Danny Saban

So the question is not only: where do resident macrophages come from? It is also: when does self-maintenance become durable, and when does it fail to do so? That is the problem Establishment Kinetics is meant to solve. Full paper in Advances in Immunology sciencedirect.com/science/chapte…

We’re proud to share that W. Daniel Stamer, PhD, FARVO has been elected the next Executive Vice President of @ARVOinfo Join us in congratulating Dr. Stamer on this outstanding achievement and his continued impact on advancing vision research. dukeeyecenter.duke.edu/news/daniel-st…

What defines human pDC diversity? Our newest work led by @UlezkoAlina in @ImmunityCP uncovers a complex landscape shaped by age and tissue niche, including a cycling pDC subset that declines with age but persists in the BM & expands in malignant BPDCN. shorturl.at/99Zui

Spatial proteomic mapping of the human and mouse retina using IBEX @JCI_insight @ucl insight.jci.org/articles/view/…

The proposed FY2027 budget includes a $5.8B (−12.3%) cut to the NIH. United for Medical Research calculated this could cost ~50,000 jobs and $11.6B in economic activity, with 26 states losing >$100M each. A tragedy for science, patients, and the economy. #NIH

We’re proud to share VISION 2026, highlighting the momentum and progress across the Duke Eye Center. Read: #page/1" target="_blank" rel="nofollow noopener">heyzine.com/flip-book/0fa2…

Artist Noga Erez became the first Israeli artist to perform at Coachella 🇮🇱 At the end of her set, she said she was deeply grateful to be there, adding that it took strength she didn’t know she had to get here. She also said she loves making music and that she does it to bring people together. What a show!

Neutralizing antibodies are not the whole story. Very cool!

@jonykipnis חג שמח יוני!

Happy Passover to all who celebrate! Special wishes to all “some-of-my-best-friends-are-Jews” Israel haters. I’m so happy you speak up and show your ugly selves! ‘Love’ all of you back!

@SEStorck Agreed

@SabanLab Let’s drop the “eye“

We argue for sunsetting the M1/M2 dichotomy in eye macrophage research, supported by single cell RNA-seq data demonstrating a complexity that does not conform to this binary framework. 50 day free link sciencedirect.com/science/chapte…

Was a blast guest editing this special issue for @J_Immunol . Check out these amazing reviews on brain border sites. academic.oup.com/jimmunol/artic…

50 day free link nam11.safelinks.protection.outlook.com/?url=https%3A%…

So the question is not only: where do resident macrophages come from? It is also: when does self-maintenance become durable, and when does it fail to do so? That is the problem Establishment Kinetics is meant to solve. Full paper in Advances in Immunology sciencedirect.com/science/chapte…

Resident tissue #macrophages (RTM) are now recognized as integral regulators of tissue physiology, not transient immune sentinels. But one fundamental question remains unresolved: why do some populations achieve lifelong self-maintenance, while others are progressively replaced under steady-state conditions? 🧵

@r_sankowski @JustinPerryPhD nam11.safelinks.protection.outlook.com/?url=https%3A%… - does this work?

@SabanLab @JustinPerryPhD Great stuff! Do you have an unpaywalled link by any chance?

@JustinPerryPhD We focused on normal physiological conditions as a starting point , but totally agree with you

@SabanLab Interesting. Will take a read through. I think future consideration should also be played to infection exposure. Sterile mice, for instance, have long-lived self-renewing alveolar macrophages (eg meeting your EK) but humans likely have mono-Mac replaced AM compartment.

Macrophage lineage and spatial compartmentalization govern tumor immunity @NatImmunol @claudjak @soubhik1992 @RawatKSM @XinLi0419 @AishwaryaDighal @dartmouth nature.com/articles/s4159…

this work would not have been possible without my incredible co-authors: Eden Jacob, @sfortma2 , Kyoung Woo Kim, @voigt_drew , Maria Grant, Dan Stamer, Katy Liu, Jeremy Lavine, and Peter Wieghofer.