology, University Hospital Essen

Essen, Deutschland Katılım Ekim 2018
163 Takip Edilen626 Takipçiler
Boris Hadaschik
Boris Hadaschik@ProfHadaschik·
@Prof_Nick_James agree that comparison to ENZARAD and ATLAS very useful - however challenging because of slightly different entry criteria and endpoints. PROTEUS had specific demands for high numbers of involved cores. cT staging not easy to compare because of differences in use of DRE vs imaging
English
0
0
4
1.5K
Nick James
Nick James@Prof_Nick_James·
Need to benchmark against ENZARAD - similar pts, similar MFS and both negative for adding ARPI on conventional imaging. Hard to see why this is being called a positive trial. Essentially trading ADT now for ADT later, not sure if this is a benefit or not.
Neeraj Agarwal, MD, FASCO@neerajaiims

Breaking news #ASCO26 👉Ph3 PROTEUS trial👉Periop ADT + apalutamide in high-risk localized/locally advanced #prostatecancer undergoing radical prostatectomy👉↑ pathologic response (8.9% vs 1.0%) & 5-yr metastasis-free survival (78.2% vs 73.5%; HR 0.80) @urotoday @OncoAlert

English
3
6
36
5K
Boris Hadaschik
Boris Hadaschik@ProfHadaschik·
@DrSpratticus @ChapinMD In the NED at 4yrs data there is a lot of censoring we need to understand better. The BCR rates look better. MFS on conventional imaging is not negative but premature, given the low number of events.
English
1
0
0
184
Daniel E Spratt
Daniel E Spratt@DrSpratticus·
7/7 #ASCO26 NEJM paper PROTEUS: - very high recurrence rates (~80% at 4 years were not disease free despite triplet therapy) - very low rates of post-op RT (25-35%) - 1 in 5 men did not recover T to low normal levels -negative MFS on conventional imaging - numerically worse OS in ARPI arm Look forward to correlative work. This will always be a challenging space as some of these men may be cured by RP, and if not can receive early SRT with biomarker guided systemic therapy intensification. Massive congrats to study team and sponsor.
English
3
14
51
3.3K
Daniel E Spratt
Daniel E Spratt@DrSpratticus·
#ASCO26 Talk about real-time updates. NEJM paper now online and my predictions and inferences appear true. Majority of MFS events were by PET not conventional imaging. "Most distant metastases were identified by PSMA PET (53.0% of those in the apalutamide group and 60.7% in the placebo group)" VERY IMPORTANTLY: "No significant between-group difference was observed in metastasis-free survival assessed with conventional imaging alone (hazard ratio, 0.84; 95% CI, 0.67 to 1.07)" Not only does MFS cross 1, but the HR also crosses the surrogate threshold effect (0.81). @urotoday @PCF_select @US_FDA
Daniel E Spratt@DrSpratticus

#ASCO26 The PROTEUS trial results are now online...buckle up as we wait to see the full presentation. This is going to be a trial that is likely highly controversial until the full results are published. Some may call this a homerun, others may call this the largest negative trial @ASCO 2026. Up to you to interpret! @urotoday @EricTopol @DrChoueiri @neerajaiims @ASCO @US_FDA @NCCN @myESMO @ASTRO_org @PCF_Science @declangmurphy @mcuban

