Yang Cheng (ChengLab)

Excited to share our new paper in @ImmunityCP! We probed 1169 T cell epitopes, and showed that tumor-resident HBV-specific Trm correlated with relapse-free survival in HCC patients. @EvNewell1 @astar_research @SuPinChoo2 @helloimbavani cell.com/immunity/fullt…

@StJohnLab Congratulations!

Did you know that the fetal immune system can protect from congenital infection before birth? -Proud to share our study identifying protective functions of #microglia, contrasting the harmful early influence of #monocytes and primitive macrophages to #zika virus infection.

@FGinhoux Congrats Kevin!!

So proud of Dr Kevin Mulder! The one and only ! Congratulations Kevin

@FGinhoux A very nice read!

A very nice perspective on MDSCs … still not sure what they are! nature.com/articles/s4157…

Want to analyze Single cell, Multiomics, Spatial or ATAC-seq data but don't know where to start? Or do you face problems in analysis ? Fret not, we have a solution for you. Our lab has developed ezSingleCell - nature.com/articles/s4146…

Great things can happen twice in a week! I'm stoked to share the news that I have been awarded for the NSTC Emerging Young Scholar Fellowship and The Young Scholar Creativity Award! It will allow us to further delve into the function and phenotype of virus-specific Trm cells!

@iannaconelab @CellCellPress Congratulations guys! and one more study showing that there is no real T cell exhaustion in HBV..? 😉

💡Exciting news! Our latest research is now published in @CellCellPress: "Therapeutic potential of co-signaling receptor modulation in hepatitis B" 🚀🧵(1/11) 🔬Using mouse models, we traced the development and fate of dysfunctional CD8+ T cells, showing that hepatocellular priming induces a unique dysfunctional program distinct from classical exhaustion. (2/11) 🌟Key finding: Blocking co-inhibitory receptors like PD-1, CTLA-4, and LAG-3 showed minimal effect. However, activating 4-1BB and OX40 transformed dysfunctional CD8+ T cells into antiviral effectors. (3/11) 📊Prolonged antigenic stimulation leads to a self-renewing, long-lived population of CD8+ T cells with a unique transcriptional profile, including progenitor/stem-like and tissue-resident memory cells. (4/11) 📌In chronic settings, only 4-1BB maintained expression across all dysfunctional subsets, making it a prime candidate for therapeutic intervention in chronic HBV. (5/11) 🧬In HBeAg+ chronic patients, 4-1BB activation showed the highest potential to rejuvenate dysfunctional CD8+ T cells, making it a prime candidate for therapeutic intervention. (6/11) 🔑Our findings suggest that targeting all dysfunctional T cells, rather than only stem-like precursors, holds promise for treating chronic HBV infection. (7/11) 💡Mechanistic insights: 4-1BB activation enhances effector molecule expression and CD8+ T cell cytotoxicity, driving robust antiviral responses. (8/11) 🔍This study provides a comprehensive atlas of the co-signaling receptors induced in dysfunctional HBV-specific CD8+ T cells and reveals potential targets for therapeutic intervention. (9/11) 👏Huge thanks to our incredible team and collaborators, especially @frarro1, @Chiara_Laura91, Micol Ravà, @CaroCKrueger, @FichtMaria, Keigo Kawashima, and @CristianBecc who co-led the study. This work wouldn't be possible without you! (10/11) 📖Dive deeper into our study and its implications for HBV treatment. We're excited to hear your thoughts and engage in discussions! Full paper here: authors.elsevier.com/sd/article/S00… 💬📚 (11/11) @SanRaffaeleMI @MyUniSR @ERC_Research @AIRC_it @EMBO_YIP @ArmeniseHarvard

It was amazing to meet up with old and new friends at @EASLnews. Had great food and science discussion. Special shout out to Tobias Boettler @teximmed2, who I haven't seen in 13 years after San Diego! @Anto_Berto @ljpally19 @druppygill @bert_le @VenzinValentina @CristianBecc

@asharmaiisc @nhmrc Congrats Ankur! Also some familiar faces in this great team!

Very excited to co-lead @NHMRC 2023 Clinical Trial & Cohort Grant (6M AUD) with Jacob George for the clinical trial (DEFINERx050) and cohort (PRECISION). We will establish a pan-national HCC cohort across 5 states & 13 clinical sites to evaluate #oncofetal score and other biomarkers of IO response in #LiverCancer

Next Early Career Immunology seminar is Jun Wang @nyuniversity May 14, EST 12pm Zoom temple.zoom.us/webinar/regist…

Next ECI talk with be featured @alpcorreia on March 26th, GMT 9AM/CET 10AM! She will share her work on immune regulation of dormancy! Please register to receive the Zoom link!

@maini_lab @Leo1401j @iit_ucl Many congratulations @Leo1401j !!!🍻🍻🍻

Massive congratulations to @Leo1401j for his Wellcome Career Development Award...a whole EIGHT years of funding to expand his fantastic research group @iit_ucl 🤩👏🍾🥂🍾

Next Early Career Immunology ECI seminar is Ankur Sharma @asharmaiisc @PerkinsComms Feb 20, 3pm Singapore/Beijing/HK time Oncofetal ecosystem oncofetal.com Zoom registration uci.zoom.us/webinar/regist…

Our paper led by Heeju Ryu (now Asst Prof at SKKU Korea) and with @PaulNghiem @UW Steve Fling CITN @fredhutch is out at @CellRepMed. We’re excited about insights gained from the phenotypic profiling of circulating MCPyV-specific cells in this study. doi.org/10.1016/j.xcrm…

Excited to share our new paper @ScienceMagazine All credit goes to my (ex)team members @im_mel_nology @ImmanuelKwok #LeonardTan #Changming. Special thanks to @AndrsHidalgo16, @FGinhoux and @OstuniLab for their continuing support and friendship

@lai9uan @ScienceMagazine @im_mel_nology @ImmanuelKwok @AndrsHidalgo16 @FGinhoux @OstuniLab Congrats man! When can we grab a drink again?

@maini_lab @pallett_lab Prosecco has been the proven facilitator for human reproduction 🤣

@Youngthepro @pallett_lab but the Prosecco bottles you so kindly sent me still went round everyone -thanks again Yang 😀

From all of us, to all of you… 🎄 MERRY CHRISTMAS 🎄

Next Early Career Immunology webinar Nov 14, 12pm EST @RamosNalio en.idor.org/post_scientist…

@FGinhoux @Nature Congrats man!! and Dong!

Excited and relieved to share with you our microglia-sufficient brain organoid work just online @Nature nature.com/articles/s4158… IPSC-derived microglia reprogram them metabolically! And make them mature faster!

Coming join us for today's talk by @HarikeshWong from @MIT @ragoninstitute !