Nathan Reticker-Flynn

Tumors spread to lymph nodes before they metastasize to distant tissues, but for over a century scientists have debated whether this matters. It does. Check out our paper online now @CellCellPress @CellPressNews cell.com/cell/fulltext/… 1/15

If you're interested in hearing about lymph node metastasis, tumor evolution, T cells, and immunotherapy, check out this @theNCI forum tomorrow, featuring Mary Jo Turk, @naxerova, and Alexander Huang. events.cancer.gov/dcb/tdln #TDLNForums

When tumors colonize lymph nodes, they induce a LOT of changes to the immune and stromal populations in the involved LN and beyond, throughout the induction of Metastatic Tolerance. Check out this great study and rich resource describing these changes. Congrats @Max_Haist !

Happy to share our latest @sigtrans_sttt commentary on two beautiful @Nature papers on #ferroptosis and #cancer. Kudos to these 2 teams for their beautiful work! @j_ubellacker @luciaborriell @FoxChaseCancer nature.com/articles/s4139…

Thanks to @NatRevImmunol and the @preprintclub for highlighting our recent study on divergent evolution and type I interferon

@YMphoenix @Cancer_Cell Congrats Phoenix. Great story!

Thrilled to share the new work published on @Cancer_Cell from our lab reporting the critical roles of tumor initiating cells in shaping the cell states of tumor associated neutrophils. sciencedirect.com/science/articl…

Evolution Under Therapy: Resistance Mechanisms— Andrew J. Aguirre, Nathan E. Reticker-Flynn, Susan M. Rosenberg, and Kathleen Burkhardt addressed this topic in a plenary session at the AACR Special Conference on Cancer Evolution. #AACRevol25 @RetickerFlynn @SusanRosenberg8

What if nature already has the optimal cytokine solution for T cell therapy, but we just haven’t found it yet? Check out our paper out today in Immunity on IL-9 as a naturally orthogonal cytokine ideally tuned for T cell therapy authors.elsevier.com/sd/article/S10… 1/9

Nature research paper: Lymph node environment drives FSP1 targetability in metastasizing melanoma go.nature.com/4oiPnY2

Thrilled to see Mario's work on FSP1 out, providing evidence in melanoma alongside lung cancer that there may be alternatives for targeting ferroptosis! Glad we could help with this work including providing our LN metastasis model for in vivo validation

Therapeutic benefit of intratumoral inhibition of FSP1 & ferroptosis in pre-clinical lung cancer and versus melanoma growth in lymph nodes @Nature @ThalesPapaG @nyugrossman @HarvardEpi nature.com/articles/s4158… nature.com/articles/s4158…

Two new Nature papers show that inhibiting FSP1 is sufficient to restrict tumor growth in vivo, a major step forward for ferroptosis-targeted cancer therapy. Huge congrats to all authors! nature.com/articles/s4158… nature.com/articles/s4158… #Ferroptosis #FSP1 #CancerResearch

Evolution Under Therapy: Resistance Mechanisms— Andrew J. Aguirre, Nathan E. @RetickerFlynn, @SusanRosenberg8, and Kathleen Burkhardt will address this topic in a plenary at the AACR Conference on Cancer Evolution (Dec 4-6; Albuquerque). brnw.ch/21wWYfD #AACRevol25

@biorxivpreprint See the tweetorial from @CortBreuer ☝️and the preprint 👇 biorxiv.org/content/10.110…

Tumors often metastasize to lymph nodes before distant sites, yet evidence suggests that distant mets can originate from unique clones. Is this divergent seeding random? No. Check out our newest @biorxivpreprint to learn how the mechanisms diverge and how to harness them for IO.

Pleasure to share a tremendous body of work from @YangZhao102, who led the next chapter of the powerful orthogonal IL-2 technology from the Garcia Lab (where the innovative spirit is unmatched). Grateful for this ongoing collaboration, stay tuned for more. rdcu.be/eACgC

Excited to see our protocol out today on spontaneous and experimental models of LN metastasis in @NatureProtocols! Though a straightforward system conceptually, getting these models working reliably took more time than originally expected so I hope this is a resource to everyone.

And if you're interested in investigating what is happening in the lymph fluid itself, check out this great protocol by the Ubellacker Lab nature.com/articles/s4159…

If you're interested in trying out these protocols in your own lab, we are making the cell lines available through @CancerToolsOrg cancertools.org/cell-lines/nbf…

Interested in studying lymph node metastasis? Check out our protocol by @CortBreuer out today in @NatureProtocols