Yash D Shah MD MPH

Our neuro team at Our Lady of the Lake Children’s Health is honored to have played a role in transforming this young girl’s life through innovative care. Grateful for the dedication and collaboration that made this possible. . theadvocate.com/sponsored/bato… via @theadvocatebr @AmEpilepsySoc @AmericaEpilepsy @ololhealth @ololchildrens @PERCepilepsy @ChildNeuroSoc @AANmember

Determining whether epileptic spasms are focal or generalized can be challenging and often requires a multimodal approach, including video-polygraphic recordings, neuroimaging, labs, genetics Learn more about the epileptic spasms diagnostic flowchart at onlinelibrary.wiley.com/doi/10.1002/ep…

@williamwallace @grok please provide pubmed source for this and the source of image from the nature journal

How the brain talks to the immune system This diagram shows the inflammatory reflex - a neural circuit where the brain regulates inflammation through the vagus nerve. It’s how psychological stress, inflammation, and immune activity stay linked. 1️⃣ The signal starts in the brain The vagus nerve carries electrical impulses from the brainstem to the spleen, the body’s blood-filtering and immune-coordinating organ. 🟢 Example: Deep breathing and meditation can activate the vagus nerve, lowering heart rate and reducing circulating inflammatory markers like CRP and IL-6. 2️⃣ The spleen acts as a relay When the vagus nerve is stimulated, it triggers the splenic nerve to release noradrenaline, which activates immune T cells to release acetylcholine. 🟢 Example: In animal models, vagus nerve stimulation increased noradrenaline in the spleen within minutes, showing how fast the nervous system can modulate immunity. 3️⃣ Acetylcholine calms inflammation This neurotransmitter binds to receptors on macrophages, reducing the release of tumor necrosis factor-α (TNF-α), an inflammatory cytokine involved in chronic disease. 🟢 Example: Clinical studies using implanted vagus nerve stimulators in rheumatoid arthritis patients lowered TNF-α levels and improved joint pain without immunosuppressive drugs. The inflammatory reflex shows that inflammation isn’t just chemical, it’s electrical. The brain can literally tell the immune system when to stand down.

@rfeers This is great! What app did you use to create these visuals? Obsidian ?

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Linear Regression clearly explained 👇🏻

Here is link to both the papers - US- pubmed.ncbi.nlm.nih.gov/39854828/ EU- onlinelibrary.wiley.com/doi/10.1002/ep…

What do you think of these two #LGS approaches? Let’s discuss! #EpilepsyTwitter @PERCepilepsy @EpilepsyFdn @AmericaEpilepsy @CureEpilepsy @EpilepsySparks @AmEpilepsySoc @ACNS_org @ChildNeuroSoc @EpilepsyLA @APNIChildNeuro @AocnIndia @flicna @icnapedia @RareEpilepsy @fmolhs @ololchildrens @ololhealth

#LGS #Epilepsy #Neurology #Epileptology 🧠 New insights into Lennox-Gastaut Syndrome (LGS) management! Two recent papers offer contrasting, yet complementary, perspectives from Europe 🇪🇺 & the US 🇺🇸. Let's dive in! 🧵

@autismspeaks @Autism @AutismCapital @DukeAutismCtr @NationalAutism @AutismSociety @Spectrum @masgutovas @AmbitiousAutism

13/ 💬 Your Thoughts? Have you or your patients tried MNRI therapy? I’d love to hear your experiences or thoughts. Let’s discuss! 👇💬

Recently, I met a young patient with autism spectrum disorder (ASD) who showed remarkable progress in feeding and behavior through MNRI therapy. This inspired me to explore this therapeutic approach further. Here’s what I learned! 🌟#autism