Wilfred Relmar

Bioglutide (NA-931) doesn't exist, and the CEO is coming after me with defamation takedown requests as well as cease and desists. Lloyd Tran is a complete fraud, and I'm hosting this video here in case my version on YouTube is deleted. Investors are being swindled by this con artist and I want as many people to know as possible. Whenever anyone mentions Bioglutide, Biomed Industries or Lloyd Tran, every reply should be "scam", "fraud" and "liar".

@designmom @FemCondition You said: "Men don’t. Ever.". This is false. Just admit that the words you used were incorrect.

Hey men, if having a genetic legacy is important to you, I have some bad news: Men don’t. Ever. Only women do. Literally.

@4nt1p4tt3rn Mystical secrecy on X is always pure bullshit.

You have no idea the type of intel you can develop running a single TOR exit node, let alone a large number of them.

@mvalsmith @4nt1p4tt3rn Explain mechanistically what "downgrade encryption" means to you in the context of being a TOR exit node.

@4nt1p4tt3rn I knew one guy who at one point ran 40% of the tor exit nodes. He would downgrade encryption, inject malware / exploits, collect data and files. No one should use Tor for anything other than trying to hide themselves from the endpoint, and even that is iffy.

@stikves @Hitchslap1 My favorite retorts to the CICO model of obesity are the ones where they just decide they'll change the CO part and say "See? It can happen!".

@Hitchslap1 There are two mechanisms... One is, yes, people calculate wrong, and they aren't actually deficient The second one is more insidious. The body will "adopt" the base metabolic rate to continue storing fat. Once your hormones are broken it becomes a vicious cycle.

I’ve often wondered about this. How is it possible to be in a caloric deficit and not lose weight?

What mental calculation are you doing when you convince yourself that "the risk of harm is too high", given you know how deadly and awful obesity is as a disease, and how many QALYs grey market users are getting from its use? To me, positions such as this demonstrate such a profound lack of understanding re: cost/benefit analysis and omission bias. We have hundreds of thousands, if not millions of people taking bootleg GLP-1 RAs from China globally: that's a LOT of fat getting busted. Where exactly is the risk of harm? How many overdoses have we seen? How many disfigurements or deaths? I think either one of two things is true: your risk calculus of grey market is completely off and ignores real-world observations or you severely underestimate just how problematic obesity is as an illness. You can say it's a brand risk and that's okay, but don't delude yourself - or try to convince others - that the risk profile is too great. This is completely contrary to the facts.

Appreciate the s/o, and I also appreciate that you seem to be a super reasonable guy. (Even though I think you were pretty hard on me at one point) I haven’t promoted RUO, not because I disagree with your points, but because the risk of harm is too high for me to feel comfortable pointing people in that direction. That said, I acknowledge that there are scores of people in my own community that have been pushed that way, and whom have benefitted greatly from RUO in peptides. I even highlighted one of their stories recently. Their stories matter just as much as someone who has cheap access to branded meds.

Too Long... dont read. People should be using legitimate sources of GLP1s, but the misinformation from people with big platforms is frustrating. Some facts: Overseas direct from China are 99% what they say they are. The amount of testing that goes on in these groups dwarfs what your typical compounding pharmacy goes through. Any vendor that has bad product would simply be shunned. The gray market rumor mill runs fast and deep. Note: It used to be a lot worse, but @finnrick_tests really has changed the market for the better. The majority of peptides from China are made in exactly the same factories that compounding pharmacies get their products from (and is many cases the same as that provide to big pharma). You pay extra for the paperwork trail. It's not hard to get hold of the greenlit list for APIs. Ozempic is not even in the same category as Retatrutide... saying its an effective substitute is crazy. I understand that fearmongering gets more clicks than not, but integrity and honest matter. The correct argument is that the province of gray market peptides untraceable and that people that use them are taking a risk. It also cuts into the profit of pharma companies profits which could disincentive investment in future drugs. But having been in that world for a while and participating in many groups, forums, its extremely rare for people to experience negative reactions, and its almost always due to mis-dosing. Additionally, they work... they work well. To get rid of the gray market, two things have to happen: 1. The price of Tirzepatide and Retatrutide needs to come down significantly. (NO ONE WANTS Ozempic). To completely kill the Overseas Gray Market, the prices would need to be about $50 to $100 a month. $100 / $200 a month would make a sizeable dent however. Current Gray Market Prices are about half of the numbers I stated before. 2. The second big thing that needs to happen is easing up on access to GLP1s. MDs are quite conservative about prescribing, and this drives people to the gray market. Telehealth companies do solve this to some degree. I find myself admiring @ManOnThePen more an more these days. I do admire his commitment to working in the system, but the fact remains that obesity is a lot bigger issue among those on the lower and working class rungs of society, and the prices that are being touted in the media... the new "lower" prices are still out of reach of a very large segment of the population. Final point... the current peptide discourse to me is so weird when you consider the same people that appear to be so anti-peptide never mention alcohol or tobacco or marijuana. All of these substances... legally... are way risker and more dangerous than peptides. Once again... people should be getting their GLP1s from legitimate sources... and they should be able to afford them.

