algobaker

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algobaker

algobaker

@algobaker

ML PhD student Previous: research at LLM hyperscaler, AI in pharma.

Cyberspace Katılım Nisan 2021
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algobaker
algobaker@algobaker·
A year here and he still dreamed of cyberspace, hope fading nightly. All the speed he took, all the turns he'd taken and the corners he cut in Night City, and he'd still see the matrix in his dreams, bright lattices of logic unfolding across that colourless void... The Sprawl was a long, strange way home now over the Pacific, and he was no Console Man, no cyberspace cowboy. Just another hustler, trying to make it through. But the dreams came on in the Japanese night like livewire voodoo, and he'd cry for it, cry in his sleep, and wake alone in the dark, curled in his capsule in some coffin hotel, hands clawed into the bedslab, temper foam bunched between his fingers, trying to reach the console that wasn't there.
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Mark™
Mark™@thinkwithmark·
We raised $1M dollars to reinvent how people read. Introducing Mark II - a $159 AI bookmark. Thread below
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algobaker
algobaker@algobaker·
@max_spero_ Because most people that would buy this over regular meat don't have any interest in eating food that got murdered
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Max Spero
Max Spero@max_spero_·
Can anyone explain to me why we don’t have ethical meat? Surely we can give the farm animal a significantly better life than it would have lived in the wild.
Max Spero tweet media
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Lon()
Lon()@Lon·
@thecowmilk @MartinShkreli You're right. Nobody has to do anything. You don't even have to get out of bed in the morning if you don't want to...
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Martin Shkreli
Martin Shkreli@MartinShkreli·
when i was younger, i was very insecure. i did this kind of thing too. over time you learn that it is critical to be truthful and not misleading about every single thing you do. i had to learn this lesson the hard way, but boy, have i internalized it. UNDERSELL yourself.
Martin Shkreli tweet media
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Natasha Malpani 👁
Natasha Malpani 👁@natashamalpani·
isomorphic labs just raised $2.1 billion. no human patient has been dosed yet. the first clinical trials are expected end of 2026. zasocitinib just cleared Phase 3. the first AI-designed drug to do it. zasocitinib was discovered by nimbus therapeutics using @schrodinger's physics-based simulation platform. the model understood molecular interactions from first principles. it validates one specific thesis: AI works in biology when the search space is large, the functional assay is clear, and you can close the loop between model and experiment. @IsomorphicLabs’ bet is that this same first-principles approach scales across the entire drug discovery stack. multiple therapeutic areas. multiple modalities. from structure prediction all the way to the clinic. zasocitinib is the closest validation point this thesis has ever had. it is also a reminder that one layer working does not mean the whole stack works. the 90% Phase 2/3 failure rate has not moved. the virtual cell is unproven. the hardest layers are still ahead. biology does not digitise uniformly. zasocitinib is the first proof. isomorphic is the next wager.
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Annihilation
Annihilation@Fivefour3two1·
Do you prefer to read .pdfs on...
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algobaker
algobaker@algobaker·
@illyism Met incredibly few locals in Switzerland that actually thought working at Google was cool. Not sure who you're hanging around with
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ILIAS ISM
ILIAS ISM@illyism·
I lived in Dubai for a year and Switzerland for 3 years, both insanely expensive and neither produces real founders Dubai's status game is yachts and Lambos, so even ambitious people end up doing crypto rugs and dropshipping courses and larping on instagram Switzerland's status game is respectable employment at UBS or Google, so smart people optimize for corporate promotions and not products (you need $25k to even incorporate), the goal is to make enough to never have to risk anything again + without a proof of salary you can not even rent Bali and Thailand are kinda opposite, cheap, but the status game is lifestyle and freedommaxxing ("I work 4 hours from a beach") I think SF respects shipping, NYC respects exits, China respects winning, and everything is built around that
@levelsio@levelsio

The only 2 places where I felt ambition like this are the US and China Nomad hubs like Bali and Thailand are nice but often people there get stuck coasting at $5K MRR because it's just cheaper to live there, so that puts kind of a natural limit on ambition, very quickly you already make "enough" SF/NYC are so ridiculously expensive to live, so you HAVE to make a lot of money, and the high cost of living is a natural filter that keeps only broke but super ambitious or already successful people (and of course nepo babies esp NYC) China is not so much expensive to live, but there's some natural cultural ambition to become #1 in everything that's very infectious

