Anand Mayakonda 🕉️

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Anand Mayakonda 🕉️

Anand Mayakonda 🕉️

@anand_mt

Bioinformatics, genetics, and cancer genomics @dkfz. I also tweet #Rstats #dataviz @baseRgraphics creator @grabstractio

Heidelberg Katılım Nisan 2009
291 Takip Edilen276 Takipçiler
Lior Pachter
Lior Pachter@lpachter·
Bionmi is amazing but from what I can tell it facilitates *running* complex data analysis with ease, which is a very different thing from *doing* analysis, whether poorly or well, with difficulty or with ease.
Anand Mayakonda 🕉️@anand_mt

@KexinHuang5 We are using this already in the lab and it’s extremely useful. Especially for our colleagues with no bioinformatic skills, they’re able to do complex data analysis with ease. Would be happy to test it to the limits.

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Anand Mayakonda 🕉️
@marcora @lpachter Maybe controversial take, but lots of data oriented research is done this way. “Let’s do single cell seq or stomic and see what comes out” and, most of the times it does works out. It’s a bottom up approach, not saying it’s the best way but it’s one of the way.
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Edoardo Marcora
Edoardo Marcora@marcora·
@lpachter The prompt in the bionmi promotional video says "analyze these data and generate hypotheses". How can scientific analysis be done without a purpose/research question, let alone expertise in bioinformatics? Else, how would you judge the quality of the results and explain them?
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Anand Mayakonda 🕉️
@lpachter Fair enough. For someone who hasn’t used anything other than windows explorer - using biomni to go from a hypothesis to data extraction from pubmed/geo, performing DGE, cross checking with depmap and tcga, summarizing them into plots is already impressive.
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Anand Mayakonda 🕉️
@KexinHuang5 We are using this already in the lab and it’s extremely useful. Especially for our colleagues with no bioinformatic skills, they’re able to do complex data analysis with ease. Would be happy to test it to the limits.
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Anand Mayakonda 🕉️
Anand Mayakonda 🕉️@anand_mt·
@antonosika I wish they would have made it public once it’s been formally approved. It’s just a proposal for now.
Anand Mayakonda 🕉️ tweet media
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Anton Osika – eu/acc
Anton Osika – eu/acc@antonosika·
Today, the EU published the formal bill for EU Inc, a new legal framework that will make building companies across Europe a lot easier. I've seen firsthand how fragmented rules can hold back European talent. EU Inc addresses this directly with 48-hour online registration, zero minimum capital, and standardized stock options, making it simpler to get started and grow. When I started Lovable, my goal was to empower anyone with an idea to build. This new regulation aligns perfectly with that vision because it helps remove the hurdles and accelerate the journey for builders throughout Europe. It really opens up the opportunity to create a global company from anywhere in Europe. I'm incredibly optimistic about what this means for founders.
Ursula von der Leyen@vonderleyen

With EU Inc., we are making it drastically easier to start and grow a business all across Europe ↓ twitter.com/i/broadcasts/1…

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Anand Mayakonda 🕉️
Anand Mayakonda 🕉️@anand_mt·
When they say SaaS is dead - this is what it means. It’s faster to build one than to search for one.
Andrej Karpathy@karpathy

Very interested in what the coming era of highly bespoke software might look like. Example from this morning - I've become a bit loosy goosy with my cardio recently so I decided to do a more srs, regimented experiment to try to lower my Resting Heart Rate from 50 -> 45, over experiment duration of 8 weeks. The primary way to do this is to aspire to a certain sum total minute goals in Zone 2 cardio and 1 HIIT/week. 1 hour later I vibe coded this super custom dashboard for this very specific experiment that shows me how I'm tracking. Claude had to reverse engineer the Woodway treadmill cloud API to pull raw data, process, filter, debug it and create a web UI frontend to track the experiment. It wasn't a fully smooth experience and I had to notice and ask to fix bugs e.g. it screwed up metric vs. imperial system units and it screwed up on the calendar matching up days to dates etc. But I still feel like the overall direction is clear: 1) There will never be (and shouldn't be) a specific app on the app store for this kind of thing. I shouldn't have to look for, download and use some kind of a "Cardio experiment tracker", when this thing is ~300 lines of code that an LLM agent will give you in seconds. The idea of an "app store" of a long tail of discrete set of apps you choose from feels somehow wrong and outdated when LLM agents can improvise the app on the spot and just for you. 2) Second, the industry has to reconfigure into a set of services of sensors and actuators with agent native ergonomics. My Woodway treadmill is a sensor - it turns physical state into digital knowledge. It shouldn't maintain some human-readable frontend and my LLM agent shouldn't have to reverse engineer it, it should be an API/CLI easily usable by my agent. I'm a little bit disappointed (and my timelines are correspondingly slower) with how slowly this progression is happening in the industry overall. 99% of products/services still don't have an AI-native CLI yet. 99% of products/services maintain .html/.css docs like I won't immediately look for how to copy paste the whole thing to my agent to get something done. They give you a list of instructions on a webpage to open this or that url and click here or there to do a thing. In 2026. What am I a computer? You do it. Or have my agent do it. So anyway today I am impressed that this random thing took 1 hour (it would have been ~10 hours 2 years ago). But what excites me more is thinking through how this really should have been 1 minute tops. What has to be in place so that it would be 1 minute? So that I could simply say "Hi can you help me track my cardio over the next 8 weeks", and after a very brief Q&A the app would be up. The AI would already have a lot personal context, it would gather the extra needed data, it would reference and search related skill libraries, and maintain all my little apps/automations. TLDR the "app store" of a set of discrete apps that you choose from is an increasingly outdated concept all by itself. The future are services of AI-native sensors & actuators orchestrated via LLM glue into highly custom, ephemeral apps. It's just not here yet.