I have a very close friend with a low bodyfat percentage who historically engaged in many disordered habits that made her life miserable. Binge eating followed by purges, punishing fasts, multi-hour walks - very ugly stuff to achieve the body she desired. She started to self-administer low doses of retatrutide and the changes were fast and significant. Incidents of disordered eating essentially disappeared, her mind became way more peaceful, she stopped doing all of the bad things to get the result. We certainly don't have the data yet, but I'd wager most people's gut reaction to GLP-1 RA usage among those at the opposite end of the eating disorder spectrum (i.e. skinny instead of obese) is likely overreactive and lacks the nuance it deserves. Will any institution muster up the courage to run a trial on this topic? I really hope so - if it could ever get past an ethics board, which would be a very tall order. I don't think it's as cut and dry as "this doctor is awful".

the doctor who prescribed a GLP-1 to a 5’10” woman who weighs 99 pounds needs to lose their fucking license holy shit #SLOMW

@securezer0 @GaetenD There's no "house" here, though. Polymarket is agnostic to outcomes and is never the counterparty.

@GaetenD The house always wins

A lot of people are upset about Polymarket trying to become a financially sustainable company.

@MartinShkreli @orphcorp "Sure, my contrarian takes against bootleg GLP-1 RAs has insane omission bias and I've failed to do the world's easiest cost-benefit analysis, but so what? Only tens of thousands of people would die premature, preventable deaths if the world ran my way!"

@orphcorp correct

@Grooovotron @ck_gen @EconTalker @HeerJeet Again: that's fine, but it's a goalpost shift. The initial claim was that Israel has a "free press" and as an extension of that, free speech. The new claim you're making is that Israel is less restrictive than Iran and Lebanon. I agree with that claim.

@alphaenu @ck_gen @EconTalker @HeerJeet Both of Israel's current enemies execute people for criticizing the government. If you can't tell the difference between that and a nation with a wartime restriction on speech that's totally justified, that's on you.

Zionism is increasingly incompatible with free speech (because it has no defence against reasonable criticism) so we're seeing a new push for censorship in Israel and allied countries.

@Grooovotron @ck_gen @EconTalker @HeerJeet That's fine, but it's a goalpost shift. Israel is no longer a country with a "free press" or free speech if sharing strike footage is illegal. You might think the censorship is worth it and that's okay, but so does every country with restrictions on the media.

@ck_gen @EconTalker @HeerJeet because it provides Iran with missile targeting data google is free Louis

I don't have the data at hand, but I'm almost certain there's no dose of semaglutide that matches retatrutide's weight loss and that has fewer side effects. Tirzepatide was a big step up in this regard. High dose semaglutide (which you need to even get close to tirz/reta) has a LOT of side effects. Check max dose sema data vs 4 mg reta data, for example.

@tbpn @MartinShkreli Reta's problem is that even though it has a higher weight loss %, the % of PTs who have vomiting, nausea, and diarrhea is higher than Zepbound/Ozempic. Is it a superior drug or are the side effects inflating the weight loss number? Plus rapid weight loss = more excess skin

.@MartinShkreli says taking retatrutide is the "worst risk-reward decision you could possibly make": "The people that are taking peptides, and have these 'peptide stacks,' are mostly people in SF, maybe in NY. They're very wealthy people. They don't know what the rest of the world looks like." "Nobody else in Middle America is excited to do this. It's not normal to inject yourself with things. This isn't a thing everyone should be doing." "What is your upside to taking illegally manufactured retatrutide — you can't verify it, etc. — versus just taking Ozempic?"