English
3
32
76
13K
Boris Hadaschik
Boris Hadaschik@ProfHadaschik·
To cure a larger fraction of patients with high risk disease we will need a truly integrated approach. I am surpised that there was not more salvage RT in PROTEUS.
English
0
0
1
73
Boris Hadaschik
Boris Hadaschik@ProfHadaschik·
Perioperative Apalutamide in High-Risk Localized Prostate Cancer | New England Journal of Medicine nejm.org/doi/full/10.10… Honored to be involved - lots to discuss and lots to come
English
3
0
5
333
Boris Hadaschik
Boris Hadaschik@ProfHadaschik·
It adds data to the discussion. The RP only substudy comes next year. SPCG15 will be very important. Primary PET staging not available in PROTEUS. Comparison to ENZARAD and ATLAS will be interesting… I am very happy that PROTEUS is positive.
English
0
0
2
125
Boris Hadaschik
Boris Hadaschik@ProfHadaschik·
@DrSpratticus @TylerSbrt The assumptions were complicated because of the dual primary endpoint (at least for a Urologist…) Will be shown on Sunday. Furthermore PSMA onboarded during the trial. Many important clinical endpoints and many discussions to come.
English
0
0
1
39
Daniel E Spratt
Daniel E Spratt@DrSpratticus·
@TylerSbrt You would think study team members might know this. The other trials, including company sponsored trials in this space all reported their planned HR before reading out.
English
1
0
3
319
Tyler Seibert MD PhD
Tyler Seibert MD PhD@TylerSbrt·
@DrSpratticus Probably have to go straight to the company with this question? I hope this is required by the reviewers/editors for full publication.
English
2
0
1
457
Boris Hadaschik retweetledi
Advanced Prostate Cancer Consensus Conference
New prostate cancer risk groups by PSMA-PET (PPP3): an international, retrospective, registry-based cohort study thelancet.com/journals/lanon… In an international registry study of 11,154 patients, investigators developed PPP3 nomograms integrating clinical features and PSMA-PET PROMISE metrics to predict 3-, 5-, and 7-year overall survival in #ProstateCancer Developed and validated across 35 global sites, ✅ Models demonstrated strong discrimination (C-index ~0.83–0.84). ✅PPP3 performed as well as or better than existing clinical risk scores, supporting PSMA-PET–based risk stratification for guidelines, clinical decision-making, and trial design. @CalaisJeremie @DrMHofman @thomashopemd @drlouiseemmett @DrAGafita @ProfKHerrmann @ProfHadaschik @Dr_K_Rahbar @bjartell @OncoAlert 🚨 @silkegillessen @AOmlin @weoncologists #EAU26
Advanced Prostate Cancer Consensus Conference tweet media
English
0
25
54
3.2K
Boris Hadaschik
Boris Hadaschik@ProfHadaschik·
back on X for scientific reasons because the alternative platforms unfortunately did not fulfill my expectations
English
3
2
10
806
Boris Hadaschik
Boris Hadaschik@ProfHadaschik·
I am leaving X with a sad eye moving on to more reasonable platforms.
English
0
0
1
262
Boris Hadaschik
Boris Hadaschik@ProfHadaschik·
Happy to share: Prostate-specific Membrane Antigen (PSMA) Spatial Biomarker: Standardized Positron Emission Tomography Disease Maps Provide Accurate Prediction of Overall Survival in Prostate Cancer - ScienceDirect sciencedirect.com/science/articl…
English
0
2
12
1.3K
Boris Hadaschik retweetledi
silke gillessen
silke gillessen@Silke_Gillessen·
We are very proud that the paper is online! Sincere thanks to our scientific committee and all panellists. Manuscript is open access, please use and distribute it! Hope to see you at the first edition of @APCCC_Lugano Diagnostics @ProfKHerrmann @stefanofanti4
Advanced Prostate Cancer Consensus Conference@APCCC_Lugano