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Kexin Huang
Kexin Huang@KexinHuang5·
Today we’re launching Phylo, a research lab studying agentic biology, backed by a $13.5M seed round co-led by @a16z and @MenloVentures / Anthology Fund @AnthropicAI. We’re also introducing a research preview of Biomni Lab, the first Integrated Biology Environment (IBE), where we’re imagining a new way biologists work. Biomni Lab uses agents to orchestrate hundreds of biological databases, software tools, molecular AI models, expert workflows, and even external research services in one workspace, supporting research end-to-end from question to experiment to result. Agents handle the mechanics, while you define the question, then review, steer, and decide. Scientists end up spending more time on science: asking questions, understanding mechanisms, and eliminating diseases. Phylo (@phylo_bio) is a spin-out of @ProjectBiomni, where we will maintain the open-source community and push open-science research. I’m grateful to continue building with my co-founders @YuanhaoQ @jure @lecong and the dream founding team @serena2z @TianweiShe @huangzixin20151 @gm2123 @margaretwhua @malayhgandhi. We’re also fortunate to be advised by leading scientists @zhangf, Carolyn Bertozzi, and @fabian_theis, and supported by an amazing group of investors including @JorgeCondeBio @zakdoric Matt Kraning @ZettaVentures @dreidco @conviction @saranormous @svangel @valkyrie_vc and others. Biomni Lab is available for free today: biomni.phylo.bio Learn more in our launch post: phylo.bio/blog/company-f… We are also hosting launch events - join us at South San Francisco: luma.com/n8k8qb0n Virtual: luma.com/l5ryjaij We’re also hiring! phylo.bio/careers
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Anand Mayakonda 🕉️
Anand Mayakonda 🕉️@anand_mt·
I wonder the status of bioinformatic toolsmithing in 2026. The technical barrier is now minimal with coding agents (Claude code for ex.). Anyone with a problem and curiosity can now ship. This is transformative but the question is will journals restrict tools built with AI?
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Anand Mayakonda 🕉️
Anand Mayakonda 🕉️@anand_mt·
@AnthropicAI really cooked with opus 4-5. Amazing how Claude code rips through complex comp bio tasks with planning and execution 🙌 CC especially excels at instruction following where other coding agents struggle.
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Anand Mayakonda 🕉️ retweetledi
Science Magazine
Science Magazine@ScienceMagazine·
This splash-resistant cup borrows properties from nature to minimize spilling and sloshing. Learn more in @ScienceAdvances: scim.ag/49g8oFq
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grabstract
grabstract@grabstractio·
#grabstract can now add citations to your manuscript. Just paste your text; AI finds relevant PubMed citations and formats them to 100+ journal styles. It's like EndNote or Zotero on autopilot. Try it for free at grabstract.io
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Anand Mayakonda 🕉️ retweetledi
Cancer Cell
Cancer Cell@Cancer_Cell·
Online Now: Advancing CNS tumor diagnostics with expanded DNA methylation-based classification dlvr.it/TPfTYR
Cancer Cell tweet media
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Lior Pachter
Lior Pachter@lpachter·
Academic flexes that I dislike: 1/🧵
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Faheem Ullah
Faheem Ullah@Faheem_uh·
How to convert research paper to slides in 1 minute? First, very quickly, why do we need to do this? ➝ We often need to convert papers to slides ➝ To present the paper in a conference ➝ To present our research to our supervisors ➝ To pitch our research for funding, and so on Creating slides manually takes a lot of time. Now, you can create slides in under a minute. How? You can do this with @grabstractio It is a tool that converts research into visuals. 𝐇𝐨𝐰 𝐆𝐫𝐚𝐛𝐬𝐭𝐫𝐚𝐜𝐭 𝐰𝐨𝐫𝐤𝐬? 1. Go to grabstract.io and log in. 2. Upload your paper and click on Analyze PDF. 3. Now you’ll see the following for your paper ↳ Metadata of your paper ↳ Structure of your paper ↳ PDF Mindmap of your paper 4. Further, you will see the following options ↳ Summary ↳ Journal Club ↳ PDF Poster ↳ Billboard ↳ Podcast ↳ PDF Chat ↳ Manuspect 5. To create slides, click on Billboard, & click Generate 6. It will create one visual with various slides in it. 7. You can copy and paste these as a separate slides 𝐖𝐡𝐚𝐭 𝐈 𝐥𝐢𝐤𝐞𝐝 𝐚𝐛𝐨𝐮𝐭 𝐢𝐭? ➝ I think the information on slides is very relevant. ➝ It only picks the most important information ➝ The slides are perfect for presenting your paper 𝐎𝐧𝐞 𝐭𝐡𝐢𝐧𝐠 𝐭𝐡𝐚𝐭 𝐜𝐚𝐧 𝐛𝐞 𝐢𝐦𝐩𝐫𝐨𝐯𝐞𝐝 ➝The slides are not editable ➝ A researcher should be able to edit these slides Try Grabstract here: grabstract.io It’s very powerful tool for visualizing your research Anything you'd like to add?
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