There's a world of difference between self-medicating with a drug that will increase your lifespan and general health once a week and taking a drug like heroin or fent that will kill you decades earlier than you ought to have died. These two things are not the same: you should be able to separate the act of injecting revolutionary medicine and the act of injecting awful poison into your body.

He’s not wrong. Asia and the Middle East avoid anything that even resembles drug culture, and they see plenty of news with our people in the streets or LA and SF with needles sticking out of their arms like zombies. It works in big US cities bc people are desensitised to drug culture, stepping over bodies on the way to work.

@czapa1234 @whyfcfc @tbpn @MartinShkreli If you interpret "can't verify what you're taking" as "this isn't FDA approved yet" instead of "the origin source and API aren't rigorous", you're not a serious person capable of serious discussions about this topic, and you should probably just do something else with your time.

@whyfcfc @tbpn @MartinShkreli Lab testing is not the same as FDA drug approval, look up the difference. Hope it clears some thing up 😆

"Just take Ozempic instead" Increasingly common Shkreli L to try and stay relevant in the pharma X space. Semaglutide is good, but the fact he mentions it here instead of tirzepatide as the counterfactual shows how ill-informed he is. Tirzepatide is just objectively better: fewer side effects, more weight loss. I actually do not know of any metric, aside from potentially price (which is debatable re: downstream effects/food budget anyway), where semaglutide would be what I'd recommend. If you're pitching sema instead of tirz as an alternative to reta, NGMI. He should avoid talking about this topic until he actually understands it.

@realjarah @tbpn @MartinShkreli Eli Lilly have demonstrated safety and efficacy with retatrutide. There are now multiple phase 2/3 trials confirming this. Just because the FDA hasn't rubber stamped it yet doesn't mean you throw the baby out with the bacteriostatic water.

@tbpn @MartinShkreli Gotta say I'm with Martin on this There's a reason Lilly/Other big Pharma have to spend hundreds of millions on drug trials The incentives for proving safety/efficacy are decades of patent protection and lots of $ weirdly enough its one of capitalisms most virtuous mechanisms

I'm currently at a healthy BMI thanks to reta. If I go to a doctor here in Australia and say "Hey, I want tirzepatide to maintain", they won't give it to me, because my BMI is healthy - I do not qualify. Do you have any other solution other than "okay, hop off reta, put 30 kilos of body fat back on, develop pre-diabetes, then head back to the GP"? "Just get a prescription" ignores so many material factors. It's like you've never interacted with the medical system from the patient perspective before. The amount of hoop jumping they make you undertake is ridiculous.

@somewheresy why compound anything? just get an rx lol

there's a big difference when speaking about "peptides" (GLP-1s you compound yourself) or "peptides" (all the other stuff that exists on a spectrum of snake oil to cancer juice to completely effective)

Training at the gym is locally enjoyable. Ask anyone after they've finished training: "do you regret doing that? How do you feel?" - almost everyone will say "I don't regret it, I feel really good!" Abstaining from food SUCKS. It's not enjoyable. There's ZERO payoff. It's mental torture 24/7, and your brain rebels against the activity, because it has no mechanism for directly punishing excessive caloric consumption. It hasn't needed to for 200,000~ (and long before that).

Ngl it's pretty funny that someone can have enough discipline to liftmaxx but not to cut calories below replacement for a month

@84_wintermute @homegymcoop @CoachDanGo Magnus' muscle mass to bodyweight ratio would be in the top 99.9% of all humans, if not higher.

@homegymcoop @CoachDanGo almost like bigger muscle volume doesn't automatically equal more strength

Reminds me of the video where a climber who was 2x smaller than Larry Wheels was easily back rowing the same weight. Functional strength is a real thing.

@garrison_james @CoachDanGo The "bulk" guy has multiple world records, including a 648 pound bench press at 308. He's quite literally one of the strongest humans to ever exist.

@CoachDanGo Strength and bulk are not always the same thing.

@DanielB02277937 @CoachDanGo Completely incorrect. Nothing correlates more to strength than muscle mass.

@CoachDanGo The muscle mass is largely irrelevant to actual strength. Maybe even detrimental i.e. material fatigue, gravity/mass drain, nutrition demands.