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Psyho
Psyho@FakePsyho·
@colossusmag While Scott is great, calling him "the greatest competitive programmer the US has ever produced" is unfair to other great people. AFAIK, neither Dario or Alexandr competed "for their countries on international math and science teams". So that part is also incorrect.
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Colossus
Colossus@colossusmag·
Scott Wu is the co-founder of Cognition AI, one of the fastest-growing companies in history. He’s also the greatest competitive programmer the US has ever produced. You may have seen him doing impossible card tricks and mental math. You’ve never seen him asked about weed, Michael Jordan, cancer, and human consciousness over a punnet of strawberries. That is what Colossus editor-in-chief Jeremy Stern did on a recent visit to San Francisco. For those less familiar with @ScottWu46: In 2nd grade, he entered a math competition for 7th graders, lost, and was so furious he still fumes about it 20 years later. The next year he entered the 9th-grade division as a 3rd-grader and got a perfect score. Then he won first place at the US national middle-school math competition and three straight gold medals at the International Olympiad in Informatics, where he became the greatest American gold-medalist and coach in history. Most of the people running the biggest AI companies met as teenagers, competing for their countries on international math and science teams. OpenAI’s Greg Brockman, Anthropic’s Dario Amodei, Meta’s Alexandr Wang, to name just a few. Most agree that the von Neumann among them was Scott Wu. In November 2023, a few weeks after his mother died of lung cancer, on the day Sam Altman was fired from OpenAI, Wu founded his own AI company: Cognition. He was 26 and saw earlier than almost anyone that AI would converge on agents that work in the background, 24/7, like coworkers. He shipped Cognition’s AI software engineer Devin in March 2024. It worked poorly, and he took intense public criticism for it. Now, in its first 18 months of service, Devin has generated $445 million of revenue run rate and usage has doubled every eight weeks. The US Army, Goldman Sachs, and Mercedes-Benz are all customers. Cognition is raising at a valuation around $25 billion. @JeremySternLA sat down with Wu, the emperor of the nerds, to ask the questions we’d all ask one of the smartest people in America—building the most consequential technology of our generation—if we ever got the chance. As well as MJ and weed, they talk about the cluster of competitive math prodigies behind so much of AI, what makes us human when AGI arrives, and why Wu believes he was put on this earth to teach AI how to code. Read the piece below.
Colossus tweet media
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Jake Wintermute 🧬/acc
When I meet a biotech founder the more intensely secretive they are about their new idea the more likely that idea turns out to be "use AI to cure aging somehow"
Jake Wintermute 🧬/acc tweet media
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Erika Alden DeBenedictis
Erika Alden DeBenedictis@erika_alden_d·
I think the first successful virtual cells are going to model prokaryotes, not eukaryotes. It’s technologies like BioBloom that are going to be the difference between being able to collect enough data and NOT. Thoughts? @ChanZuckerberg @DBBurkhardt @arcinstitute @joncalles
PioneerLabs@Pioneer__Labs

This tube is a library of bacteria with every single-base-pair genome mutation, all DNA-barcoded.🧪Growth + barcode sequencing = data on millions of mutations. 📄 Report: biorxiv.org/content/10.648… Retweet if you want more data, and read on if you want to use the library! 🧵

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algobaker
algobaker@algobaker·
@koeng101 Been on the market for a while already no?
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algobaker
algobaker@algobaker·
@DdelAlamo 'and post a firehose of AI-generated posts' why would anything someone is posting on linkedin affect a decision of whether to pursue hiring them
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Diego del Alamo
Diego del Alamo@DdelAlamo·
LinkedIn as an employer looking for candidates is like ipTM: great for filtering candidates discovered elsewhere, but absolute dogshit for discovery. Quite a few people find ways to fluff up mostly-empty CVs and post a firehose of AI-generated posts. Anyway, role still open
Diego del Alamo@DdelAlamo

Takeda Pharma is hiring scientists at both the straight-out-of-PhD and senior levels in the AIML group, particularly those with experience training, modifying, and applying foundation models. Please reach out if youre interested and want to make the jump to industry, link below👇

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algobaker
algobaker@algobaker·
@stevenyfeng Would imagine "people who tried to write a paper in 3 days for social media clout" barely moves the numbers on total submission numbers. The negative reactions to this are just pearl clutching
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Paul T Kim
Paul T Kim@paultkim_ipd·
Our preprint for de novo DNA binder design is out! biorxiv.org/content/10.648…. The punchline: methods have gotten good enough that we can find sequence specific DNA binding proteins from screening as few as 96 designs per target.
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zeta
zeta@zeta_globin·
how it feels to work on small molecule drugs after years in cell therapy
zeta tweet media
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algobaker
algobaker@algobaker·
@SimonDBarnett There's a lot of value in just having another smart ride-or-die partner that is working on something with you. That has nothing to do with raw productivity but will still be a big reason we don't get loads of these
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algobaker
algobaker@algobaker·
@shae_mcl Is it because the genome doesn't carry the information content or that we don't have the tools to map it to something useful for an individual
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algobaker
algobaker@algobaker·
@pfau This isn't the kind of logic that you use to come up with new algorithmic ideas? I'm always thinking about conspiracies
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David Pfau
David Pfau@pfau·
I sometimes forget how weird the dropout paper is.
David Pfau tweet media
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