A great Pleasure to Present our paper on Management of patients with Advanced #ProstateCancer : A Report from #APCCC24 LINK TO ARTICLE👇👇👇👇👇👇👇👇 sciencedirect.com/science/articl… The 2024 Advanced Prostate Cancer Consensus Conference (APCCC) highlights significant advances in prostate cancer management while underscoring areas where high-quality evidence is still lacking. The conference gathered expert opinions on controversial clinical issues, particularly in advanced prostate cancer, offering guidance in cases where guidelines are unclear or conflicting. The report emphasizes personalized treatment approaches, considering patient-specific factors and evolving clinical data, and stresses the importance of ongoing clinical trials to fill knowledge gaps. It provides a practical framework for physicians and patients to engage in shared decision-making, especially in complex cases of high-risk localized and locally advanced prostate cancer. Our Thanks to all authors: @Silke_Gillessen @fabioturco92 @Prof_IanD @drjefstathiou Karim Fizazi @Prof_Nick_James Neal Shore Eric Small Matthew Smith @ChrisSweens1 @BertrandTOMBAL @ZilliThomas @neerajaiims Emmanuel S. Antonarakis Ana Aparicio Andrew J. Armstrong Diogo Assed Bastos Gerhardt Attard Karol Axcrona Mouna Ayadi Himisha Beltran @bjartell @PBlanchardMD @BourlonMaite @Albert0Briganti Muhammad Bulbul Consuelo Buttigliero Orazio Caffo @cdanicas @Ecastromarcos Heather H. Cheng Kim N. Chi Caroline S. Clarke Noel Clarke Johann S. de Bono @mdesantis234 @nachoduranm @EfstathiouEleni Onyeanunam N. Ekeke Tamer I.H. El Nahas @drlouiseemmett @stefanofanti4 Omolara A. Fatiregun Felix Y. Feng Peter C.C. Fong @fontev1 @Nicola_Fossati Daniel J. George @marty_gleave Gwenaelle Gravis Susan Halabi Daniel Heinrich @ProfKHerrmann @DrMHofman Thomas A. Hope Lisa G. Horvath Maha H.A. Hussain @BarbaraJereczek Robert J. Jones Anthony M. Joshua @ravikanesvaran Daniel Keizman @FacsRaja Gero Kramer @LoebStacy Brandon A. Mahal Fernando C. Maluf 75 76, @quimmateo David Matheson 78, Mika P. Matikainen 79, Ray McDermott 80, @DrRanaMcKay Niven Mehra 82, @amerseburger @CaPsurvivorship , Michael J. Morris 85, Hind Mrabti 86, Deborah Mukherji @declangmurphy Vedang Murthy Shingai B.A. Mutambirwa @DrPaulNguyen William K. Oh @piet_ost Joe M. O’Sullivan Anwar R. Padhani Chris Parker Darren M.C. Poon Colin C. Pritchard Danny M Rabah Dana Rathkopf Robert E. Reiter Raphaele Renard-Penna Charles J. Ryan Fred Saad Juan Pablo Sade Shahneen Sandhu Oliver A. Sartor Edward Schaeffer Howard I. Scher Nima Sharifi Iwona A. Skoneczna Howard R. Soule @DrSpratticus Sandy Srinivas @cnsternberg Hiroyoshi Suzuki Mary-Ellen Taplin Camilla Thellenberg-Karlsson Derya Tilki Levent N. Türkeri Hiroji Uemura @DrYukselUrun Claire L. Vale Neha Vapiwala Jochen Walz Kosj Yamoah Dingwei Ye Evan Y. Yu Almudena Zapatero @AOmlin

English
1
29
85
10K
Boris Hadaschik retweetledi
Alastair Lamb
Alastair Lamb@LambAlastair·
Delighted to share our latest on #18F_PSMA_PET just published in cool new @JUOpenPlus! •n=1335 scans from 1220 men •1°: PSMA 96% vs MRI 89% sens. for pros lesions at RP •2°: PSA 0.2-0.49 post RP/RT ➡️ avidity in 57.8% BUT high false +ves (esp ribs) journals.lww.com/juop/fulltext/…
Alastair Lamb tweet mediaAlastair Lamb tweet mediaAlastair Lamb tweet mediaAlastair Lamb tweet media
English
0
6
21
2.7K
Boris Hadaschik retweetledi
Vincent J Gnanapragasam
Vincent J Gnanapragasam@VincentGnanapr3·
Our latest paper on risk stratified prostate cancer testing - TARGET study, a simultaneous evaluation of PRS, PSAd, F/T PSA, phi in a PSA triggered MRI diagnostic pathway + testing different defn of ‘clinical significance’ link.springer.com/10.1186/s12916…
English
1
2
4
837
Boris Hadaschik retweetledi
NEJM
NEJM@NEJM·
In patients with muscle-invasive bladder cancer, extended lymphadenectomy did not improve disease-free or overall survival as compared with the standard procedure and was associated with higher morbidity and mortality. Full SWOG S1011 trial results: nej.md/4dBI8UN
NEJM tweet media
English
7
108
263
75.8K